Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Rosa Spinelli"'
Autor:
Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith, Francesco Beguinot
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormalities contribute to earl
Externí odkaz:
https://doaj.org/article/67d0a5fc91c74ab8832d99e8826746b5
Autor:
Rosa Spinelli, Ritesh Kumar Baboota, Silvia Gogg, Francesco Beguinot, Matthias Blüher, Annika Nerstedt, Ulf Smith
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and aging increases the burden of CS in all major metabolic tissues. However, CS is also increased in adult obesity, type 2 diabetes (T2D), and nonalcoholic fatty li
Externí odkaz:
https://doaj.org/article/385566925a69478882f3d28fa1bafa44
Autor:
Ritesh K. Baboota, Rosa Spinelli, Malin C. Erlandsson, Bruna B. Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria I. Bokarewa, Jeremie Boucher, C. Ronald Kahn, Ulf Smith
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101558- (2022)
Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-
Externí odkaz:
https://doaj.org/article/82af05ba8e3a4d02a32750880a3b60a8
Autor:
Luca Parrillo, Rosa Spinelli, Michele Longo, Federica Zatterale, Gianluca Santamaria, Alessia Leone, Michele Campitelli, Gregory Alexander Raciti, Francesco Beguinot
Publikováno v:
Cells, Vol 12, Iss 16, p 2090 (2023)
The transcription factor HOXA5, from the HOX gene family, has long been studied due to its critical role in physiological activities in normal cells, such as organ development and body patterning, and pathological activities in cancer cells. Nonethel
Externí odkaz:
https://doaj.org/article/862612a4bea44cc08d945e65e8d35417
Autor:
Alessia Leone, Antonella Nicolò, Immacolata Prevenzano, Federica Zatterale, Michele Longo, Antonella Desiderio, Rosa Spinelli, Michele Campitelli, Domenico Conza, Gregory Alexander Raciti, Francesco Beguinot, Cecilia Nigro, Claudia Miele
Publikováno v:
Cells, Vol 12, Iss 13, p 1741 (2023)
Adipose-derived stem cells (ADSCs) play a crucial role in angiogenesis and repair of damaged tissues. However, in pathological conditions including diabetes, ADSC function is compromised. This work aims at evaluating the effect of Methylglyoxal (MGO)
Externí odkaz:
https://doaj.org/article/ae86b98c3888430b893c0a56643f7c45
Autor:
Luca Parrillo, Rosa Spinelli, Mattia Costanzo, Pasqualina Florese, Serena Cabaro, Antonella Desiderio, Immacolata Prevenzano, Gregory Alexander Raciti, Ulf Smith, Claudia Miele, Pietro Formisano, Raffaele Napoli, Francesco Beguinot
Publikováno v:
Cells, Vol 11, Iss 4, p 728 (2022)
Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose tissue (SAT) and subcutaneous adipocyte hypertrophy well before diabete
Externí odkaz:
https://doaj.org/article/c5fb346355f44d8097e2c7d9804d2b22
Autor:
Gregory Alexander Raciti, Francesca Fiory, Michele Campitelli, Antonella Desiderio, Rosa Spinelli, Michele Longo, Cecilia Nigro, Giacomo Pepe, Eduardo Sommella, Pietro Campiglia, Pietro Formisano, Francesco Beguinot, Claudia Miele
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193704 (2018)
Metabolic and/or endocrine dysfunction of the white adipose tissue (WAT) contribute to the development of metabolic disorders, such as Type 2 Diabetes (T2D). Therefore, the identification of products able to improve adipose tissue function represents
Externí odkaz:
https://doaj.org/article/d569d354c67048d9af08c2a8461034e7
Autor:
Simona Damiano, Roberta Fusco, Annalisa Morano, Mariarosaria De Mizio, Roberto Paternò, Antonella De Rosa, Rosa Spinelli, Stefano Amente, Rodolfo Frunzio, Paolo Mondola, Francoise Miot, Paolo Laccetti, Mariarosaria Santillo, Enrico Vittorio Avvedimento
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34405 (2012)
Dual Oxidases (DUOX) 1 and 2 are efficiently expressed in thyroid, gut, lung and immune system. The function and the regulation of these enzymes in mammals are still largely unknown. We report here that DUOX 1 and 2 are expressed in human neuroblasto
Externí odkaz:
https://doaj.org/article/52052805ad1f448c8f584a9ebdabad16
Autor:
Miele, Alessia Leone, Antonella Nicolò, Immacolata Prevenzano, Federica Zatterale, Michele Longo, Antonella Desiderio, Rosa Spinelli, Michele Campitelli, Domenico Conza, Gregory Alexander Raciti, Francesco Beguinot, Cecilia Nigro, Claudia
Publikováno v:
Cells; Volume 12; Issue 13; Pages: 1741
Adipose-derived stem cells (ADSCs) play a crucial role in angiogenesis and repair of damaged tissues. However, in pathological conditions including diabetes, ADSC function is compromised. This work aims at evaluating the effect of Methylglyoxal (MGO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::033458b559a142205edcbc9399919853
Autor:
Rosa Spinelli, Pasqualina Florese, Luca Parrillo, Federica Zatterale, Michele Longo, Vittoria D’Esposito, Antonella Desiderio, Annika Nerstedt, Birgit Gustafson, Pietro Formisano, Claudia Miele, Gregory Alexander Raciti, Raffaele Napoli, Ulf Smith, Francesco Beguinot
Publikováno v:
Aging Cell. 21
Senescence of adipose precursor cells (APC) impairs adipogenesis, contributes to the age-related subcutaneous adipose tissue (SAT) dysfunction, and increases risk of type 2 diabetes (T2D). First-degree relatives of T2D individuals (FDR) feature restr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184466bf7670c38fe470dee09c5319f5
https://doi.org/10.1111/acel.13557
https://doi.org/10.1111/acel.13557