Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rosalie Heilig"'
Autor:
José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W. Chen, Roderick Y. H. Lim, Petr Broz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation.
Externí odkaz:
https://doaj.org/article/6cea1f719e794133aac06f44406b21f2
Autor:
Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3846-3859 (2017)
Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzym
Externí odkaz:
https://doaj.org/article/caf0ef9e648d468094e235c5382d0983
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Francisella tularensis is the causative agent of the life-threatening disease tularemia. However, the molecular tools to study Francisella are limited. Especially, expression plasmids are sparse and difficult to use, as they are unstable and prone to
Externí odkaz:
https://doaj.org/article/fc67a43a9b114fbea63c80625357e28b
Publikováno v:
Biochemical Society Transactions. 51:457-472
Cytosolic DNA is recognized by the innate immune system as a potential threat. During apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic GMP–AMP synthase (cGAS) to promote a pro-inflammatory type I interferon re
Autor:
Kai Cao, Joel S. Riley, Rosalie Heilig, Alfredo E. Montes-Gómez, Esmee Vringer, Kevin Berthenet, Catherine Cloix, Yassmin Elmasry, David G. Spiller, Gabriel Ichim, Kirsteen J. Campbell, Andrew P. Gilmore, Stephen W.G. Tait
Publikováno v:
Developmental Cell
Developmental Cell, 2022, ⟨10.1016/j.devcel.2022.03.019⟩
Developmental Cell, 2022, ⟨10.1016/j.devcel.2022.03.019⟩
International audience; Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer is poorly understood. We find that mitochondrial dysfunction promotes DNA damage under conditions of increased ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b5a3fe3466b37d4eb9fcfa27f500e
https://eprints.gla.ac.uk/268296/1/268296.pdf
https://eprints.gla.ac.uk/268296/1/268296.pdf
Publikováno v:
Life Science Alliance
Autor:
Petr Broz, Etienne Meunier, Lorenzo Sborgi, Rosalie Heilig, Sebastian Hiller, Mathias S. Dick
Publikováno v:
European Journal of Immunology. 48:584-592
The pro-inflammatory cytokine IL-1β is well known for its role in host defense and the initiation of potent inflammatory responses. It is processed from its inactive pro-form by the inflammatory caspase-1 into its mature bioactive form, which is the
Autor:
Roland F. Dreier, Ritu Mishra, Jürgen Ruland, Katharina S. Schneider, Tamara Cikovic, Jan Sodenkamp, Oliver Gorka, Ronald Naumann, Rosalie Heilig, Mathias S. Dick, Petr Broz, Etienne Meunier, Benedikt S. Saller, Christina J. Groß, Bernhard Kuster, Olaf Groß, Guillaume Médard
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3846-3859 (2017)
Cell Reports
Cell reports, vol. 21, no. 13, pp. 3846-3859
Cell Reports
Cell reports, vol. 21, no. 13, pp. 3846-3859
Summary Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressi
Autor:
Christopher J. Farady, Benjamin Demarco, Kaiwen W. Chen, Andreas Boettcher, Petr Broz, Kateryna Shkarina, Rosalie Heilig, Pawel Pelczar
Publikováno v:
The EMBO Journal
EMBO J
The EMBO journal, vol. 38, no. 10
EMBO J
The EMBO journal, vol. 38, no. 10
Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase-1, caspase-4, caspase-5 and caspase-11. These caspases cleave and activate the pore-forming protein gasdermin D (GSDMD) to induce membrane damage. By contrast, apopt
Autor:
Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Daniel J. Müller, Henning Stahlberg, Christopher J. Farady, Petr Broz, Rosalie Heilig, Estefania Mulvihill, Joka Pipercevic
Publikováno v:
The EMBO journal
The EMBO Journal
The EMBO Journal, 35 (16)
The EMBO Journal
The EMBO Journal, 35 (16)
Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals. Pyroptotic cell death