ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

Autor: Maria Kalyuga, David Gallego-Ortega, Heather J Lee, Daniel L Roden, Mark J Cowley, C Elizabeth Caldon, Andrew Stone, Stephanie L Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L Statham, Nicola Armstrong, M Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L Piggin, Cara J Evans, Anita Ledger, Tilman Brummer, Samantha R Oakes, Warren Kaplan, Julia M W Gee, Robert I Nicholson, Robert L Sutherland, Alexander Swarbrick, Matthew J Naylor, Susan J Clark, Jason S Carroll, Christopher J Ormandy

Publikováno v: PLoS Biology, Vol 10, Iss 12, p e1001461 (2012)

We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage, raising the possibilit

Externí odkaz: https://doaj.org/article/7e94d3be63174fc88be2581b9f7d3521

Cell cycle-coupled expansion of AR activity promotes cancer progression

Autor: Michael A. Augello, Alfonso Urbanucci, Jonathan F. Goodwin, Clay E.S. Comstock, Jason S. Carroll, Karen E. Knudsen, Christopher McNair, Felix Y. Feng, Jeffrey Karnes, Wei Li, Adam Ertel, Ian G. Mills, Matthew J. Schiewer, Qianben Wang, Rosalind Launchbury, Shuang G. Zhao, Liguo Wang, E. Davicioni

Publikováno v: Oncogene
Oncogene, vol 36, iss 12
McNair, C, Urbanucci, A, Comstock, C E S, Augello, M A, Goodwin, J F, Launchbury, R, Zhao, S G, Schiewer, M J, Ertel, A, Karnes, J, Davicioni, E, Wang, L, Wang, Q, Mills, I G, Feng, F Y, Li, W, Carroll, J S & Knudsen, K E 2016, ' Cell cycle-coupled expansion of AR activity promotes cancer progression ', Oncogene, vol. 36, pp. 1655–1668 . https://doi.org/10.1038/onc.2016.334

The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic intervention for disseminated disease. While initially effective, recurrent tumors ultimately aris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908f9012a84dcaa655f9d85c953d5c84
https://pubmed.ncbi.nlm.nih.gov/27669432

Expression of theforkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the Androgen receptor in prostate cancer but is not directly regulated by Androgens or hypoxia

Autor: Stephen B. Fox, Peter Malone, Alison H. Banham, Adrian L. Harris, Jane L. Boddy, Rosalind Launchbury, Cheng Han, Helen Turley

Publikováno v: The Prostate. 67:1091-1098

BACKGROUND FOXP1 is a member of the winged helix or forkhead transcription factors. Recent studies have indicated possible roles for FOXP1 as a candidate tumor suppressor gene and a potential estrogen receptor (ER) co-regulator in the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90b1a9f9785c68030a29cf5cbe45b9e
https://doi.org/10.1002/pros.20583

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer

Autor: Nicola J. Armstrong, Anita Ledger, Catherine L. Piggin, Christopher J. Ormandy, Maria Kalyuga, Matthew J. Naylor, Alexander Swarbrick, Jason S. Carroll, Adelaide Young, Cara J. Evans, Daniel L. Roden, Aaron L. Statham, C. Elizabeth Caldon, David Gallego-Ortega, M. Chehani Alles, Heather J. Lee, Tilman Brummer, Mark J. Cowley, Stephanie L. Allerdice, Fatima Valdes-Mora, Susan J. Clark, Warren Kaplan, Julia Margaret Wendy Gee, Robert L. Sutherland, Andrea Egger, Robert Ian Nicholson, Rosalind Launchbury, Wendy Wing Yee Au, Samantha R. Oakes, Andrew Stone

Publikováno v: PLoS Biology, Vol 10, Iss 12, p e1001461 (2012)
PLoS Biology

The transcription factor ELF5 is responsible for gene expression patterning underlying molecular subtypes of breast cancer and may mediate acquired resistance to anti-estrogen therapy.
We have previously shown that during pregnancy the E-twenty-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b3f2b7fe954e81ba0a1ae6db69f8e8
https://www.repository.cam.ac.uk/handle/1810/316297

Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells

Autor: Alison H. Banham, Rosalind Launchbury, Philip J. Brown, Linden Lyne, Giovanna Roncador, Paola A. Bignone, Kevin C. Gatter, Rajko Kusec, Andrew J. Campbell, Charles H. Lawrie, Jianxiang Chi

FOXP2 mutation causes a severe inherited speech and language defect, while the related transcription factors FOXP1, FOXP3 and FOXP4 are implicated in cancer. FOXP2 mRNA and protein expression were characterised in normal human tissues, haematological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad121cc8a4979bf47abcd79cb82ff656
https://www.bib.irb.hr/541485