Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rosalinda Syto"'
Autor:
Joseph E. Myers, Zhizhang Yin, Ahmed A. Samatar, William T. Windsor, Rosalinda Syto, Zhuomei Lu, Sandra Koseoglu, C. Chandra Kumar, Paul Kirschmeier, Todd Mayhood, Jill M. Stafford, Tammy C. Turek-Etienne, Linda James, Bruce A. Malcolm
Publikováno v:
SLAS Discovery. 9:309-321
Most of the protein kinase inhibitors being developed are directed toward the adenosine triphosphate (ATP) binding site that is highly conserved in many kinases. A major issue with these inhibitors is the specificity for a given kinase. Structure det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46773bef802fc568f62c01c68ef19547
https://doi.org/10.1177/1087057104263506
https://doi.org/10.1177/1087057104263506
Autor:
Eric Huang, Nicholas J. Murgolo, Philip Mui, Rosalinda Syto, William T Windsor, Emory H. Braswell
Publikováno v:
Biochemistry. 37:16943-16951
Human interleukin 10 (huIL-10) is a cytokine that regulates the synthesis of type 1 helper T cell derived cytokines such as gamma-interferon, interleukin 2, and tumor necrosis factor alpha. The potential immunosuppressive activities of huIL-10 sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc06791ebf866fefebfc33dce376e95
https://doi.org/10.1021/bi981555y
https://doi.org/10.1021/bi981555y
Autor:
Jeffrey Schwartz, Patricia C. Weber, Rosalinda Syto, Zhen Wu, Lorena S. Beese, William T. Windsor, Corey Strickland, Hung V. Le, Lynn Wang, Richard Bond
Publikováno v:
Biochemistry. 37:16601-16611
The crystallographic structure of acetyl-Cys-Val-Ile-selenoMet-COOH and alpha-hydroxyfarnesylphosphonic acid (alphaHFP) complexed with rat farnesyl protein transferase (FPT) (space group P61, a = b = 174. 13 A, c = 69.71 A, alpha = beta = 90 degrees,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7062759ac68b2416257f97a28d2ab8
https://doi.org/10.1021/bi981197z
https://doi.org/10.1021/bi981197z
Autor:
Lianyun Zhao, Patrick J. Curran, Paul Kirschmeier, Rosalinda Syto, Yongqi Deng, Jose S. Duca, Alan Hruza, Gerald W. Shipps, William T. Windsor, Thierry O. Fischmann, David A. Parry, Vincent S. Madison, Emma Lees, Rumin Zhang, M. Arshad Siddiqui, Charles Wayne Mcnemar, Allen Annis, Janeta Popovici-Muller, Todd Mayhood
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(1)
A new class of quinoline-based kinase inhibitors has been discovered that both disrupt cyclin dependent 2 (CDK2) interaction with its cyclin A subunit and act as ATP competitive inhibitors. The key strategy for discovering this class of protein-prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77b9c772265e004481c9e592efc212b
https://pubmed.ncbi.nlm.nih.gov/24332088
https://pubmed.ncbi.nlm.nih.gov/24332088
Autor:
Tattanahalli L. Nagabhushan, Rosalinda Syto, Mark R. Walter, William J. Cook, William T. Windsor, James Fossetta, Leigh J Walter
Publikováno v:
Proteins: Structure, Function, and Genetics. 26:108-114
X-ray diffraction quality crystals have been obtained from a complex between interferon gamma and the extracellular domain of its high-affinity cell surface receptor. The crystals were obtained from interferon gamma/interferon gamma receptor complexe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7460176cf3c00a8ce4c906d7b5270965
https://doi.org/10.1002/(sici)1097-0134(199609)26:1<108::aid-prot10>3.0.co
https://doi.org/10.1002/(sici)1097-0134(199609)26:1<108::aid-prot10>3.0.co
Autor:
W. Robert Bishop, Richard Bond, Joanne Petrin, Lynn Wang, Robert Patton, Ronald Doll, George Njoroge, Joseph Catino, Jerome Schwartz, William Windsor, Rosalinda Syto, Jeffrey Schwartz, Donna Carr, Linda James, Paul Kirschmeier
Publikováno v:
Journal of Biological Chemistry. 270:30611-30618
Ras protooncogenes encode 21-kDa membrane-associated guanine nucleotide-binding proteins, which play a critical role in control of cellular proliferation and differentiation. Oncogenic, activated forms of Ras proteins are associated with a broad rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806a08d9f0869dc2099b18a7e9b9d4b1
https://doi.org/10.1074/jbc.270.51.30611
https://doi.org/10.1074/jbc.270.51.30611
Autor:
Birendra N. Pramanik, James Durkin, Philip W. Mui, Paul P. Trotta, William T. Windsor, Rumin Zhang, Anthony Tsarbopoulos, Paliwal S, Rosalinda Syto, Samuel Baldwin
Publikováno v:
Biochemistry. 32:8807-8815
Interleukin 10 (IL-10), which was first discovered by its ability to inhibit the synthesis of various cytokines, most notably gamma interferon, from Th1 helper cells, displays pleiotropic immunoregulatory properties. Human and murine IL-10 have a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c220ca6b2d0caf84f678e9f5878b8f08
https://doi.org/10.1021/bi00085a011
https://doi.org/10.1021/bi00085a011
Autor:
Gail F. Seelig, Doreen Borkowski, William T. Windsor, Hung V. Le, Rosalinda Syto, Paul P. Trotta, Lata Ramanathan
Publikováno v:
Biochemistry. 30:9576-9582
Human interleukin 4 is a 129 amino acid lymphokine secreted by activated T cells that exerts pleiotropic biological effects on B and T lymphocytes and other hematopoietic cells. Structure-function relations were studied by employing selective proteol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9eb9767c4bc9d3a53ce86892fc11b5f
https://doi.org/10.1021/bi00104a003
https://doi.org/10.1021/bi00104a003
Autor:
Rumin, Zhang, Todd, Mayhood, Philip, Lipari, Yaolin, Wang, James, Durkin, Rosalinda, Syto, Jennifer, Gesell, Charles, McNemar, William, Windsor
Publikováno v:
Analytical biochemistry. 331(1)
MDM2 is an important negative regulator of the tumor suppressor protein p53 which regulates the expression of many genes including MDM2. The delicate balance of this autoregulatory loop is crucial for the maintenance of the genome and control of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4bb9770f486cfb6340f99eeeaaa91b0
https://pubmed.ncbi.nlm.nih.gov/15246006
https://pubmed.ncbi.nlm.nih.gov/15246006
Autor:
Hung V. Le, Rosalinda Syto, Mark Demma, Zhen Wu, William T. Windsor, Corey Strickland, Patricia C. Weber
Publikováno v:
Protein engineering. 12(4)
Protein farnesyltransferase (FPT) is a 97 000 Da heterodimeric enzyme that catalyzes post-translational farnesylation of many cellular regulatory proteins including p21 Ras. To facilitate the construction of site-directed mutants, a novel translation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903f4ab8262061517a6b7ea5aa34886c
https://pubmed.ncbi.nlm.nih.gov/10325405
https://pubmed.ncbi.nlm.nih.gov/10325405