A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences

Autor: Carolin Huber, Rosalie Nijssen, Hans Mol, Jean Philippe Antignac, Martin Krauss, Werner Brack, Kevin Wagner, Laurent Debrauwer, Chiara Maria Vitale, Elliott James Price, Jana Klanova, Borja Garlito Molina, Nuria Leon, Olga Pardo, Sandra F. Fernández, Tamás Szigeti, Szilvia Középesy, Libor Šulc, Pavel Čupr, Inese Mārtiņsone, Läsma Akülova, Ilse Ottenbros, Roel Vermeulen, Jelle Vlaanderen, Mirjam Luijten, Arjen Lommen

Publikováno v: Environment International, Vol 168, Iss , Pp 107452- (2022)

Within the Human Biomonitoring for Europe initiative (HBM4EU), a study to determine new biomarkers of exposure to pesticides and to assess exposure patterns was conducted. Human urine samples (N = 2,088) were collected from five European regions in t

Externí odkaz: https://doaj.org/article/172d1a122781414199e9eaf3ca396f8f

Aflatoxin B1 Metabolism of Reared Alphitobius diaperinus in Different Life-Stages

Autor: Nathan Meijer, Rosalie Nijssen, Marlou Bosch, Ed Boers, H. J. van der Fels-Klerx

Publikováno v: Insects, Vol 13, Iss 4, p 357 (2022)

The presence of carcinogenic aflatoxins in food and feed is a major issue. In prior studies, aflatoxin B1 (AfB1) and known primary metabolites were absent from Lesser Mealworm (LMW, Alphitobius diaperinus) reared on contaminated diets. LMW is a promi

Externí odkaz: https://doaj.org/article/14b1e21110f440309c4e7c9235472475

Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells

Autor: Meike van der Zande, Jochem Louisse, Deborah Rijkers, Ad A. C. M. Peijnenburg, Aafke W. F. Janssen, Loes P. M. Duivenvoorde, Rosalie Nijssen

Publikováno v: Archives of Toxicology
Archives of Toxicology, 95(3), 907-922
Archives of Toxicology 95 (2021) 3

Human intestinal organoids (HIOs) are a promising in vitro model consisting of different intestinal cell types with a 3D microarchitecture resembling native tissue. In the current study, we aimed to assess the expression of the most common intestinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f5916b0efacb2ef9dacccab4a7ee00
http://europepmc.org/articles/PMC7904554

Harmonized Quality Assurance/Quality Control Provisions for Nontargeted Measurement of Urinary Pesticide Biomarkers in the HBM4EU Multisite SPECIMEn Study

Autor: Chiara Maria Vitale, Arjen Lommen, Carolin Huber, Kevin Wagner, Borja Garlito Molina, Rosalie Nijssen, Elliott James Price, Marco Blokland, Frederike van Tricht, Hans G. J. Mol, Martin Krauss, Laurent Debrauwer, Olga Pardo, Nuria Leon, Jana Klanova, Jean-Philippe Antignac

Publikováno v: Analytical Chemistry, 94, 7833-7843
Analytical Chemistry 94 (2022)
Analytical Chemistry

A set of quality assurance/quality control (QA/QC) criteria for nontargeted measurement of pesticide exposure markers in a large-scale study of human urine has been proposed and applied across five laboratories within the HBM4EU project. Quality cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4731e15d386878afb8df6fc9933bacd1
https://research.wur.nl/en/publications/harmonized-quality-assurancequality-control-provisions-for-nontar

Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS

Autor: Rosalie Nijssen, Milou G.M. van de Schans, Robin S. Wegh, Yvette J. C. Bolck, Bjorn J.A. Berendsen, Larissa J. M. Jansen

Publikováno v: Food Additives and Contaminants-Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 39(2), 272-284
Food Additives and Contaminants-Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 39 (2022) 2

Monitoring strategies for veterinary drugs in products of animal origin are shifting towards a more risk-based approach. Such strategies not only target a limited number of predefined .substances but also facilitate detection of unexpected substances

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e94826ffd11f8eb77e067d091cde2a