Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rosalie E Lawrence"'
Publikováno v:
eLife, Vol 11 (2022)
In eukaryotic cells, stressors reprogram the cellular proteome by activating the integrated stress response (ISR). In its canonical form, stress-sensing kinases phosphorylate the eukaryotic translation initiation factor eIF2 (eIF2-P), which ultimatel
Externí odkaz:
https://doaj.org/article/30642cef1e944cc681ec4e83b75f1e71
Autor:
Michael Schoof, Lan Wang, J. Zachery Cogan, Rosalie E. Lawrence, Morgane Boone, Jennifer Deborah Wuerth, Adam Frost, Peter Walter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Viral infection triggers the integrated stress response (ISR) by phosphorylation of the translation initiation factor eIF2 which becomes an inhibitor of eIF2B. Here the authors show that the NSs protein of Sandfly Fever Sicilian virus allows evasion
Externí odkaz:
https://doaj.org/article/fb43fe2ba08349d09e3c0b1f51df65b5
Autor:
Justin A. De Leon, Jiazhang Qiu, Christopher J. Nicolai, Jessica L. Counihan, Kevin C. Barry, Li Xu, Rosalie E. Lawrence, Brian M. Castellano, Roberto Zoncu, Daniel K. Nomura, Zhao-Qing Luo, Russell E. Vance
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2031-2038 (2017)
All pathogens must acquire nutrients from their hosts. The intracellular bacterial pathogen Legionella pneumophila, the etiological agent of Legionnaires’ disease, requires host amino acids for growth within cells. The mechanistic target of rapamyc
Externí odkaz:
https://doaj.org/article/5471c9ca16a2435a881c2dc09deba9c1
Autor:
Vladislav Belyy, Sheng-Min Shih, Jigar Bandaria, Yongjian Huang, Rosalie E. Lawrence, Roberto Zoncu, Ahmet Yildiz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Tracking single molecules in living cells is difficult or impractical owing to their high density. Here the authors introduce a technique of repeatedly photobleaching fluorophores at the boundary of a region of interest, thereby controlling the numbe
Externí odkaz:
https://doaj.org/article/77efbc9571114b969331b9cd398322cf
Autor:
Rosalie E Lawrence, Sophie Shoemaker, Aniliese Deal, Smriti Sangwan, Aditya Anand, Lan Wang, Susan Marqusee, Peter Walter
The Integrated Stress Response (ISR) enables cells to survive a variety of acute stresses, but chronic activation of the ISR underlies age-related diseases. ISR signaling down-regulates translation and activates expression of stress-responsive factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d70f42c7d1bf9d31d23e5d480b3eec5
https://doi.org/10.1101/2022.12.22.521453
https://doi.org/10.1101/2022.12.22.521453
Publikováno v:
Nature structural & molecular biology, vol 27, iss 11
Nature structural & molecular biology
Nature structural & molecular biology
The Rag GTPases (Rags) recruit mTORC1 to the lysosomal membrane in response to nutrients, where it is then activated in response to energy and growth factor availability. The lysosomal folliculin (FLCN) complex (LFC) consists of the inactive Rag dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f4fdc601121088f4a8626e88152fb0
https://doi.org/10.1038/s41594-020-0490-9
https://doi.org/10.1038/s41594-020-0490-9
Publikováno v:
eLife. 11
In eukaryotic cells, stressors reprogram the cellular proteome by activating the integrated stress response (ISR). In its canonical form, stress-sensing kinases phosphorylate the eukaryotic translation initiation factor eIF2 (eIF2-P), which ultimatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c71e28191268c12fe8b0a6c5ea76d21
https://pubmed.ncbi.nlm.nih.gov/35416150
https://pubmed.ncbi.nlm.nih.gov/35416150
Autor:
Roberto Zoncu, Rosalie E. Lawrence
Publikováno v:
Nature Cell Biology. 21:133-142
Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth, division and differentiation. Lysosomes interface physically and functionally with other organelles, and the master regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79371255a32ffc227b48ca22b2908a66
https://doi.org/10.1038/s41556-018-0244-7
https://doi.org/10.1038/s41556-018-0244-7
The mechanistic target of rapamycin complex 1 (mTORC1) couples cell growth to nutrient, energy and growth factor availability (1–3). mTORC1 is activated at the lysosomal membrane when amino acids are replete via the Rag guanosine triphosphatases (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7acc47b213b9b6a9ab38a4e33d5e248
https://doi.org/10.1101/2020.07.28.225524
https://doi.org/10.1101/2020.07.28.225524