Kinetics of nuclear phosphorylation ( -H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin C

Autor: Sara Castagna, Caterina Giovannini, Erika Filomeni, Serena Testi, Alessia Azzarà, Sara Lombardi, Roberto Scarpato, Francesco Ghetti, Antonio Tomei, Chiara Pirillo, Rosamaria Aliotta

Publikováno v: Mutagenesis 28 (2013): 465–473. doi:10.1093/mutage/get024
info:cnr-pdr/source/autori:Scarpato R, Castagna S, Aliotta R, Azzara A, Ghetti F, Filomeni E, Giovannini C, Pirillo C, Testi S, Lombardi S, Tomei A/titolo:Kinetics of nuclear phosphorylation (-H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin C/doi:10.1093%2Fmutage%2Fget024/rivista:Mutagenesis/anno:2013/pagina_da:465/pagina_a:473/intervallo_pagine:465–473/volume:28

After double-strand break induction, formation of ?-H2AX foci due to phosphorylation at Ser-139 of histone H2AX represents an early event of the DNA damage response (DDR). ?-H2AX foci are then rapidly dephosphorylated as signal for the subsequent rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be38555202194c662f8f2798eab5b820
https://doi.org/10.1093/mutage/get024