Single-cell analyses of Crohn's disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions.

Autor: Jaeger N; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Gamini R; Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Cella M; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Schettini JL; Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.; Global Gene Therapy, Takeda Pharmaceuticals, Cambridge, MA, USA., Bugatti M; Department of Pathology, University of Brescia, Brescia, Italy., Zhao S; Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.; AbSci Inc, Vancouver, WA, USA., Rosadini CV; Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Esaulova E; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Di Luccia B; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Kinnett B; Division of Gastroenterology, Washington University School of Medicine, St Louis, MO, USA., Vermi W; Department of Pathology, University of Brescia, Brescia, Italy., Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Wynn TA; Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Xavier RJ; Immunology Program, Infectious Disease and Microbiome Program, Broad Institute of MIT, Cambridge, MA, USA., Jelinsky SA; Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. mcolonna@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1921. Date of Electronic Publication: 2021 Mar 26.

Control of the innate immune response by the mevalonate pathway.

Autor: Akula MK; Division of Rheumatology and Immunology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.; Sahlgrenska Cancer Center, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden., Shi M; Division of Rheumatology and Immunology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA., Jiang Z; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Foster CE; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Miao D; Division of Rheumatology and Immunology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA., Li AS; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Zhang X; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Gavin RM; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Forde SD; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Germain G; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Carpenter S; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Rosadini CV; Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Gritsman K; Department of Medicine, Albert Einstein College of Medicine, New York City, New York, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York City, New York, USA., Chae JJ; Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Hampton R; Division of Biology, University of California San Diego, La Jolla, California, USA., Silverman N; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Gravallese EM; Division of Rheumatology, Department of Medicine, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Kagan JC; Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Fitzgerald KA; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Kastner DL; Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Golenbock DT; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA., Bergo MO; Sahlgrenska Cancer Center, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden., Wang D; Division of Rheumatology and Immunology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.; Division of Infectious Diseases and Immunology, the University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Publikováno v: Nature immunology [Nat Immunol] 2016 Aug; Vol. 17 (8), pp. 922-9. Date of Electronic Publication: 2016 Jun 06.

Microbial strategies for antagonizing Toll-like-receptor signal transduction.

Autor: Rosadini CV; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA., Kagan JC; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: jonathan.kagan@childrens.harvard.edu.

Publikováno v: Current opinion in immunology [Curr Opin Immunol] 2015 Feb; Vol. 32, pp. 61-70. Date of Electronic Publication: 2015 Jan 20.

Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.

Autor: Paquette N; Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Jul 31; Vol. 109 (31), pp. 12710-5. Date of Electronic Publication: 2012 Jul 16.

Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene.

Autor: Harrington JC; Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave., N., S6-242, Worcester, MA 01655, USA., Wong SM, Rosadini CV, Garifulin O, Boyartchuk V, Akerley BJ

Publikováno v: Infection and immunity [Infect Immun] 2009 May; Vol. 77 (5), pp. 1945-58. Date of Electronic Publication: 2009 Mar 16.