Analytical validation of a novel comprehensive genomic profiling informed circulating tumor DNA monitoring assay for solid tumors.

Autor: Daniel R Zollinger, Elizabeth Rivers, Alexander Fine, Yanmei Huang, Joseph Son, Akshita Kalyan, Wren Gray, Golshid Baharian, Carly Hammond, Rosalyn Ram, Lindsay Ringman, Dina Hafez, Daniel Savel, Vipul Patel, Marc Dantone, Cui Guo, Merrida Childress, Chang Xu, Dorhyun Johng, Brett Wallden, Prapti Pokharel, William Camara, Priti S Hegde, Jason Hughes, Corey Carter, Nicole Davarpanah, Viraj Degaonkar, Pratyush Gupta, Sanjeev Mariathasan, Thomas Powles, Sean Ferree, Lucas Dennis, Amanda Young

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0302129 (2024)

Emerging technologies focused on the detection and quantification of circulating tumor DNA (ctDNA) in blood show extensive potential for managing patient treatment decisions, informing risk of recurrence, and predicting response to therapy. Currently

Externí odkaz: https://doaj.org/article/3fc28d0921b64f258d166f8cdf7339fa

Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma

Autor: Ryan Swenerton, Lars Dyrskjøt, Dina Hafez, Zoe June Assaf, Alexey Aleshin, Mads Agerbæk, Samantha Navarro, Hsin-Ta Wu, Claus L. Andersen, Ramya Srinivasan, Emil Christensen, Antony Tin, Scott Dashner, Iver Nordentoft, Mustafa Balcioglu, Jørgen Bjerggaard Jensen, Karin Birkenkamp-Demtröder, Styrmir Sigurjonsson, Michael Knudsen, Sia Viborg Lindskrog, Bernhard Zimmermann, Philippe Lamy, Cheng-Ho Jimmy Lin, Ann Taber, Søren Vang, Alexander Olson, Thomas Reinert, Raheleh Salari, Svetlana Shchegrova, Himanshu Sethi, Shruti Sharma, Rosalyn Ram, Matthew Rabinowitz, Paul Billings

Publikováno v: Christensen, E, Birkenkamp-Demtröder, K, Sethi, H, Shchegrova, S, Salari, R, Nordentoft, I, Wu, H-T, Knudsen, M, Lamy, P, Lindskrog, S V, Taber, A, Balcioglu, M, Vang, S, Assaf, Z, Sharma, S, Tin, A S, Srinivasan, R, Hafez, D, Reinert, T, Navarro, S, Olson, A, Ram, R, Dashner, S, Rabinowitz, M, Billings, P, Sigurjonsson, S, Andersen, C L, Swenerton, R, Aleshin, A, Zimmermann, B, Agerbæk, M, Lin, C-H J, Jensen, J B & Dyrskjøt, L 2019, ' Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma ', Journal of Clinical Oncology, vol. 37, no. 18, pp. 1547-1557 . https://doi.org/10.1200/JCO.18.02052

PURPOSE Novel sensitive methods for early detection of relapse and for monitoring therapeutic efficacy may have a huge impact on risk stratification, treatment, and ultimately outcome for patients with bladder cancer. We addressed the prognostic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc2a7402f41354ed6512f2af9d18c8b
https://pure.au.dk/portal/da/publications/early-detection-of-metastatic-relapse-and-monitoring-of-therapeutic-efficacy-by-ultradeep-sequencing-of-plasma-cellfree-dna-in-patients-with-urothelial-bladder-carcinoma(ae7edf8e-e90c-4709-9f9c-20a1316cbc31).html

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

Autor: Rosalyn Ram, Anthony Orvedahl, Brian O. Bodemann, Yi Hung Ou, Michael A. White, Etienne Formstecher, Charles Yeaman, C. Clayton Hazelett, Jacques Camonis, Eric M. Wauson, Mekhala Maiti, Maria Balakireva, Beth Levine, Tzuling Cheng

Publikováno v: Cell. 144:253-267

SummaryThe study of macroautophagy in mammalian cells has described induction, vesicle nucleation, and membrane elongation complexes as key signaling intermediates driving autophagosome biogenesis. How these components are recruited to nascent autoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc6434d9030412f9ef673583399cc5c
https://doi.org/10.1016/j.cell.2010.12.018

Inhibiting Gene Expression with Locked Nucleic Acids (LNAs) That Target Chromosomal DNA

Autor: David R. Corey, Rosalyn Ram, Brett P. Monia, Sylvie Gabillet, Khalil Arar, Randall L. Beane

Publikováno v: Biochemistry. 46:7572-7580

Oligonucleotides containing locked nucleic acid bases (LNAs) have increased affinity for complementary DNA sequences. We hypothesized that enhanced affinity might allow LNAs to recognize chromosomal DNA inside human cells and inhibit gene expression.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e1b424bdd41887209a808c620f6a4b
https://doi.org/10.1021/bi700227g

Discoidin Domain Receptor-1a (DDR1a) Promotes Glioma Cell Invasion and Adhesion in Association with Matrix Metalloproteinase-2

Autor: Roman Urfer, Karoly Nikolich, Gustavo Lorente, Erik Foehr, Rosalyn Ram, Usha Nagavarapu

Publikováno v: Journal of Neuro-Oncology. 76:239-248

Invasion of glioma cells involves the attachment of invading tumor cells to extracellular matrix (ECM), disruption of ECM components, and subsequent cell penetration into adjacent brain structures. Discoidin domain receptor 1 (DDR1) tyrosine kinases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a4a05b28d20dedeeb2c117f4a62652
https://doi.org/10.1007/s11060-005-6874-1