Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rosalind H. Gunby"'
Autor:
Brenda J. Green, Margherita Marazzini, Ben Hershey, Amir Fardin, Qingsen Li, Zongjie Wang, Giovanni Giangreco, Federica Pisati, Stefano Marchesi, Andrea Disanza, Emanuela Frittoli, Emanuele Martini, Serena Magni, Galina V. Beznoussenko, Claudio Vernieri, Riccardo Lobefaro, Dario Parazzoli, Paolo Maiuri, Kristina Havas, Mahmoud Labib, Sara Sigismund, Pier Paolo Di Fiore, Rosalind H. Gunby, Shana O. Kelley, Giorgio Scita
Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and worse patient prognosis, but are rare, difficult to count, and poorly characterized biophysically. The PillarX device described here is a bimodular microflui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2318fd58a68238b3bd0604f6facc47c9
http://hdl.handle.net/11588/888266
http://hdl.handle.net/11588/888266
Autor:
Miriam Puttini, Sara Redaelli, Loris Moretti, Stefania Brussolo, Rosalind H Gunby, Luca Mologni, Edoardo Marchesi, Loredana Cleris, Arianna Donella-Deana, Peter Drueckes, Elisa Sala, Vittorio Lucchini, Michael Kubbutat, Franca Formelli, Alfonso Zambon, Leonardo Scapozza, Carlo Gambacorti-Passerini
Publikováno v:
Haematologica, Vol 93, Iss 5 (2008)
Background Resistance to imatinib is an important clinical issue in the treatment of Philadelphia chromosome-positive leukemias which is being tackled by the development of new, more potent drugs, such as the dual Src/Abl tyrosine kinase inhibitors d
Externí odkaz:
https://doaj.org/article/839b4747051b44098bb581c8fc4ef65c
Autor:
Elisa Sala, Alfonso Zambon, Stefania Brussolo, Luca Mologni, Vittorio Lucchini, Edoardo Marchesi, Loredana Cleris, Loris Moretti, Sara Redaelli, Arianna Donella-Deana, Franca Formelli, Carlo Gambacorti-Passerini, Peter Drueckes, Rosalind H. Gunby, Miriam Puttini, Michael H.G. Kubbutat, Leonardo Scapozza
Publikováno v:
Haematologica. 93:653-661
Background: Resistance to imatinib is an important clinical issue in the treatment of Philadelphia chromosomepositive leukemias which is being tackled by the development of new, more potent drugs, such as the dual Src/Abl tyrosine kinase inhibitors d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9525d81ad7c26c3b1b728c42615763
https://doi.org/10.3324/haematol.12212
https://doi.org/10.3324/haematol.12212
Autor:
Lorenzo A. Pinna, Barbara Cimbro, Roberta Sottocornola, Addolorata M. L. Coluccia, Arianna Donella-Deana, Carlo Gambacorti-Passerini, Rosalind H. Gunby, Carmen J Tartari, Leonardo Scapozza
Publikováno v:
Journal of Biological Chemistry. 283:3743-3750
NPM/ALK is an oncogenic fusion protein expressed in approximately 50% of anaplastic large cell lymphoma cases. It derives from the t(2;5)(p23;q35) chromosomal translocation that fuses the catalytic domain of the tyrosine kinase, anaplastic lymphoma k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d2effa24ffd15078f954af39ca2f1d
https://doi.org/10.1074/jbc.m706067200
https://doi.org/10.1074/jbc.m706067200
Autor:
Luca Mologni, Carlo Gambacorti-Passerini, Rosalind H. Gunby, Elisa Sala, Carmen J Tartari, Miriam Puttini
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 7:594-611
Deregulated activation of protein tyrosine kinases (PTKs) is a frequent event underlying malignant transformation in many types of cancer. The formation of oncogenic fusion tyrosine kinases (FTKs) resulting from genomic rearrangements, represents a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3361d6cf4447d2bb0389063f8bbce4c4
https://doi.org/10.2174/187152007784111340
https://doi.org/10.2174/187152007784111340
Autor:
Leonardo Scapozza, Sara Redaelli, Shaheen Ahmed, Rosalind H. Gunby, Carlo Gambacorti-Passerini, Luca Mologni, Marc Gasser, Valentina Belloni, Carmen J Tartari, Roberta Sottocornola
Publikováno v:
Journal of Medicinal Chemistry. 49:5759-5768
Anaplastic lymphoma kinase (ALK) is a valid target for anticancer therapy; however, potent ALK inhibitors suitable for clinical use are lacking. Because the majority of described kinase inhibitors bind in the ATP pocket of the kinase domain, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a2874beb05a64521ade2526b1ded88
https://doi.org/10.1021/jm060380k
https://doi.org/10.1021/jm060380k
Autor:
Carmen J. Tartari, A Ml Coluccia, Leonardo Scapozza, Lorena Passoni, Carlo Gambacorti-Passerini, Rosalind H. Gunby
Publikováno v:
Expert Opinion on Therapeutic Targets. 9:515-532
A crucial issue in the development of molecularly-targeted anticancer therapies is the identification of appropriate molecules whose targeting would result in tumour regression with a minimal level of systemic toxicity. Anaplastic lymphoma kinase (AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d38fda766bd98d29278b1bc0417ee38
https://doi.org/10.1517/14728222.9.3.515
https://doi.org/10.1517/14728222.9.3.515
Autor:
Silvia Perego, Lorena Passoni, Rosalind H. Gunby, Loredana Cleris, Edoardo Marchesi, Addolorata Coluccia, Carlo Gambacorti-Passerini, Franca Formelli
Publikováno v:
Blood. 103:2787-2794
Deregulated apoptosis is a common finding in tumorigenesis. The oncogenic tyrosine kinase nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) delivers a strong survival signal in anaplastic large cell lymphomas (ALCLs). Although NPM/ALK activates mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d6db568e399f0e9ad1eb203d94abc9
https://doi.org/10.1182/blood-2003-09-3144
https://doi.org/10.1182/blood-2003-09-3144
Autor:
Clare L Brunet, John A. Hickman, Gerard Brady, Alastair J.M. Watson, Roderick Sp Benson, Rosalind H Gunby
Publikováno v:
Cell Death & Differentiation. 5:107-115
Kinetic analysis of dexamethasone-induced apoptosis in the human lymphoblastoid cell line CCRF CEM C7A has revealed a point when cells, morphologically indistinguishable from untreated cells, have irreversibly engaged a program leading to death, meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2c5b3c72e6406789a8f71cbfdbc947
https://doi.org/10.1038/sj.cdd.4400334
https://doi.org/10.1038/sj.cdd.4400334
Publikováno v:
Cellular Immunology. 177:119-128
Signals transduced through CD40 rescue cells of the Ramos–Burkitt lymphoma (Ramos-BL) B cell line from surface immunoglobulin M (sIgM)-triggered growth arrest and apoptosis. This study investigates whether protein tyrosine kinase (PTK) activity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345489e61477851d2da2369ec0bb0d13
https://doi.org/10.1006/cimm.1997.1102
https://doi.org/10.1006/cimm.1997.1102