Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rosane B DeOliveira"'
Autor:
Sunita Gulati, Frank J Beurskens, Bart-Jan de Kreuk, Marcel Roza, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Nancy A Nowak, Ronald P Taylor, Marina Botto, Xianbao He, Robin R Ingalls, Trent M Woodruff, Wen-Chao Song, Janine Schuurman, Peter A Rice, Sanjay Ram
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000323 (2019)
Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice. C
Externí odkaz:
https://doaj.org/article/d50d01ed75774b0d843c0e7549972158
Autor:
Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B. DeOliveira, Jutamas Shaughnessy, Lisa A. Lewis, Peter A. Rice, Pär Comstedt, Sanjay Ram
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTA safe and effective vaccine is urgently needed to combat the global threat of multidrug-resistant (MDR) Neisseria gonorrhoeae. We screened 26 gonococcal proteins discovered by an artificial intelligence-driven platform called Efficacy Discri
Externí odkaz:
https://doaj.org/article/04fed7bbb74b447cb687510aff5f200b
Autor:
Jutamas Shaughnessy, Aleyo Chabeda, Y. Tran, Bo Zheng, Nancy Nowak, Carolynn Steffens, Rosane B. DeOliveira, Sunita Gulati, Lisa A. Lewis, James Maclean, John A. Moss, Keith L. Wycoff, Sanjay Ram
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Novel therapeutics against the global threat of multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococci evade killing by complement by binding factor H (FH), a key inhibitor of the alternative pathway. FH comprises 20 short consensus
Externí odkaz:
https://doaj.org/article/f3abdcbc9c494fb6ab5c5b211e92670a
Publikováno v:
ImmunoHorizons. 3:519-530
Terminal complement pathway inhibition at the level of C5 alleviates symptoms of several diseases associated with complement overactivation. However, C5 blockade is associated with an increased risk of invasive meningococcal disease despite immunizat
Autor:
Rosane B. DeOliveira, Jutamas Shaughnessy, Y. Tran, Keith L. Wycoff, James Maclean, Bo Zheng, Wen-Chao Song, Sunita Gulati, Sanjay Ram
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Novel therapeutics against the global threat of multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococci possess several mechanisms to evade killing by human complement, including binding of factor H (FH), a key inhibitor of the alter
Autor:
George W. Reed, Bo Zheng, Jutamas Shaughnessy, Peter A. Rice, Michael W. Pennington, Darrick Carter, Andrzej Czerwinski, Nancy A. Nowak, Rosane B. DeOliveira, Sunita Gulati, Sanjay Ram
Publikováno v:
mBio, Vol 10, Iss 6, p e02552-19 (2019)
mBio
mBio, Vol 10, Iss 6 (2019)
mBio
mBio, Vol 10, Iss 6 (2019)
Neisseria gonorrhoeae has become resistant to most antibiotics. The incidence of gonorrhea is also sharply increasing. A safe and effective antigonococcal vaccine is urgently needed. Lipooligosaccharide (LOS), the most abundant outer membrane molecul
Autor:
Rosane B. DeOliveira, Sunita Gulati, Sanjay Ram, Jutamas Shaughnessy, Peter A. Rice, Lisa A. Lewis
Publikováno v:
Immunobiology. 221:1110-1123
Novel therapies are urgently needed to combat the global threat of multidrug-resistant pathogens. Complement forms an important arm of innate defenses against infections. In physiological conditions, complement activation is tightly controlled by sol
Autor:
Trent M. Woodruff, Xianbao He, Jutamas Shaughnessy, Marcel Roza, Janine Schuurman, Frank J. Beurskens, Bart-Jan de Kreuk, Peter A. Rice, Robin R. Ingalls, Nancy A. Nowak, Wen-Chao Song, Sunita Gulati, Sanjay Ram, Bo Zheng, Ronald P. Taylor, Marina Botto, Rosane B. DeOliveira
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 6, p e3000323 (2019)
PLoS Biology, Vol 17, Iss 6, p e3000323 (2019)
Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e53b32e5caa49cb9b1f637e81cd869
http://hdl.handle.net/10044/1/71493
http://hdl.handle.net/10044/1/71493
Publikováno v:
ImmunoHorizons. 3(11)
Terminal complement pathway inhibition at the level of C5 alleviates symptoms of several diseases associated with complement overactivation. However, C5 blockade is associated with an increased risk of invasive meningococcal disease despite immunizat
Autor:
Marina Botto, Lisa A. Lewis, George W. Reed, Peter A. Rice, Sunita Gulati, Sanjay Ram, Jutamas Shaughnessy, Bo Zheng, Severin Gose, Isaac Bass, Caleb Carr, Rosane B. DeOliveira
Novel therapeutics against multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococcal lipooligosaccharide often expresses lacto-N-neotetraose (LNnT), which becomes sialylated in vivo, enhancing factor H (FH) binding and contributing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d797dd4729479ae908df7c2aa4efe163
https://europepmc.org/articles/PMC6200640/
https://europepmc.org/articles/PMC6200640/