Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rosalba Perrone"'
Autor:
Rosalba Perrone, Prasanna Vadhana Ashok Kumaar, Lauren Haky, Cosmo Hahn, Rebeccah Riley, Julia Balough, Giuliana Zaza, Bikem Soygur, Kaitlyn Hung, Leandro Prado, Herbert G. Kasler, Ritesh Tiwari, Hiroyuki Matsui, Genesis Vega Hormazabal, Indra Heckenbach, Morten Scheibye-Knudsen, Francesca E. Duncan, Eric Verdin
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107949- (2023)
Summary: Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show
Externí odkaz:
https://doaj.org/article/b684e354f37142c3801059b7ca25046d
Autor:
Rosalba Perrone, Enrico Lavezzo, Erika Riello, Riccardo Manganelli, Giorgio Palù, Stefano Toppo, Roberta Provvedi, Sara N. Richter
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), one of the top 10 causes of death worldwide in 2015. The recent emergence of strains resistant to all current drugs urges the development of compounds with new mechanism
Externí odkaz:
https://doaj.org/article/83fdf0d3a1ff4372951f0ab8d77f8fdc
Autor:
Sara Callegaro, Rosalba Perrone, Matteo Scalabrin, Filippo Doria, Giorgio Palù, Sara N. Richter
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the
Externí odkaz:
https://doaj.org/article/3cce0b60960242b6831f570265d79d7b
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter. Folding of HIV-1 LT
Externí odkaz:
https://doaj.org/article/93fd701a8a2743ff8827e3e7d8a9ac41
Autor:
Enrico Lavezzo, Michele Berselli, Ilaria Frasson, Rosalba Perrone, Giorgio Palù, Alessandra R Brazzale, Sara N Richter, Stefano Toppo
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006675 (2018)
G-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in organisms. G-quadruplexes are present in eukaryotes, prokaryotes, and viruses. In the latter, mounting evidence indicates their key
Externí odkaz:
https://doaj.org/article/c648b46eb4964041aafca1d8e2d27290
Autor:
Sara Artusi, Emanuela Ruggiero, Matteo Nadai, Beatrice Tosoni, Rosalba Perrone, Annalisa Ferino, Irene Zanin, Luigi Xodo, Louis Flamand, Sara N. Richter
Publikováno v:
Viruses, Vol 13, Iss 2, p 196 (2021)
The herpes simplex virus 1 (HSV-1) genome is extremely rich in guanine tracts that fold into G-quadruplexes (G4s), nucleic acid secondary structures implicated in key biological functions. Viral G4s were visualized in HSV-1 infected cells, with massi
Externí odkaz:
https://doaj.org/article/1a858be339c2455292b3432027bb3ef6
Autor:
Rosalba Perrone, Matteo Nadai, Jerrod A Poe, Ilaria Frasson, Manlio Palumbo, Giorgio Palù, Thomas E Smithgall, Sara N Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73121 (2013)
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome. In particular, they have
Externí odkaz:
https://doaj.org/article/24f856fea414412cadb23b059038d14d
Autor:
Rosalba Perrone, Prasanna Vadhana Ashok Kumaar, Lauren Haky, Cosmo Hahn, Rebeccah Riley, Julia Balough, Giuliana Zaza, Bikem Soygur, Kaitlyn Hung, Leandro Prado, Herbert G. Kasler, Ritesh Tiwari, Hiroyuki Matsui, Genesis Vega Hormazabal, Francesca Elizabeth Duncan, Eric Verdin
SummaryMammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0e4ebff663b283942556f45aad1b7a9
https://doi.org/10.1101/2023.05.08.539779
https://doi.org/10.1101/2023.05.08.539779
Autor:
Emanuela Ruggiero, Ilaria Frasson, Elena Tosoni, Matteo Scalabrin, Rosalba Perrone, Maja Marušič, Janez Plavec, Sara N. Richter
Publikováno v:
ACS Infectious Diseases. 8:958-968
HIV-1 integrated long terminal repeat (LTR) promoter activity is modulated by folding of its G-rich region into non-canonical nucleic acids structures, such as G-quadruplexes (G4s), and their interaction with cellular proteins. Here, by a combined pu
Publikováno v:
Nat Rev Mol Cell Biol
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NA