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pro vyhledávání: '"Rosa de Gregorio"'
Autor:
Victor Calvo, Rosa de Gregorio, Estrella Sánchez-Góngora, Carlos Lisbona, Luis A. Pérez-Jurado, Alicia Ballester, Susana Alemany
Publikováno v:
Journal of Biological Chemistry. 275:31379-31386
COT/Tpl-2 proto-oncogene encodes a serine/threonine kinase implicated in cellular activation. In this study we have identified the human COT gene promoter region and three different human COT transcripts. These transcripts, with the same initiation s
Publikováno v:
The Journal of biological chemistry. 276(29)
Cyclooxygenase-2 (COX-2) is induced in human T lymphocytes upon T cell receptor triggering. Here we report that Cot kinase, a mitogen-activated protein kinase kinase kinase involved in T cell activation, up-regulates COX-2 gene expression in Jurkat T
Autor:
Pablo Ortiz, Susana Alemany, Rosa de Gregorio, Carmen Campos, Raquel Garcı́a-Nieto, Federico Gago
Publikováno v:
e_Buah Biblioteca Digital Universidad de Alcalá
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The ability of metamizol to inhibit cyclooxygenase-l and cyclooxygenase-2 activities has been evaluated using different cyclooxygenase sources. Metamizol inhibited purified cyclooxygenase-l and cyclooxygenase-2 with an IC50 of about 150 mu g/ml. A si