Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rosana I. Reis"'
Autor:
Kamel El Omari, Ramona Duman, Vitaliy Mykhaylyk, Christian M. Orr, Merlyn Latimer-Smith, Graeme Winter, Vinay Grama, Feng Qu, Kiran Bountra, Hok Sau Kwong, Maria Romano, Rosana I. Reis, Lutz Vogeley, Luca Vecchia, C. David Owen, Sina Wittmann, Max Renner, Miki Senda, Naohiro Matsugaki, Yoshiaki Kawano, Thomas A. Bowden, Isabel Moraes, Jonathan M. Grimes, Erika J. Mancini, Martin A. Walsh, Cristiane R. Guzzo, Raymond J. Owens, E. Yvonne Jones, David G. Brown, Dave I. Stuart, Konstantinos Beis, Armin Wagner
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by mea
Externí odkaz:
https://doaj.org/article/8684a241320c432f8b25757e0cf6d695
Autor:
Tristan O. C. Kwan, Stefan A. Kolek, Amy E. Danson, Rosana I. Reis, Ines S. Camacho, Patrick D. Shaw Stewart, Isabel Moraes
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Structure-function relationships of biological macromolecules, in particular proteins, provide crucial insights for fundamental biochemistry, medical research and early drug discovery. However, production of recombinant proteins, either for structure
Externí odkaz:
https://doaj.org/article/cd9d8a84350c4cf383e74b57f43a67a3
Autor:
Rosana I. Reis, Isabel Moraes
Publikováno v:
Biology, Vol 9, Iss 11, p 400 (2020)
Membrane proteins play a crucial role in cell physiology by participating in a variety of essential processes such as transport, signal transduction and cell communication. Hence, understanding their structure–function relationship is vital for the
Externí odkaz:
https://doaj.org/article/092e69347be54d27aba34e8364df78b8
Autor:
Antonio J. Costa-Filho, Patricia M. Dijkman, Juan C. Muñoz-García, Anthony Watts, Rosana I. Reis, Steven Lavington, Daniel Yin, Phillip J. Stansfeld, Patricia S. Kumagai
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Science Advances
Universidade de São Paulo (USP)
instacron:USP
Science Advances
Helix 8 of the GPCR neurotensin receptor 1 is stabilised by specific lipid-protein interactions.
G protein–coupled receptors (GPCRs) are the largest and pharmaceutically most important class of membrane proteins encoded in the human genome, ch
G protein–coupled receptors (GPCRs) are the largest and pharmaceutically most important class of membrane proteins encoded in the human genome, ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483a0810dd023e844410834f47a9deb0
Autor:
Sylvie Rodrigues-Ferreira, Mohamed Abdelkarim, Patricia Dillenburg-Pilla, Anny-Claude Luissint, Anne di-Tommaso, Frédérique Deshayes, Carmen Lucia S Pontes, Angie Molina, Nicolas Cagnard, Franck Letourneur, Marina Morel, Rosana I Reis, Dulce E Casarini, Benoit Terris, Pierre-Olivier Couraud, Claudio M Costa-Neto, Mélanie Di Benedetto, Clara Nahmias
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35667 (2012)
Breast cancer metastasis is a leading cause of death by malignancy in women worldwide. Efforts are being made to further characterize the rate-limiting steps of cancer metastasis, i.e. extravasation of circulating tumor cells and colonization of seco
Externí odkaz:
https://doaj.org/article/080dd26831f04bd1855e2d4ec677f9ea
Autor:
Larissa Miranda Pereira, Dulce Elena Casarini, Renato A. Mortara, Ana Lucia Campanha-Rodrigues, Maria Claudina Camargo de Andrade, Claudio M. Costa-Neto, Marie Doki Nogueira, Lucas T. Parreiras-e-Silva, Rosana I. Reis
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Hypertension is a global health problem, and angiotensin I (ANG I)-converting enzyme (ACE) inhibitors are largely used to control this pathology. Recently, it has been shown that ACE can also act as a transducer signal molecule when its inhibitors or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc85545598623d90c78331f5f15c9d65
https://doi.org/10.1152/ajpcell.00012.2016
https://doi.org/10.1152/ajpcell.00012.2016
Autor:
Rosana I. Reis, Dulce Elena Casarini, Paula C. Huber, Lys Angela Mendes, Ricardo V. Marques, Claudio M. Costa-Neto, Luis Gustavo Robello, Adriana Barrinha Fernandes, Patricia Tambarussi Baraldi, Fernanda Aparecida Ronchi
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Hypertension has been associated as a pathogenesis involved in the renin angiotensin system. The most commonly used drug to block the AT1R, is Losartan which has specific pharmacophore groups such as imidazole and biphenyl. However the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ecf05779b1be77e9e01229d57ead41
https://doi.org/10.2174/1874842201603010056
https://doi.org/10.2174/1874842201603010056
Autor:
David McMillan, Luis Castro, Catherine Vandenplas, Zara A. Sands, Marco Kriek, Alistair James Henry, Anthony Watts, Martyn Wood, Juan F. Bada Juarez, Juan C. Muñoz-García, Rosana I. Reis, Richard J. K. Taylor
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183152
Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in the central nervous system (CNS). These receptors mediate physiological functions ranging from voluntary movement and reward recognition to hormonal regulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c265a2e4853e413086272cbbb48c16c
https://doi.org/10.1016/j.bbamem.2019.183152
https://doi.org/10.1016/j.bbamem.2019.183152
Autor:
Anthony Watts, Richard J. K. Taylor, Alistair James Henry, Juan C. Muñoz-García, Rosana I. Reis
Saturation transfer difference (STD) NMR spectroscopy is one of the most popular ligand-based NMR techniques for the study of protein-ligand interactions. This is due to its robustness and the fact that it is focused on the signals of the ligand, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd64f7a9c13ccee9f90668d13d9cb52
https://doi.org/10.1002/cbic.201800078
https://doi.org/10.1002/cbic.201800078
Autor:
Sachdev S. Sidhu, Brian K. Kobilka, Xin Chen, Li-Yin Huang, Arun K. Shukla, Austin N. Oleskie, Minjung Choi, Sheng Li, Ling Ling Gu, Anthony A. Kossiakoff, Jiang Qian, Gerwin Westfield, Rosana I. Reis, Robert J. Lefkowitz, Shohei Koide, Alem W. Kahsai, Georgios Skiniotis, Jin Ming Shan, Adi Blanc, Prachi Tripathi-Shukla, Pawel A. Penczek, Cui Rong Liang, Rachel Hanna, Anne M. Dosey, Bjoern U. Klink, Xiao Jie Yao, Kunhong Xiao, Min Su, Virgil L. Woods
Publikováno v:
Nature
Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex. Much has been learned about the structure of G-protein-cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f682eb622e9146fca04b1ae7ebd9fa7d
https://doi.org/10.1038/nature13430
https://doi.org/10.1038/nature13430