Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Rosa Planells"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here the authors sh
Externí odkaz:
https://doaj.org/article/522fb48cb1dc42bd81e0cdee18ac8bb0
Autor:
Slaven Erceg, Sergio Laínez, Mohammad Ronaghi, Petra Stojkovic, Maria Amparo Pérez-Aragó, Victoria Moreno-Manzano, Rubén Moreno-Palanques, Rosa Planells-Cases, Miodrag Stojkovic
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2122 (2008)
BACKGROUND: Human embryonic stem cells (hESC) provide a unique model to study early events in human development. The hESC-derived cells can potentially be used to replace or restore different tissues including neuronal that have been damaged by disea
Externí odkaz:
https://doaj.org/article/4868f195b09644d4a31c08d13d2b987a
Autor:
Karen I. López-Cayuqueo, Rosa Planells-Cases, Matthias Pietzke, Anna Oliveras, Stefan Kempa, Sebastian Bachmann, Thomas J. Jentsch
Publikováno v:
Journal of the American Society of Nephrology
Volume-regulated anion channels (VRACs) are heterohexamers of LRRC8A with LRRC8B, -C, -D, or -E in various combinations. Depending on the subunit composition, these swelling-activated channels conduct chloride, amino acids, organic osmolytes, and dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f22e220a20d9f159b3958ed938881e
https://doi.org/10.1681/asn.2021111458
https://doi.org/10.1681/asn.2021111458
Autor:
Carmen F Ludwig, Rosa Planells-Cases, Till Stuhlmann, Stefanie Weinert, Dorothea Deuschel, Dmytro Puchkov, Thomas J. Jentsch, Niclas Gimber, Gaia Novarino, Karen I. López-Cayuqueo, Zohreh Farsi
Publikováno v:
The EMBO Journal
EMBO J
EMBO J
CLC chloride/proton exchangers may support acidification of endolysosomes and raise their luminal Cl− concentration. Disruption of endosomal ClC‐3 causes severe neurodegeneration. To assess the importance of ClC‐3 Cl−/H+ exchange, we now gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1173b2e9df5f36950b66a727c4b740
http://europepmc.org/articles/PMC7196918
http://europepmc.org/articles/PMC7196918
Autor:
María Camprubí-Robles, Jun Yang, Natalia Cuesta, Antonio Ferrer-Montiel, Amparo Andrés-Borderia, Maria Grazia Ciardo, Pierluigi Valente, Rosa Planells-Cases
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
The expression and function of TRPV1 are influenced by its interaction with cellular proteins. Here, we identify Whirlin, a cytoskeletal PDZ-scaffold protein implicated in hearing, vision and mechanosensory transduction, as an interacting partner of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f536f793fe75301c5ee804a5b6695a
https://doi.org/10.1016/j.bbamcr.2015.10.016
https://doi.org/10.1016/j.bbamcr.2015.10.016
Autor:
Darius Lutter, Charlotte Guyader, S. Momsen Reincke, Deborah A Elger, Felizia K. Voss, Florian Ullrich, Vincent A. Blomen, Thomas J. Jentsch, Asli Kucukosmanoglu, Sven Rottenberg, Piet Borst, Daniel J. Vis, Guotai Xu, Lodewyk F. A. Wessels, Tobias Stauber, Thijn R. Brummelkamp, Nora M. Gerhards, Rosa Planells-Cases
Publikováno v:
The EMBO journal, 34(24): 2985-3073
The EMBO Journal
EMBO Journal, 34(24), 2993-3008. Wiley-Blackwell
ResearcherID
Planells-Cases, Rosa; Lutter, Darius; Guyader, Charlotte; Gerhards, Nora Merete; Ullrich, Florian; Elger, Deborah A; Kucukosmanoglu, Asli; Xu, Guotai; Voss, Felizia K; Reincke, S Momsen; Stauber, Tobias; Blomen, Vincent A; Vis, Daniel J; Wessels, Lodewyk F; Brummelkamp, Thijn R; Borst, Piet; Rottenberg, Sven; Jentsch, Thomas J (2015). Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. The EMBO Journal, 34(24), pp. 2993-3008. EMBO Press 10.15252/embj.201592409
Planells-Cases, R, Lutter, D, Guyader, C, Gerhards, N M, Ullrich, F, Elger, D A, Kucukosmanoglu, A, Xu, G, Voss, F K, Reincke, S M, Stauber, T, Blomen, V A, Vis, D J, Wessels, L F, Brummelkamp, T R, Borst, P, Rottenberg, S & Jentsch, T J 2015, ' Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs ', EMBO Journal, vol. 34, no. 24, pp. 2993-3008 . https://doi.org/10.15252/embj.201592409
EMBO JOURNAL
The EMBO Journal
EMBO Journal, 34(24), 2993-3008. Wiley-Blackwell
ResearcherID
Planells-Cases, Rosa; Lutter, Darius; Guyader, Charlotte; Gerhards, Nora Merete; Ullrich, Florian; Elger, Deborah A; Kucukosmanoglu, Asli; Xu, Guotai; Voss, Felizia K; Reincke, S Momsen; Stauber, Tobias; Blomen, Vincent A; Vis, Daniel J; Wessels, Lodewyk F; Brummelkamp, Thijn R; Borst, Piet; Rottenberg, Sven; Jentsch, Thomas J (2015). Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. The EMBO Journal, 34(24), pp. 2993-3008. EMBO Press 10.15252/embj.201592409
Planells-Cases, R, Lutter, D, Guyader, C, Gerhards, N M, Ullrich, F, Elger, D A, Kucukosmanoglu, A, Xu, G, Voss, F K, Reincke, S M, Stauber, T, Blomen, V A, Vis, D J, Wessels, L F, Brummelkamp, T R, Borst, P, Rottenberg, S & Jentsch, T J 2015, ' Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs ', EMBO Journal, vol. 34, no. 24, pp. 2993-3008 . https://doi.org/10.15252/embj.201592409
EMBO JOURNAL
Although platinum‐based drugs are widely used chemotherapeutics for cancer treatment, the determinants of tumor cell responsiveness remain poorly understood. We show that the loss of subunits LRRC8A and LRRC8D of the heteromeric LRRC8 volume‐regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a24fce2d0a948aa4340f62de1d8b6aa
http://www.scopus.com/inward/record.url?scp=84955178178&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=84955178178&partnerID=8YFLogxK
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:385-393
A major player of vertebrate cell volume regulation is the volume-regulated anion channel (VRAC), which conducts halide ions and organic osmolytes to counteract osmotic imbalances. The molecular entity of this channel was unknown until very recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34a1113ca3de6746336d26e5e964080
https://doi.org/10.1007/s00424-015-1766-5
https://doi.org/10.1007/s00424-015-1766-5
Autor:
Asia Fernández-Carvajal, Jordi Bujons, Angel Messeguer, Miquel Vidal-Mosquera, Antonio Ferrer-Montiel, Rosa Planells-Cases, Alejandra Moure, José M. González-Ros, Pierluigi Valente
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
JOURNAL OF MEDICINAL CHEMISTRY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
instname
JOURNAL OF MEDICINAL CHEMISTRY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
The thermosensory transient receptor potential vanilloid 1 channel (TRPV1) is a polymodal receptor activated by physical and chemical stimuli. TRPV1 activity is drastically potentiated by proinflammatory agents released upon tissue damage. Given the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa22b6885dfa239975adae1071d9a68
https://doi.org/10.1021/jm200981s
https://doi.org/10.1021/jm200981s
Publikováno v:
The Open Pain Journal. 3:108-116
Nociceptor sensitization is a process triggered by proinflammatory factors that result in a significant increase in neuronal excitability by affecting both the threshold and frequency of action potential firing. The increased sensory neu- ron activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb960979b694227ab14756979dd23c2
https://doi.org/10.2174/1876386301003010108
https://doi.org/10.2174/1876386301003010108
Publikováno v:
The FASEB Journal. 23:3722-3733
Potentiation of the pain-integrator ion channel transient receptor potential vanilloid type 1 (TRPV1) underlies thermal hyperalgesia mediated by a variety of proinflammatory factors. Two complementary mechanisms of TRPV1 inflammatory sensitization ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79bd0969f1daa3cbf2db7f64903ac19
https://doi.org/10.1096/fj.09-134346
https://doi.org/10.1096/fj.09-134346