Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rosalynn C. Molden"'
Autor:
Benjamin A. Garcia, Katarzyna Kulej, Ben E. Black, Emigdio D. Reyes, G. Scott Worthen, Matthew D. Weitzman, Christin Herrmann, Patrick Hearing, Neha J. Pancholi, Nikolina Sekulic, Joana Petrescu, Philomena Ostapchuk, Daniel M. Blumenthal, Steven H. Seeholzer, Daphne C. Avgousti, Rosalynn C. Molden, Andrew J. Paris
Publikováno v:
Nature. 535:173-177
Viral proteins mimic host protein structure and function to redirect cellular processes and subvert innate defenses. Small basic proteins compact and regulate both viral and cellular DNA genomes. Nucleosomes are the repeating units of cellular chroma
Publikováno v:
Molecular & Cellular Proteomics. 15:834-853
Protein phosphorylation, one of the most common and important modifications of acute and reversible regulation of protein function, plays a dominant role in almost all cellular processes. These signaling events regulate cellular responses, including
Publikováno v:
J Biol Chem
We present a system-level analysis of proteome, phosphoproteome, and chromatin state of precursors of muscle cells (myoblasts) differentiating into specialized myotubes. Using stable isotope labeling of amino acids in cell culture and nano-liqud chro
Autor:
Yumiao Han, Samuel Wein, Zuo-Fei Yuan, Shichong Liu, Xing Jun Cao, Shu Lin, Benjamin A. Garcia, Leila Afjehi-Sadat, Anna M. Arnaudo, Xiaoshi Wang, Laura Mae P. Britton, Simone Sidoli, Natarajan V. Bhanu, Rosalynn C. Molden, Kelly R. Karch, Michelle Gonzales-Cope
Publikováno v:
PROTEOMICS. 15:1459-1469
Mass spectrometry (MS)-based proteomics has become the most utilized tool to characterize histone post-translational modifications (PTMs). Since histones are highly enriched in lysine and arginine residues, lysine derivatization has been developed to
Publikováno v:
Journal of Proteome Research
Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer i
Publikováno v:
Nature Chemistry. 4:941-946
RNA performs important cellular functions in contemporary life forms. Its ability to act both as a catalyst and a storage mechanism for genetic information is also an important part of the RNA world hypothesis. Compartmentalization within modern cell
Publikováno v:
Epigenetics & Chromatin
Background Histone isoforms and their post-translational modifications (PTMs) play an important role in the control of many chromatin-related processes including transcription and DNA damage. Variants of histones H2A and H3 have been studied in depth
Autor:
Shichong Liu, Benjamin A. Garcia, Natarajan V. Bhanu, Xing Jun Cao, Zuo-Fei Yuan, Rosalynn C. Molden, Shu Lin, Xiaoshi Wang, Simone Sidoli
Publikováno v:
Molecularcellular proteomics : MCP. 14(6)
Histone post-translational modifications contribute to chromatin function through their chemical properties which influence chromatin structure and their ability to recruit chromatin interacting proteins. Nanoflow liquid chromatography coupled with h
Autor:
Benjamin A. Garcia, Rosalynn C. Molden
Publikováno v:
Current Protocols in Protein Science
Histones are chromatin proteins that are highly modified with many different types of post-translational modifications. These modifications act in concert to regulate a number of chromatin-related processes. However, identification and quantification
Publikováno v:
Molecularcellular proteomics : MCP. 13(4)
Signals that control responses to stimuli and cellular function are transmitted through the dynamic phosphorylation of thousands of proteins by protein kinases. Many techniques have been developed to study phosphorylation dynamics, including several