Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Rosamaria Ruggieri"'
Autor:
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Abstract Background Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therape
Externí odkaz:
https://doaj.org/article/c1a6ee476fc8474f99b9f1bb007fbe07
Autor:
Zonghui Ding, Harshil Dhruv, Aneta Kwiatkowska-Piwowarczyk, Rosamaria Ruggieri, Jean Kloss, Marc Symons, Patrick Pirrotte, Jennifer M. Eschbacher, Nhan L. Tran, Joseph C. Loftus
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 10, Pp 1045-1058 (2018)
Glioblastoma multiforme (GBM) is the most common type of malignant brain tumors in adults and has a dismal prognosis. The highly aggressive invasion of malignant cells into the normal brain parenchyma renders complete surgical resection of GBM tumors
Externí odkaz:
https://doaj.org/article/d137ed84ba9c4ae983ff2f4b5a25f3c4
Autor:
Michelle De Witt, Alexander Gamble, Derek Hanson, Daniel Markowitz, Caitlin Powell, Saleh Al Dimassi, Mark Atlas, John Boockvar, Rosamaria Ruggieri, Marc Symons
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 50-56 (2017)
Abstract The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain tumor tissue, and moreover, it
Externí odkaz:
https://doaj.org/article/23f5ae1dbd7c45a4a3d2781470897b97
Autor:
Ian S Miller, Sebastien Didier, David W Murray, Tia H Turner, Magimairajan Issaivanan, Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95885 (2014)
Glioblastoma is the most malignant and lethal form of astrocytoma, with patients having a median survival time of approximately 15 months with current therapeutic modalities. It is therefore important to identify novel therapeutics. There is mounting
Externí odkaz:
https://doaj.org/article/c78d1e4261434b10b2046c406410ba86
Autor:
Harina Vin, Sandra S Ojeda, Grace Ching, Marco L Leung, Vida Chitsazzadeh, David W Dwyer, Charles H Adelmann, Monica Restrepo, Kristen N Richards, Larissa R Stewart, Lili Du, Scarlett B Ferguson, Deepavali Chakravarti, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L Curry, Kevin B Kim, Ana M Ciurea, Madeleine Duvic, Victor G Prieto, Stephen E Ullrich, Kevin N Dalby, Elsa R Flores, Kenneth Y Tsai
Publikováno v:
eLife, Vol 2 (2013)
Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cu
Externí odkaz:
https://doaj.org/article/b82986af3d064ca596c82909e620f375
Autor:
Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons, Shan Sun, Mingzhu He, Lisa Rosen, Magimairajan Vanan, Timothy C. Ryken, Michael E. Berens, Nhan L. Tran, Caitlin Powell, Daniel Markowitz
Lack of radiosensitization of M443 on normal brain cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9996a2a472a5ac4babc093a2e3e37c6f
https://doi.org/10.1158/1535-7163.22508880.v1
https://doi.org/10.1158/1535-7163.22508880.v1
Autor:
Kenneth Y. Tsai, Nizar M. Tannir, Naifa L. Busaidy, Madeleine Duvic, Ana M. Ciurea, Jonathan L. Curry, Rosamaria Ruggieri, Manuela Baccarini, Karin Ehrenreiter, Haiching Ma, David W. Dwyer, Vida Chitsazzadeh, Charles H. Adelmann, Sandra S. Ojeda, Grace Ching, Harina Vin
PDF - 69KB, In-vitro kinase assays were performed against sorafenib with a staurosporine positive control across a concentration range of 0.5 nM to 10 μM). Blank values are those for which no significant inhibition occurred over the entire concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88de25d705152f0908a5d78921600fc
https://doi.org/10.1158/1535-7163.22503256.v1
https://doi.org/10.1158/1535-7163.22503256.v1
Autor:
Kenneth Y. Tsai, Nizar M. Tannir, Naifa L. Busaidy, Madeleine Duvic, Ana M. Ciurea, Jonathan L. Curry, Rosamaria Ruggieri, Manuela Baccarini, Karin Ehrenreiter, Haiching Ma, David W. Dwyer, Vida Chitsazzadeh, Charles H. Adelmann, Sandra S. Ojeda, Grace Ching, Harina Vin
PDF - 1060KB, Sorafenib suppresses JNK-dependent apoptosis as assessed by cleaved caspase 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f52bce56824158bd5240f1f3eaebe33
https://doi.org/10.1158/1535-7163.22503259
https://doi.org/10.1158/1535-7163.22503259
Autor:
Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons, Shan Sun, Mingzhu He, Lisa Rosen, Magimairajan Vanan, Timothy C. Ryken, Michael E. Berens, Nhan L. Tran, Caitlin Powell, Daniel Markowitz
Legends to Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0274bca6b7311f1d51a8ebe393342fd3
https://doi.org/10.1158/1535-7163.22508868
https://doi.org/10.1158/1535-7163.22508868
Autor:
Zonghui Ding, Joseph C. Loftus, Rosamaria Ruggieri, Shannon P. Fortin Ensign, Zhiwan Dong, Yuping Yang, Hemragul Sabit, Nhan L. Tran, Jean Kloss, Marc Symons, Mitsutoshi Nakada
Publikováno v:
Am J Pathol
Glioblastoma (GBM) is the most common primary malignant brain cancer in adults. A hallmark of GBM is aggressive invasion of tumor cells into the surrounding normal brain. Both the current standard of care and targeted therapies have largely failed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835467a497c88c4a36d860e3ccb425e8
https://doi.org/10.1016/j.ajpath.2020.07.005
https://doi.org/10.1016/j.ajpath.2020.07.005