Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rosamary Ramentol"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain. Here authors reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between
Externí odkaz:
https://doaj.org/article/2e930f15eab946698c97b37cf9434cbf
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2908-2918 (2018)
Summary: Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators. In this study, we describe dual independent activating effects of negatively charged PUFA analogs on KV7.1
Externí odkaz:
https://doaj.org/article/1aad31143aca4177bd176e648363e273
Publikováno v:
Journal of General Physiology. 155
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to the rhythmic firing of pacemaker neurons and cardiomyocytes. Mutations in HCN channels are associated with cardiac arrhythmia and epilepsy. HCN channels belong to the su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26e2f9cdf35a11a00f115b9c807ca5e5
https://doi.org/10.1085/jgp.202213170
https://doi.org/10.1085/jgp.202213170
Publikováno v:
Proc Natl Acad Sci U S A
Rhythmic activity in pacemaker cells, as in the sino-atrial node in the heart, depends on the activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. As in depolarization-activated K(+) channels, the fourth transmembrane seg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0917242958f576172de0b9c896eac3c1
https://doi.org/10.1073/pnas.2102036118
https://doi.org/10.1073/pnas.2102036118
Publikováno v:
Biophysical Journal. 121:295a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00c61b75997ac7856403a7903e2ba92
https://doi.org/10.1016/j.bpj.2021.11.1276
https://doi.org/10.1016/j.bpj.2021.11.1276
Publikováno v:
Biophysical Journal. 116:543a-544a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8eb88931a1907798c5fb53c1a4fddd5
https://doi.org/10.1016/j.bpj.2018.11.2921
https://doi.org/10.1016/j.bpj.2018.11.2921
Autor:
Rosamary Ramentol, Sara I. Liin, Rene Barro-Soria, Robert S. Kass, Marta E. Perez, H. Peter Larsson
Publikováno v:
Proceedings of the National Academy of Sciences. 114
KCNE β-subunits assemble with and modulate the properties of voltage-gated K+ channels. In the heart, KCNE1 associates with the α-subunit KCNQ1 to generate the slowly activating, voltage-dependent potassium current (IKs) in the heart that controls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac27eb78d8c16d57de14b830aff3651
https://doi.org/10.1073/pnas.1710335114
https://doi.org/10.1073/pnas.1710335114
Publikováno v:
Biophysical Journal. 114:121a-122a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c010cff2b4a2798e078901c4d278d4b
https://doi.org/10.1016/j.bpj.2017.11.695
https://doi.org/10.1016/j.bpj.2017.11.695