Výsledky vyhledávání - "Rosanna Cavagnoli"

Bbr 2778, an Aza-anthracenedione Endowed with Preclinical Anticancer Activity and Lack of Delayed Cardiotoxicity

Autor: Ennio Cavalletti, Luca Crippa, Ernesto Menta, Rosanna Cavagnoli, Silvano Spinelli, Gino Beggiolin, Eleonora Randisi, Giuliani F, Gabriella Pezzoni, Carla Manzotti, Dante Torriani, Franca Sala

Publikováno v: Tumori Journal. 87:407-416

With the aim to provide second-generation anthracenedione analogues endowed with reduced side effects and a wider spectrum of action than mitoxantrone and doxorubicin, a large number of new molecules bearing nitrogen atoms in the chromophore was synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37506c85336bcb3d4633a65945b89681
https://doi.org/10.1177/030089160108700611

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Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone

Autor: Luca Crippa, Franca Sala, Ornella Bellini, Norberto Oggioni, Patrizia Mainardi, Rosanna Cavagnoli, Ennio Cavalletti

Publikováno v: Investigational new drugs. 25(3)

Anthracyclines and anthracenediones are important oncotherapeutics; however, their use is associated with irreversible and cumulative cardiotoxicity. A novel aza-anthracenedione, pixantrone (BBR 2778), was developed to reduce treatment-related cardio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26e8f529bfff9c7a74bbd4b55022e38
https://pubmed.ncbi.nlm.nih.gov/17285358

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