Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Rosanna De Cicco"'
1
A new synthetic spiroketal: Studies on antitumor activity on murine melanoma model in vivo and mechanism of action in vitro
Autor: Pietro Spanu, Adriano Barra, Alberto Mannu, Rosanna De Cicco, Veronica Trotta, Franco Morelli, Maria Pia Fuggetta, Francesco Deligia, Enrica Zona, Fausta Ulgheri, Paola Carta
Publikováno v: Anti-cancer agents in medicinal chemistry (Online) 19 (2019): 567–578. doi:10.2174/1871520619666190131141400
info:cnr-pdr/source/autori:Fuggetta M.P.; Spanu P.; Ulgheri F.; Deligia F.; Carta P.; Mannu A.; Trotta V.; Cicco R.D.; Barra A.; Zona E.; Morelli F./titolo:A new synthetic spiroketal: Studies on antitumor activity on murine melanoma model in vivo and mechanism of action in vitro/doi:10.2174%2F1871520619666190131141400/rivista:Anti-cancer agents in medicinal chemistry (Online)/anno:2019/pagina_da:567/pagina_a:578/intervallo_pagine:567–578/volume:19
Background:In a previous study, we synthesised a new spiroketal derivative, inspired to natural products, that has shown high antiproliferative activity, potent telomerase inhibition and proapoptotic activity on several human cell lines.Objective:Thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df8f163ad0eca28530ea99bb4df5ab1
http://hdl.handle.net/2318/1735702
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3
A New synthetic spiroketal: Antitumor Activity On Murine Melanoma Model In Vivo and MOA In Vitro
Autor: Pietro Spanu, Maria Pia Fuggetta, Fausta Ulgheri, Francesco Deligia, Giovanni Loriga, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, Franco Morelli
Publikováno v: 4th International Electronic Conference on Medicinal Chemistry, 1-30 Novembre 2018
info:cnr-pdr/source/autori:Pietro Spanu, Maria Pia Fuggetta, Fausta Ulgheri, Francesco Deligia, Giovanni Loriga, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, Franco Morelli/congresso_nome:4th International Electronic Conference on Medicinal Chemistry/congresso_luogo:/congresso_data:1-30 Novembre 2018/anno:2018/pagina_da:/pagina_a:/intervallo_pagine
The natural-like spiroketal, 2-hydroxy-8-methyl-1,7-dioxaspiro[5.5]undec-3-en-5-one (1) has been synthesised and has shown a potent antitumor activity against human tumor cells of different nature and histotype. We have now performed studies for veri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::04e67627b9224c2a6a5f43d781fc36a9
http://www.cnr.it/prodotto/i/395920
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4
Simvastatin inhibits the expression of stemness-related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton
Autor: Rosanna De Cicco, Rosa Carnuccio, Salvatore Baiano, Enrica Zona, Rosarita Tatè, Alessandro Morelli, Veronica Trotta, Maria Urciuoli, Franco Morelli, Maria Pia Fuggetta
Publikováno v: International journal of oncology 51 (2017): 1851–1859. doi:10.3892/ijo.2017.4158
info:cnr-pdr/source/autori:Tatè R, Zona E, De Cicco R, Trotta V, Urciuoli M, Morelli A, Baiano S, Carnuccio R, Fuggetta MP, Morelli F./titolo:Simvastatin inhibits the expression of stemness-related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton./doi:10.3892%2Fijo.2017.4158/rivista:International journal of oncology/anno:2017/pagina_da:1851/pagina_a:1859/intervallo_pagine:1851–1859/volume:51
Statins are a class of drugs that inhibit the rate-limiting steps in the cholesterol biosynthesis pathway. They act by inhibiting 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate. Blocking of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5ab265883526d4317032798d0db149
http://hdl.handle.net/11588/693571
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5
2-hydroxy-8-methyl-1,7-dioxaspiro[5.5]undec-3-en-5-one: a Natural-Product-Inspired Spiroketal with in vivo Efficacy in Mouse Model of Melanoma
Autor: Pietro Spanu, Maria Pia Fuggetta, Fausta Ulgheri, Paola Carta, Francesco Deligia, Manuela Zonfrillo, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, Franco Morelli
Publikováno v: Conferenza di Dipartimento DSCTM 2017, Alghero, 19/10/2017,20/10/2017
info:cnr-pdr/source/autori:Pietro Spanu, Maria Pia Fuggetta,Fausta Ulgheri, Paola Carta, Francesco Deligia, Manuela Zonfrillo, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, and Franco Morelli/congresso_nome:Conferenza di Dipartimento DSCTM 2017/congresso_luogo:Alghero/congresso_data:19%2F10%2F2017,20%2F10%2F2017/anno:2017/pagina_da:/pagina_a:/intervallo_pagine
We have synthesised and identified a new promising antitumor agent with in vivo activity on a murine melanoma model. Compound 1 showed potent dose-dependent antitumor efficacy in syngenic C57Black mice murine model of melanoma, suppressing the tumor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ac6fb780ee6b410a93317f005f300015
https://publications.cnr.it/doc/380230
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6
SIMVASTATIN REDUCES MELANOMA PROGRESSION IN A MURINE MODEL
Autor: Mario Zanfardino, Anna De Filippis, Salvatore Baiano, Rosanna De Cicco, Franco Morelli, Elisabetta Buommino, Carmine Spampanato, Adriano Barra
Publikováno v: International Journal of Oncology
International Journal of Oncology (Athens) 43 (2013): 1763–1770. doi:10.3892/ijo.2013.2126
info:cnr-pdr/source/autori:Zanfardino M, Spampanato C, De Cicco R, Buommino E, De Filippis A, Baiano S, Barra A and Morelli F./titolo:Simvastatin reduces melanoma progression in a murine model/doi:10.3892%2Fijo.2013.2126/rivista:International Journal of Oncology (Athens)/anno:2013/pagina_da:1763/pagina_a:1770/intervallo_pagine:1763–1770/volume:43
Statins are a class of drugs that inhibit the rate-limiting step in the cholesterol biosynthetic pathway and show an anticancer effect, probably through the inhibition of cells proliferation. To date, the exact mechanism at basis of cancer cells grow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369bc4e11fa0ad7d02d3b5c1e5a0b967
http://hdl.handle.net/11591/200601
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