In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype

Autor: M L den Boer, Jochen Harbott, E. R. Van Wering, A H Loonen, Bruce M. Camitta, G. E. Janka-Schaub, Rosalyn Slater, W.-D. Ludwig, Rob Pieters, N L Ramakers-van Woerden, Anjo J.P. Veerman, H B Beverloo, Oskar A. Haas

Publikováno v: Leukemia, 18(3), 521-9. Nature Publishing Group
Ramakers-van Woerden, NL, Beverloo, HB, Veerman, A J P, Camitta, BM, Loonen, A H, van Wering, E R, Slater, RM, Harbott, J, den Boer, M L, Ludwig, WD, Haas, OA & Janka-Schaub, GE 2004, ' In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype. ', Leukemia, vol. 18, no. 3, pp. 521-9 . https://doi.org/10.1038/sj.leu.2403253
Leukemia, 18, 521-529. Nature Publishing Group

Acute lymphoblastic leukemia (ALL) in infants under 1 year is strongly associated with translocations involving 11q23 (MLL gene), CD10-negative B-lineage (proB) immunophenotype, and poor outcome. The present study analyses the relationship between ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb65991c3bb2238ae6d2e837d6e4829b
https://doi.org/10.1038/sj.leu.2403253

BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991–1996)

Autor: Rosalyn Slater, W.G. Kroes, A. J. P. Veerman, Jo Hermans, A. van der Does-van den Berg, E. R. Van Wering, W. A. Kamps, F.G.A.J. Hakvoort-Cammel, Jos P.M. Bökkerink, R.S. Weening, J.F. van Weerden, E. van den Berg

Publikováno v: Leukemia, 16, 6, pp. 1099-111
Leukemia, 16, 1099-111
Leukemia, 16(6), 1099-1111. Nature Publishing Group

Item does not contain fulltext Modern treatment strategies, consisting of intensive chemotherapy and cranial irradiation, have remarkably improved the prognosis for children with acute lymphoblastic leukemia. However, patients with a potential for cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95d09743f549d16c617d8a65abe9958
https://doi.org/10.1038/sj.leu.2402489

t(7;12)(q36;p13) and t(7;12)(q32;p13) – translocations involving ETV6 in children 18 months of age or younger with myeloid disorders

Autor: W.G. Kroes, Susana C. Raimondi, E. van den Berg, E van Drunen, Karel Hählen, A. van der Does-van den Berg, Daniel Olde Weghuis, Rosalyn Slater, H B Beverloo, E.M.E. Smit, Andrew J. Carroll, E. R. Van Wering

Publikováno v: Leukemia, 15(6), 915-920. Nature Publishing Group

Our retrospective karyotype review revealed two rare recurrent translocations affecting ETV6 (TEL): t(7;12)(q36;p13) and t(7;12)(q32;p13). Five patients with a t(7;12) were from a group of 125 successfully karyotyped pediatric patients enrolled in co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b602310e7c93e3c11afd04c549b8d9b7
https://doi.org/10.1038/sj.leu.2402121

Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization

Autor: Bruce R. Ksander, Dion Paridaens, H. Berna Beverloo, Janneke C. Alers, Rosalyn Slater, Annelies de Klein, Ellen van Drunen, Gregorius P.M. Luyten, Nicole C. Naus

Publikováno v: Genes, Chromosomes and Cancer. 30:267-273

Several nonrandom recurrent chromosomal changes are observed in uveal melanoma. Some of these abnormalities, e.g., loss of chromosome 3, gain of the q arm of chromosome 8, and chromosome 6 abnormalities, are of prognostic value. Cytogenetic analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::937d9880537b27d7452891452445a228
https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1088>3.0.co

In vitro drug resistance and prognostic impact of p16INK4A /P15INK4B deletions in childhood T-cell acute lymphoblastic leukaemia

Autor: Marianne G. Rots, Mats Heyman, Willem Kamps, Rob Pieters, E van Drunen, A H Loonen, H B Beverloo, N. L. Ramakers-Van Woerden, TC Moreno, E. R. Van Wering, G. E. Janka-Schaub, Rosalyn Slater, A. J. P. Veerman

Publikováno v: British Journal of Haematology. 112:680-690

p16 gene deletions are present in about 70% of primary paediatric T-cell acute lymphoblastic leukaemia (T-ALL) and 20% of common/precursor B-cell ALL cases. It is not clear what the impact of the frequent p16 deletions is within the subgroup of T-lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1918a9bea135a73990af8ba275decb3
https://doi.org/10.1046/j.1365-2141.2001.02586.x