Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Rosalyn Hithersay"'
Autor:
Carla M. Startin, Hana D’Souza, George Ball, Sarah Hamburg, Rosalyn Hithersay, Kate M. O. Hughes, Esha Massand, Annette Karmiloff-Smith, Michael S. C. Thomas, LonDownS Consortium, Andre Strydom
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-13 (2020)
Abstract Background Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical
Externí odkaz:
https://doaj.org/article/42fed659ef964bd0b3f9ad50702035ff
Autor:
Carla M. Startin, Nicholas J. Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K. Wiseman, Kin Y. Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye, LonDownS Consortium, André Strydom
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer’s disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecula
Externí odkaz:
https://doaj.org/article/8822797bba184f3e9f91696674c7dfa9
Autor:
Carla M. Startin, Bryony Lowe, Sarah Hamburg, Rosalyn Hithersay, Andre Strydom, LonDownS Consortium, Elizabeth Fisher, Dean Nizetic, John Hardy, Victor Tybulewicz, Annette Karmiloff-Smith
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularly for those with more severe intellect
Externí odkaz:
https://doaj.org/article/0df03a1e409e4ad29d4236f3f13e6da8
Autor:
Carla M. Startin, Sarah Hamburg, Rosalyn Hithersay, Amy Davies, Erin Rodger, Nidhi Aggarwal, Tamara Al-Janabi, André Strydom
Publikováno v:
Wellcome Open Research, Vol 1 (2016)
Background: Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing Alzheimer’s disease. However, there is individual variability in the onset of clinical dementia and in bas
Externí odkaz:
https://doaj.org/article/9302829b8cd944928416901c5a7d333a
Autor:
Farah Mgaieth, R. Asaad Baksh, Carla M. Startin, Sarah Hamburg, Rosalyn Hithersay, Sarah Pape, Henrik Zetterberg, Nicholas J. Ashton, Miren Tamayo‐Elizalde, Fedal Saini, Mina Idris, The LonDownS Consortium, Andre Strydom
Publikováno v:
Alzheimer's & Dementia.
Autor:
Shoumitro Shoumi Deb, André Strydom, Rosalyn Hithersay, Tiziano Gomiero, Luc Pieter De Vreese, Matthew P. Janicki, Nancy S. Jokinen, Kathryn P. Service
Publikováno v:
Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder ISBN: 9783319957197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc77332b98ccb7f40276fa0ecc544ebb
https://doi.org/10.1007/978-3-319-95720-3_28
https://doi.org/10.1007/978-3-319-95720-3_28
Autor:
Ana Cindric, Frano Vuckovic, David Koschut, Vincenzo Borelli, Julija Juric, Maja Pucic-Bakovic, Anita Slana, Helena Deris, Azra Frkatović, Aoife Murray, Ivan Alic, Jurgen Groet, Niamh O’Brien, Drazen Petrovic, Sarah Hamburg, Carla Startin, Rosalyn Hithersay, Hana D’Souza, LonDownS Consortium, Tim Spector, Dinko Mitrecic, Mijana Kero, Ljubica Odak, Ingeborg Barisic, Michael Thomas, Andre Strydom, Anne-Sophie Rebillat, Claudio Franceschi, Gordan Lauc, Jasminka Kristic, Dean Nizetic
Cells from people with Down syndrome (DS) show faster accumulation of DNA damage and epigenetic aging marks. Causative mechanisms remain un-proven and hypotheses range from amplified chromosomal instability to actions of several supernumerary chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::548515c2398e5b88c12e6b8f505b6b96
https://doi.org/10.21203/rs.3.rs-1128079/v1
https://doi.org/10.21203/rs.3.rs-1128079/v1
Autor:
Frederick A. Schmitt, Juan Fortea, Donita Lightner, Rosalyn Hithersay, Isabel C. H. Clare, Anne-Sophie Rebillat, Georg Nübling, Laia Muñoz, Alberto Lleó, Shahid Zaman, Kathyrn L Van Pelt, Sarah E Pape, Rafael Blesa, Elizabeth Head, Johannes Levin, Gregory A. Jicha, Daniel Alcolea, Isabel Barroeta, Lisa M. Koehl, Laura Videla, Maria Carmona-Iragui, Andre Strydom, Anthony J. Holland, Clotilde Mircher, Silvia Sacco
Publikováno v:
LANCET NEUROLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
The Lancet. Neurology, vol 20, iss 8
Lancet Neurol
The lancet / Neurology 20(8), 605-614 (2021). doi:10.1016/S1474-4422(21)00129-0
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
The Lancet. Neurology, vol 20, iss 8
Lancet Neurol
The lancet
Summary Background Adults with Down syndrome are at an ultra-high risk of Alzheimer's disease, but diagnosis of Alzheimer's disease in this population is challenging. We aimed to validate the clinical utility of plasma neurofilament light chain (NfL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cf1561c4bfac13058a4fb43ac28108
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5485
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5485
Autor:
Jia Nee Foo, Andre Strydom, Xiaowei Shao, David Koschut, Goran Šimić, Željka Krsnik, Sarah Hamburg, Ivan Alić, Steven Havlicek, Hlin Kvartsberg, Jürgen Groet, Paul T. Francis, Yee Jie Yeap, Pollyanna Goh, Hilkka Soininen, Rosalyn Hithersay, John Hardy, Niamh L. O'Brien, Margaret Phillips, David Laurence Becker, N. Ray Dunn, Gunnar Brinkmalm, David Wallon, Gillian Gough, Henrik Zetterberg, Erik Portelius, Mark Turmaine, Aoife Murray, Jorge Ghiso, Kaj Blennow, Eleni Gkanatsiou, Agueda Rostagno, Carla M. Startin, Ivica Kostović, Konstantin Pervushin, Emanuela V. Volpi, Dean Nižetić, Joanne E. Martin, Dinko Mitrečić, Reinhard Brunmeir, Kin Y. Mok, Anne Rovelet-Lecrux
Publikováno v:
Molecular Psychiatry
A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09de58af74b7f90b471059b4fee6daab
https://doi.org/10.1038/s41380-020-0806-5
https://doi.org/10.1038/s41380-020-0806-5
Autor:
Ben Carter, Daniel C. Alexander, Andrew J. Aschenbrenner, Jason Hassenstab, Judith Jaeger, P. A. Wijeratne, Rosalyn Hithersay, Asaad Baksh, Andre Strydom
Publikováno v:
Alzheimer's & Dementia. 16