Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Rosa S. P. Beddington"'
Autor:
Shankar Srinivas, James C. Smith, Tristan A. Rodriguez, Melanie Clements, Rosa S. P. Beddington
The anterior visceral endoderm (AVE) is an extra-embryonic tissue required for specifying anterior pattern in the mouse embryo. The AVE is induced at the distal tip of the 5.5 dpc embryo and then migrates to the prospective anterior, where it imparts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6630b1a27251ffea64142ded24623b66
https://ora.ox.ac.uk/objects/uuid:e6bc36da-a874-4236-a95f-9d28949074c6
https://ora.ox.ac.uk/objects/uuid:e6bc36da-a874-4236-a95f-9d28949074c6
Autor:
Tristan A. Rodriguez, Melanie Clements, Shankar Srinivas, Rosa S. P. Beddington, James C. Smith
Publikováno v:
Development. 131:1157-1164
The anterior visceral endoderm (AVE) of the mouse embryo is a specialised extra-embryonic tissue that is essential for anterior patterning of the embryo. It is characterised by the expression of anterior markers such as Hex, Cerberus-like and Lhx1. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cf2f986120765a8a92946f541715b7
https://doi.org/10.1242/dev.01005
https://doi.org/10.1242/dev.01005
Publikováno v:
Development. 131:797-806
In animal development, digestive tissues emerge from different positions of the endoderm as a result of patterning signals from overlying mesoderm. Although embryonic tissue movement during gastrulation generates an initial positional relationship be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d82e8ba4572864e322e5a35084e2d9
https://doi.org/10.1242/dev.00965
https://doi.org/10.1242/dev.00965
Autor:
Xin Sa, Rosa S. P. Beddington, Melanie Clements, Duncan B. Sparrow, Sally L. Dunwoodie, Ronald A. Conlon
Publikováno v:
Development. 129:1795-1806
A loss-of-function mutation in the mouse delta-like3 (Dll3) gene has been generated following gene targeting, and results in severe axial skeletal defects. These defects, which consist of highly disorganised vertebrae and costal defects, are similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a060303865f48372de07b4467cc120b
https://doi.org/10.1242/dev.129.7.1795
https://doi.org/10.1242/dev.129.7.1795
Autor:
Andrew J. Copp, Juan Pedro Martinez Barbera, Rosa S. P. Beddington, Tristan A. Rodriguez, Wolfgang Weninger, Nicholas D. E. Greene, Antonio Simeone, Sally L. Dunwoodie
Publikováno v:
Human Molecular Genetics. 11:283-293
Cited2 (also Mrg1/p35srj) is a member of a new conserved gene family that is expressed during mouse development and in adult tissues. In order to investigate the function of Cited2 during mouse embryogenesis, we introduced a null mutation into the Ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b76ad35ec933dfc7801b0db76b90cfd
https://doi.org/10.1093/hmg/11.3.283
https://doi.org/10.1093/hmg/11.3.283
Autor:
James C. Smith, Elena S. Casey, Rosa S. P. Beddington, Richard M. Harland, Tristan A. Rodriguez
Publikováno v:
Developmental Biology. 234(2):304-316
In the mouse, embryological and genetic studies have indicated that two spatially distinct signalling centres, the anterior visceral endoderm and the node and its derivatives, are required for the correct patterning of the anterior neural ectoderm. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1c1ca3699dced0c6dce6b4de58d00c
Publikováno v:
Developmental Biology. 223:422-430
The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early mouse embryogenesis. Previous studies have shown that Hesx1 is essential for normal murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f94dc804a333e3000c00fc21105c115
https://doi.org/10.1006/dbio.2000.9757
https://doi.org/10.1006/dbio.2000.9757
Autor:
Paul Q. Thomas, Rajeev Gupta, Peter C. Hindmarsh, Jeremy K.H. Wales, Joshua M. Brickman, Mehul T. Dattani, Iain C. A. F. Robinson, Rosa S. P. Beddington, Juan Pedro Martinez-Barbera
Publikováno v:
Hormone Research in Paediatrics. 53:26-33
Septo-optic dysplasia (SOD) is a highly variable condition characterized by midline neurological abnormalities associated with pituitary hypoplasia and optic nerve hypoplasia. The aetiology is unknown. Mutant mice, in which a novel homeobox gene, Hes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04b641d25db10888d1fb092c34f261d
https://doi.org/10.1159/000053201
https://doi.org/10.1159/000053201
Publikováno v:
Genes & Development. 13:3149-3159
We report a new role for Wnt signaling in the vertebrate embryo: the induction of neural tissue from ectoderm. Early expression of mouse wnt8, Xwnt8, beta-catenin, or dominant-negative GSK3 induces the expression of neural-specific markers and inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954b7de6558a05e32cd83b247478dd2f
https://doi.org/10.1101/gad.13.23.3149
https://doi.org/10.1101/gad.13.23.3149
Publikováno v:
Mechanisms of Development. 79:29-37
The midline has a theoretical role in the development of left–right asymmetry, and this is supported by both genetic analyses and experimental manipulation of midline structures in vertebrates. The mouse brachyury (T) gene encodes a transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c853599faa786c3c506ef63b240caf9
https://doi.org/10.1016/s0925-4773(98)00166-x
https://doi.org/10.1016/s0925-4773(98)00166-x