p53-Independent Apoptosis and p53-Dependent Block of DNA Rereplication Following Mitotic Spindle Inhibition in Human Cells

Autor: Enrico Cundari, Patrizia Lavia, Marcel Tuynder, Perrine Caillet-Fauquet, Rosamaria Mangiacasale, Suzanne Mousset, Micheline Kirsch-Volders, Martina Casenghi, Azeddine Elhajouji

Publikováno v: Experimental cell research 250 (1999): 339–350. doi:10.1006/excr.1999.4554
info:cnr-pdr/source/autori:Casenghi, M; Mangiacasale, R; Tuynder, M; Caillet-Fauquet, P; Elhajouji, A; Lavia, P; Mousset, S; Kirsch-Volders, M; Cundari, E/titolo:p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells/doi:10.1006%2Fexcr.1999.4554/rivista:Experimental cell research/anno:1999/pagina_da:339/pagina_a:350/intervallo_pagine:339–350/volume:250

We have studied the response of human transformed cells to mitotic spindle inhibition. Two paired cell lines, K562 and its parvovirus-resistant KS derivative clone, respectively nonexpressing and expressing p53, were continuously exposed to nocodazol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce78629a9de793cc7cd6dd7d7dc35544
https://doi.org/10.1006/excr.1999.4554

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells

Autor: Emanuele Roscioli, Wilhelmina Maria Rensen, Antonio Tedeschi, Marilena Ciciarello, Rosamaria Mangiacasale, Patrizia Lavia

Publikováno v: Journal of cell science 120 (2007): 3748–3761. doi:10.1242/jcs.009308
info:cnr-pdr/source/autori:Tedeschi A, Ciciarello M, Mangiacasale R, Roscioli E, Rensen WM, Lavia P./titolo:RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells./doi:10.1242%2Fjcs.009308/rivista:Journal of cell science/anno:2007/pagina_da:3748/pagina_a:3761/intervallo_pagine:3748–3761/volume:120

The GTPase RAN has an established role in spindle assembly and in mitotic progression, although not all mechanisms are fully understood in somatic cells. Here, we have downregulated RAN-binding protein 1 (RANBP1), a RAN partner that has highest abund

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f69cb941e3c545ede65f62bad5fd17
http://hdl.handle.net/11585/385119

p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint are ATM-Dependent and Require Serine 15 Phosphorylation

Autor: Rosamaria Mangiacasale, Antonella Palena, Patrizia Lavia, Marilena Ciciarello, A. Tritarelli, Silvia Soddu, Enrico Cundari, Elisa Oricchio

Publikováno v: Molecular biology of the cell 15 (2004): 3751–3757.
info:cnr-pdr/source/autori:Tritarelli A, Oricchio E, Ciciarello M, Mangiacasale R, Palena A, Lavia P, Soddu S, Cundari E./titolo:p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint are ATM-Dependent and Require Serine 15 Phosphorylation./doi:/rivista:Molecular biology of the cell/anno:2004/pagina_da:3751/pagina_a:3757/intervallo_pagine:3751–3757/volume:15

We recently demonstrated that the p53 oncosuppressor associates to centrosomes in mitosis and this association is disrupted by treatments with microtubule-depolymerizing agents. Here, we show that ATM, an upstream activator of p53 after DNA damage, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dea6d326143de635cea8c2c10e64af8
https://publications.cnr.it/doc/11467

Mouse early embryos obtained by natural breeding or in vitro fertilization display a differential sensitivity to extremely low-frequency electromagnetic fields

Autor: Rosamaria Mangiacasale, Rosanna Beraldi, Ilaria Sciamanna, Rodolfo Lorenzini, Corrado Spadafora

Publikováno v: Mutation research. 538(1-2)

We have investigated the sensitivity of pre-implantation embryos obtained by natural breeding (NB) or in vitro fertilization (IVF) to extremely low-frequency magnetic fields (ELF-MF). Fertilized eggs obtained by NB were removed from mothers 12h after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9b12e587738eb1b74ebb2a001ae2e4
https://pubmed.ncbi.nlm.nih.gov/12834765

p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle

Autor: M.Z. Limongi, Enrico Cundari, Marco D'Angelo, Marilena Ciciarello, Patrizia Lavia, Silvia Soddu, Martina Casenghi, Rosamaria Mangiacasale

Publikováno v: 276 (2001): 19205–19213.
info:cnr-pdr/source/autori:Ciciarello M 1, Mangiacasale R 1, Casenghi M 1, Zaira Limongi M 1, D'Angelo M 2, Soddu S 2, Lavia P 1, Cundari E 1./titolo:p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle./doi:/rivista:/anno:2001/pagina_da:19205/pagina_a:19213/intervallo_pagine:19205–19213/volume:276

Growing evidence indicates a central role for p53 in mediating cell cycle arrest in response to mitotic spindle defects so as to prevent rereplication in cells in which the mitotic division has failed. Here we report that a transient inhibition of sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c9aa0f0a1058cb420141b260860a99
https://pubmed.ncbi.nlm.nih.gov/11376010