Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

Autor: Rosalieke E. Wiegel, Maud J. H. Karsten, Igna F. Reijnders, Lenie van Rossem, Sten P. Willemsen, Annemarie G. M. G. J. Mulders, Anton H. J. Koning, Eric A. P. Steegers, A. H. Jan Danser, Régine P. M. Steegers-Theunissen

Publikováno v: Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-14 (2021)

Abstract Background Pregnancies with > 1 corpus luteum (CL) display a hyperdynamic circulation and an increased risk of small-for-gestational age deliveries. Among the factors released by the CL is prorenin, the inactive precursor of renin. Since the

Externí odkaz: https://doaj.org/article/c9fbac1508ef4a978924c2a1345033b7

Circulating maternal prorenin and oocyte and preimplantation embryo development: the Rotterdam Periconception Cohort

Autor: Rosalieke E Wiegel, A H Jan Danser, Linette van Duijn, Sten P Willemsen, Joop S E Laven, Eric A P Steegers, Esther B Baart, Régine P M Steegers-Theunissen

Publikováno v: Human reproduction (Oxford, England), 38(4), 582-595. Oxford University Press

STUDY QUESTION Could circulating maternal prorenin serve as a proxy for oocyte and preimplantation embryo development, assessed by time-lapse parameters and clinical treatment outcomes? SUMMARY ANSWER High circulating maternal prorenin concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286827e6b79b50ad7cfea4f438d502e6
https://pure.eur.nl/en/publications/08ace5a1-3f79-4539-8fcf-9fe25fd9bf54

Shorter periconception maternal telomere length and the risk of congenital cardiac outflow defects in the offspring

Autor: Damiat Aoulad Fares, Rosalieke E. Wiegel, Alex J. Eggink, Sten P. Willemsen, Joyce B. J. van Meurs, Régine P. M. Steegers‐Theunissen

Publikováno v: European Journal of Clinical Investigation, 52(8):e13784. Wiley-Blackwell Publishing Ltd

Background: Congenital cardiac outflow defects (COD) are the largest group of congenital heart defects, with ventricular septal defect (VSD) as the most prevalent phenotype. Increased maternal age, excessive oxidative stress and inflammation are invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a724b9ac5404cceaab513dc40272c31
https://doi.org/10.1111/eci.13784

Polycystic ovary syndrome

Autor: Joop S.E. Laven, Kevin D. Sinclair, Rosalieke E. Wiegel, Pauline W. Jansen, Régine P.M. Steegers-Theunissen

Publikováno v: International Journal of Molecular Sciences, 21(21):8211, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8211, p 8211 (2020)

Polycystic ovary syndrome (PCOS) is an endocrine condition associated with reproductive and psychiatric disorders, and with obesity. Eating disorders, such as bulimia and recurrent dieting, are also linked to PCOS. They can lead to the epigenetic dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b45151eadb0a9bdd376edfec962a03
http://www.scopus.com/inward/record.url?scp=85095731732&partnerID=8YFLogxK

Prorenin periconceptionally and in pregnancy: Does it have a physiological role?

Autor: A.H. Jan Danser, Eric A.P. Steegers, Régine P.M. Steegers-Theunissen, Rosalieke E. Wiegel, Frauke von Versen-Höynck

Publikováno v: Molecular and Cellular Endocrinology, 522:111118. Elsevier Ireland Ltd

Pregnancy demands major cardiovascular, renal and endocrine changes to provide an adequate blood supply for the growing fetus. The renin-angiotensin-aldosterone system plays a key role in this adaptation process. One of its components, prorenin, is r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c390eb3c6aa7fc7f6838f8f888f00eb
https://pubmed.ncbi.nlm.nih.gov/33340569