Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells

Autor: Ancély F. Dos Santos, Alex Inague, Gabriel S. Arini, Letícia F. Terra, Rosangela A. M. Wailemann, André C. Pimentel, Marcos Y. Yoshinaga, Ricardo R. Silva, Divinomar Severino, Daria Raquel Q. de Almeida, Vinícius M. Gomes, Alexandre Bruni-Cardoso, Walter R. Terra, Sayuri Miyamoto, Maurício S. Baptista, Leticia Labriola

Publikováno v: Cell Death and Disease, Vol 11, Iss 12, Pp 1-12 (2020)

Abstract Lack of effective treatments for aggressive breast cancer is still a major global health problem. We have previously reported that photodynamic therapy using methylene blue as photosensitizer (MB-PDT) massively kills metastatic human breast

Externí odkaz: https://doaj.org/article/d454c2ad322f485dbf8c42ec308495e3

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

Autor: Matheus Henrique Dias, Anoek Friskes, Siying Wang, Joao M. Fernandes Neto, Frank van Gemert, Soufiane Mourragui, Hendrik J. Kuiken, Sara Mainardi, Daniel Alvarez-Villanueva, Cor Lieftink, Ben Morris, Anna Dekker, Emma van Dijk, Chrysa Papagianni, Marcelo S. da Silva, Robin Jansen, Antonio Mulero-Sánchez, Elke Malzer, August Vidal, Cristina Santos, Ramón Salazar, Rosangela A. M. Wailemann, Thompson E. P. Torres, Giulia De Conti, Jonne A. Raaijmakers, Petur Snaebjornsson, Shengxian Yuan, Wenxin Qin, John S. Kovach, Hugo A. Armelin, Hein te Riele, Alexander van Oudenaarden, Haojie Jin, Roderick L. Beijersbergen, Alberto Villanueva, Rene H. Medema, Rene Bernards

Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a1e3875a49631c0a488ddbe547c772b
https://doi.org/10.1101/2023.02.06.527335

Necroptosis activation is associated with greater methylene blue‑photodynamic therapy‑induced cytotoxicity in human pancreatic ductal adenocarcinoma cells

Autor: Daria R. Q. de Almeida, Ancély F. dos Santos, Rosangela A. M. Wailemann, Letícia F. Terra, Vinícius M. Gomes, Gabriel S. Arini, Ester R. M. Bertoldi, Eduardo M. Reis, Maurício S. Baptista, Leticia Labriola

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fd0d462e4e3f9fb02561424497e0ab

HSPB1 influences mitochondrial respiration in ER-stressed beta cells

Autor: Vinícius M. Gomes, Livia Rosa-Fernandes, Martin R. Larsen, Leticia Labriola, Simon Ngao Mule, Rosangela A. M. Wailemann, Giuseppe Palmisano, Janaina Macedo-da-Silva

Publikováno v: Mule, S N, Gomes, V D M, Wailemann, R A M, Macedo-da-Silva, J, Rosa-Fernandes, L, Larsen, M R, Labriola, L & Palmisano, G 2021, ' HSPB1 influences mitochondrial respiration in ER-stressed beta cells ', Biochimica et Biophysica Acta-Proteins and Proteomics, vol. 1869, no. 9, 140680 . https://doi.org/10.1016/j.bbapap.2021.140680
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Beta-cell death and dysfunction are involved in the development of type 1 and 2 diabetes. ER-stress impairs beta-cells function resulting in pro-apoptotic stimuli that promote cell death. Hence, the identification of protective mechanisms in response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2af094cf0383058ff54ea2d48efc7c
https://portal.findresearcher.sdu.dk/da/publications/888f688e-0903-430f-a4cd-1b9691a077f1

Fluence Rate Determines PDT Efficiency in Breast Cancer Cells Displaying Different GSH Levels

Autor: Leticia Labriola, Letícia Ferreira Terra, Daria Raquel Queiroz de Almeida, Rosangela A. M. Wailemann, Vinícius M. Gomes, Mauricio S. Baptista, Ancély Ferreira dos Santos, Felipe Gustavo Ravagnani, Gabriel S. Arini

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Photodynamic therapy (PDT) appears as a promising alternative in the treatment of breast cancer since it can be highly effective in curing cancer while preserving normal tissue. However, predicting outcomes in PDT still constitutes a great challenge.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19b42d392f7098b6be9618a00e97ef5
https://doi.org/10.1111/php.13182