Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Rosalind A Segal"'
Autor:
Robert Knoerl, Emanuele Mazzola, Maria Pazyra-Murphy, Birgitta Ryback, A. Lindsay Frazier, Roy L. Freeman, Marilyn Hammer, Ann LaCasce, Jennifer Ligibel, Marlise R. Luskin, Donna L. Berry, Rosalind A. Segal
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Approximately 70% of patients receiving neurotoxic chemotherapy (e.g., paclitaxel or vincristine) will develop chemotherapy-induced peripheral neuropathy. Despite the known negative effects of CIPN on physical functioning and chem
Externí odkaz:
https://doaj.org/article/882870651fc5420692d96a30907b0cad
Autor:
Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E. Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A. Segal, Ghazaleh Tabatabai, Daniel J. Merk
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising clinical efficacy. Yet, primary
Externí odkaz:
https://doaj.org/article/1081383d8a884e1bb850b117fd782524
Autor:
Maxwell P. Gold, Winnie Ong, Andrew M. Masteller, David R. Ghasemi, Julie Anne Galindo, Noel R. Park, Nhan C. Huynh, Aneesh Donde, Veronika Pister, Raul A. Saurez, Maria C. Vladoiu, Grace H. Hwang, Tanja Eisemann, Laura K. Donovan, Adam D. Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A. Segal, Robert J. Wechsler-Reya, Jill P. Mesirov, Andrey Korshunov, Kristian W. Pajtler, Scott L. Pomeroy, Olivier Ayrault, Shawn M. Davidson, Jennifer A. Cotter, Michael D. Taylor, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hed
Externí odkaz:
https://doaj.org/article/7e7b389f322c4aed99ee994b5589418d
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16753 (2011)
Disruptions in axonal transport have been implicated in a wide range of neurodegenerative diseases. Cramping 1 (Cra1/+) and Legs at odd angles (Loa/+) mice, with hypomorphic mutations in the dynein heavy chain 1 gene, which encodes the ATPase of the
Externí odkaz:
https://doaj.org/article/abbbc5293cf645a0ae11be11ed4deecf
Autor:
Rosalind A. Segal, Joseph F. Kelleher, Tatyana Ponomaryov, Emily J. Chadwick, Ethan L. MacKenzie, Maria F. Pazyra-Murphy, Kimberly J. Ornell, Ekaterina Pak, Xuesong Zhao
Supplementary Table S1, related to Figure 1. A total of 182 transposon insertions were identified in 27 resistant clones. Provided as a separate Excel file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eacc9f91fb2aeaeaa86fd6a8f08293d
https://doi.org/10.1158/2159-8290.22532324.v1
https://doi.org/10.1158/2159-8290.22532324.v1
Autor:
Rosalind A. Segal, Joseph F. Kelleher, Tatyana Ponomaryov, Emily J. Chadwick, Ethan L. MacKenzie, Maria F. Pazyra-Murphy, Kimberly J. Ornell, Ekaterina Pak, Xuesong Zhao
Supplementary Figures, tables, methods and references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347466695fdd9ed9aa10fffc6f1662e5
https://doi.org/10.1158/2159-8290.22532327
https://doi.org/10.1158/2159-8290.22532327
Autor:
Rosalind A. Segal, Joseph F. Kelleher, Jennifer A. Chan, Anthony E. Oro, Jiang Li, Anne Lynn S. Chang, Ramon J. Whitson, Scott X. Atwood, Wei Li, Ekaterina Pak, Sukriti K. Dabral, Pengcheng Zhou, Kimberly J. Ornell, Tatyana Ponomaryov, Xuesong Zhao
Figure S1. Growth and survival of SMB cells depends on Shh signaling. Figure S2. SMB cell lines are a faithful model to study resistance to Smo inhibitors. Table S1. List of candidate genes with mutations used in the study. Figure S3. RAS signaling c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21638a36bfc043d8a55849f45c1b2420
https://doi.org/10.1158/0008-5472.22405127
https://doi.org/10.1158/0008-5472.22405127
Autor:
Martin Balastik, Xiao Zhen Zhou, Meritxell Alberich-Jorda, Romana Weissova, Jakub Žiak, Maria F. Pazyra-Murphy, Katharina E. Cosker, Olga Machonova, Iryna Kozmikova, Chun-Hau Chen, Lucia Pastorino, John M. Asara, Adam Cole, Calum Sutherland, Rosalind A. Segal, Kun Ping Lu
Publikováno v:
Cell Reports, Vol 13, Iss 4, Pp 812-828 (2015)
Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood. Here, we show tha
Externí odkaz:
https://doaj.org/article/59143a7db6614643bea7b694861dcc5e
Autor:
Liat Peretz Zats, Labiba Ahmad, Natania Casden, Meelim J Lee, Vitali Belzer, Orit Adato, Shaked Bar Cohen, Seung-Hyun B Ko, Mariella G Filbin, Ron Unger, Douglas A Lauffenburger, Rosalind A Segal, Oded Behar
Publikováno v:
Neuro-oncology advances. 4(1)
Background High-grade gliomas (HGG) in children have a devastating prognosis and occur in a remarkable spatiotemporal pattern. Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), typically occur in mid-childhood, while
Autor:
Christopher M Rota, Alexander T Brown, Emily Addleson, Clara Ives, Ella Trumper, Kristine Pelton, Wei Pin Teh, Matthew J Schniederjan, Robert Craig Castellino, Sara Buhrlage, Douglas A Lauffenburger, Keith L Ligon, Linda G Griffith, Rosalind A Segal
Publikováno v:
Neurooncol Adv
Background Pediatric gliomas comprise a diverse set of brain tumor entities that have substantial long-term ramifications for patient survival and quality of life. However, the study of these tumors is currently limited due to a lack of authentic mod