Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Rosalyn W. Sayaman"'
Autor:
Rosalyn W. Sayaman, Mohamad Saad, Carolina Heimann, Donglei Hu, Khalid Kunji, Jessica Roelands, Denise M. Wolf, Scott Huntsman, Michele Ceccarelli, Vésteinn Thorsson, Elad Ziv, Davide Bedognetti
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101809- (2022)
Summary: Germline genetic variants modulate human immune response. We present analytical pipelines for assessing the contribution of hosts’ genetic background to the immune landscape of solid tumors using harmonized data from more than 9,000 patien
Externí odkaz:
https://doaj.org/article/0ca429312e1c4a1f8fe9a9562396dc10
Autor:
Nyasha Chambwe, Rosalyn W. Sayaman, Donglei Hu, Scott Huntsman, Anab Kemal, Samantha Caesar-Johnson, Jean C. Zenklusen, Elad Ziv, Rameen Beroukhim, Andrew D. Cherniack, Jian Carrot-Zhang, Ashton C. Berger, Seunghun Han, Matthew Meyerson, Jeffrey S. Damrauer, Katherine A. Hoadley, Ina Felau, John A. Demchok, Michael K.A. Mensah, Roy Tarnuzzer, Zhining Wang, Liming Yang, Theo A. Knijnenburg, A. Gordon Robertson, Christina Yau, Christopher Benz, Kuan-lin Huang, Justin Y. Newberg, Garrett M. Frampton, R. Jay Mashl, Li Ding, Alessandro Romanel, Francesca Demichelis, Wanding Zhou, Peter W. Laird, Hui Shen, Christopher K. Wong, Joshua M. Stuart, Alexander J. Lazar, Xiuning Le, Ninad Oak
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101586- (2022)
Summary: Differential mRNA expression between ancestry groups can be explained by both genetic and environmental factors. We outline a computational workflow to determine the extent to which germline genetic variation explains cancer-specific molecul
Externí odkaz:
https://doaj.org/article/58eb09142b5d45b991b34126ef4e9377
Autor:
Jessica Roelands, Raghvendra Mall, Hossam Almeer, Remy Thomas, Mahmoud G. Mohamed, Shahinaz Bedri, Salha Bujassoum Al-Bader, Kulsoom Junejo, Elad Ziv, Rosalyn W. Sayaman, Peter J. K. Kuppen, Davide Bedognetti, Wouter Hendrickx, Julie Decock
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Breast cancer largely dominates the global cancer burden statistics; however, there are striking disparities in mortality rates across countries. While socioeconomic factors contribute to population-based differences in mortality, they do no
Externí odkaz:
https://doaj.org/article/b9ef27825e2f4d69a5e91d3295cb1212
Autor:
Jian Carrot-Zhang, Seunghun Han, Wanding Zhou, Jeffrey S. Damrauer, Anab Kemal, Andrew D. Cherniack, Rameen Beroukhim, Ashton C. Berger, Matthew Meyerson, Katherine A. Hoadley, Ina Felau, Samantha Caesar-Johnson, John A. Demchok, Michael K.A. Mensah, Roy Tarnuzzer, Zhining Wang, Liming Yang, Jean C. Zenklusen, Nyasha Chambwe, Theo A. Knijnenburg, A. Gordon Robertson, Christina Yau, Christopher Benz, Kuan-lin Huang, Justin Newberg, Garret Frampton, R. Jay Mashl, Li Ding, Alessandro Romanel, Francesca Demichelis, Rosalyn W. Sayaman, Elad Ziv, Peter W. Laird, Hui Shen, Christopher K. Wong, Joshua M. Stuart, Alexander J. Lazar, Xiuning Le, Ninad Oak
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100766- (2021)
Summary: People of different ancestries vary in cancer risk and outcome, and their molecular differences may indicate sources of these variations. Determining the “local” ancestry composition at each genetic locus across ancestry-admixed populati
Externí odkaz:
https://doaj.org/article/57ccfed30daa47de8636a9bc5c03e2a0
Autor:
Stefan Hinz, Antigoni Manousopoulou, Masaru Miyano, Rosalyn W. Sayaman, Kristina Y. Aguilera, Michael E. Todhunter, Jennifer C. Lopez, Lydia L. Sohn, Leo D. Wang, Mark A. LaBarge
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103026- (2021)
Summary: Age is the major risk factor in most carcinomas, yet little is known about how proteomes change with age in any human epithelium. We present comprehensive proteomes comprised of >9,000 total proteins and >15,000 phosphopeptides from normal p
Externí odkaz:
https://doaj.org/article/e72f584687ea4298b6399b8a51b8f7ce
Autor:
Michael E. Todhunter, Masaru Miyano, Divya S. Moolamalla, Aleksandr Filippov, Rosalyn W. Sayaman, Mark A. LaBarge
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102253- (2021)
Summary: A long-standing constraint on organoid culture is the need to add exogenous substances to provide hydrogel matrix, which limits the study of fully human or fully native organoids. This paper introduces an approach to culture reconstituted ma
Externí odkaz:
https://doaj.org/article/11975e2bb4754e0d9d9633217366301e
Autor:
Jingxuan Shan, Aziz Chouchane, Younes Mokrab, Mohamad Saad, Salha Boujassoum, Rosalyn W. Sayaman, Elad Ziv, Noureddine Bouaouina, Yasmine Remadi, Sallouha Gabbouj, Jessica Roelands, Xiaojing Ma, Davide Bedognetti, Lotfi Chouchane
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Triple-negative breast cancer (TNBC) accounts for ~15–20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. The Chemokine (C-C motif) ligand 5 (CCL5) and its signaling pathway have been linked to
Externí odkaz:
https://doaj.org/article/4946a6389cb944f4bf59218bb7372cf5
Autor:
Jessica Roelands, Peter J. K. Kuppen, Eiman I. Ahmed, Raghvendra Mall, Tariq Masoodi, Parul Singh, Gianni Monaco, Christophe Raynaud, Noel F.C.C. de Miranda, Luigi Ferraro, Tatiana C. Carneiro-Lobo, Najeeb Syed, Arun Rawat, Amany Awad, Julie Decock, William Mifsud, Lance D. Miller, Shimaa Sherif, Mahmoud G. Mohamed, Darawan Rinchai, Marc Van den Eynde, Rosalyn W. Sayaman, Elad Ziv, Francois Bertucci, Mahir Abdulla Petkar, Stephan Lorenz, Lisa Sara Mathew, Kun Wang, Selvasankar Murugesan, Damien Chaussabel, Alexander L. Vahrmeijer, Ena Wang, Anna Ceccarelli, Khalid A. Fakhro, Gabriele Zoppoli, Alberto Ballestrero, Rob A.E.M. Tollenaar, Francesco M. Marincola, Jérôme Galon, Souhaila Al Khodor, Michele Ceccarelli, Wouter Hendrickx, Davide Bedognetti
Publikováno v:
Nature Medicine. 29:1273-1286
The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa27d4b0d2d4236a82ff6e6322e2eb9
https://doi.org/10.1038/s41591-023-02324-5
https://doi.org/10.1038/s41591-023-02324-5
Autor:
Mark Jesus M. Magbanua, Lamorna Brown Swigart, Ziad Ahmed, Rosalyn W. Sayaman, Derrick Renner, Ekaterina Kalashnikova, Gillian L. Hirst, Christina Yau, Denise M. Wolf, Wen Li, Amy L. Delson, Smita Asare, Minetta C. Liu, Kathy Albain, A. Jo Chien, Andres Forero-Torres, Claudine Isaacs, Rita Nanda, Debu Tripathy, Angel Rodriguez, Himanshu Sethi, Alexey Aleshin, Matthew Rabinowitz, Jane Perlmutter, W. Fraser Symmans, Douglas Yee, Nola M. Hylton, Laura J. Esserman, Angela M. DeMichele, Hope S. Rugo, Laura J. van ’t Veer
Publikováno v:
Cancer Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3f5cb5d242c1d2a9b392f722dfcdc6
https://doi.org/10.1016/j.ccell.2023.04.008
https://doi.org/10.1016/j.ccell.2023.04.008
Autor:
Michael E. Todhunter, Jennifer C. Lopez, Sundus F. Shalabi, Kai Kessenbrock, Tiina A Jokela, Masaru Miyano, Stefan Hinz, Victoria E. Seewaldt, Martha R. Stampfer, James C. Garbe, Mark A. LaBarge, Rosalyn W. Sayaman
Publikováno v:
Nature Aging. 1:838-849
We thank C. Thai, A. Sanchez, T. Chevez, A. Nunez and M. V. Robles for their help with tissue collection and clinical information from the women participating in our study. We also thank M. Miyano for assistance with immunofluorescence images, M. Bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96fbb0440f11d436e5fd29b5d51dbeb8
https://doi.org/10.1038/s43587-021-00104-9
https://doi.org/10.1038/s43587-021-00104-9