Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Rosalind A. Segal"'
Autor:
Robert Knoerl, Emanuele Mazzola, Maria Pazyra-Murphy, Birgitta Ryback, A. Lindsay Frazier, Roy L. Freeman, Marilyn Hammer, Ann LaCasce, Jennifer Ligibel, Marlise R. Luskin, Donna L. Berry, Rosalind A. Segal
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Approximately 70% of patients receiving neurotoxic chemotherapy (e.g., paclitaxel or vincristine) will develop chemotherapy-induced peripheral neuropathy. Despite the known negative effects of CIPN on physical functioning and chem
Externí odkaz:
https://doaj.org/article/882870651fc5420692d96a30907b0cad
Autor:
Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E. Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A. Segal, Ghazaleh Tabatabai, Daniel J. Merk
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising clinical efficacy. Yet, primary
Externí odkaz:
https://doaj.org/article/1081383d8a884e1bb850b117fd782524
Autor:
Maxwell P. Gold, Winnie Ong, Andrew M. Masteller, David R. Ghasemi, Julie Anne Galindo, Noel R. Park, Nhan C. Huynh, Aneesh Donde, Veronika Pister, Raul A. Saurez, Maria C. Vladoiu, Grace H. Hwang, Tanja Eisemann, Laura K. Donovan, Adam D. Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A. Segal, Robert J. Wechsler-Reya, Jill P. Mesirov, Andrey Korshunov, Kristian W. Pajtler, Scott L. Pomeroy, Olivier Ayrault, Shawn M. Davidson, Jennifer A. Cotter, Michael D. Taylor, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hed
Externí odkaz:
https://doaj.org/article/7e7b389f322c4aed99ee994b5589418d
Autor:
Zachary J. Reitman, Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, Hayley Malkin, Ying Huang, Leslie Grimmet, Zachary T. Herbert, Yu Sun, Jessica L. Weatherbee, John A. Alberta, John F. Daley, Orit Rozenblatt-Rosen, Alexandra L. Condurat, Kenin Qian, Prasidda Khadka, Rosalind A. Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles D. Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
Externí odkaz:
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd
Autor:
Martin Balastik, Xiao Zhen Zhou, Meritxell Alberich-Jorda, Romana Weissova, Jakub Žiak, Maria F. Pazyra-Murphy, Katharina E. Cosker, Olga Machonova, Iryna Kozmikova, Chun-Hau Chen, Lucia Pastorino, John M. Asara, Adam Cole, Calum Sutherland, Rosalind A. Segal, Kun Ping Lu
Publikováno v:
Cell Reports, Vol 13, Iss 4, Pp 812-828 (2015)
Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood. Here, we show tha
Externí odkaz:
https://doaj.org/article/59143a7db6614643bea7b694861dcc5e
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and enduring disorder caused by several
Externí odkaz:
https://doaj.org/article/a69d0abdcb644feb9e2a08d5078f9a6a
Autor:
Rosalind A. Segal, Joseph F. Kelleher, Tatyana Ponomaryov, Emily J. Chadwick, Ethan L. MacKenzie, Maria F. Pazyra-Murphy, Kimberly J. Ornell, Ekaterina Pak, Xuesong Zhao
Supplementary Table S1, related to Figure 1. A total of 182 transposon insertions were identified in 27 resistant clones. Provided as a separate Excel file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eacc9f91fb2aeaeaa86fd6a8f08293d
https://doi.org/10.1158/2159-8290.22532324.v1
https://doi.org/10.1158/2159-8290.22532324.v1
Autor:
Rosalind A. Segal, Joseph F. Kelleher, Tatyana Ponomaryov, Emily J. Chadwick, Ethan L. MacKenzie, Maria F. Pazyra-Murphy, Kimberly J. Ornell, Ekaterina Pak, Xuesong Zhao
Supplementary Figures, tables, methods and references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347466695fdd9ed9aa10fffc6f1662e5
https://doi.org/10.1158/2159-8290.22532327
https://doi.org/10.1158/2159-8290.22532327
Autor:
Rosalind A. Segal, Joseph F. Kelleher, Jennifer A. Chan, Anthony E. Oro, Jiang Li, Anne Lynn S. Chang, Ramon J. Whitson, Scott X. Atwood, Wei Li, Ekaterina Pak, Sukriti K. Dabral, Pengcheng Zhou, Kimberly J. Ornell, Tatyana Ponomaryov, Xuesong Zhao
Figure S1. Growth and survival of SMB cells depends on Shh signaling. Figure S2. SMB cell lines are a faithful model to study resistance to Smo inhibitors. Table S1. List of candidate genes with mutations used in the study. Figure S3. RAS signaling c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21638a36bfc043d8a55849f45c1b2420
https://doi.org/10.1158/0008-5472.22405127
https://doi.org/10.1158/0008-5472.22405127
Autor:
Liat Peretz Zats, Labiba Ahmad, Natania Casden, Meelim J Lee, Vitali Belzer, Orit Adato, Shaked Bar Cohen, Seung-Hyun B Ko, Mariella G Filbin, Ron Unger, Douglas A Lauffenburger, Rosalind A Segal, Oded Behar
Publikováno v:
Neuro-oncology advances. 4(1)
Background High-grade gliomas (HGG) in children have a devastating prognosis and occur in a remarkable spatiotemporal pattern. Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), typically occur in mid-childhood, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba718869e031615ce89e2d097f37d48a
https://pubmed.ncbi.nlm.nih.gov/35990702
https://pubmed.ncbi.nlm.nih.gov/35990702