Towards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel

Autor: Blanca de Unamuno Bustos, Rosa Murria Estal, Gema Pérez Simó, Inmaculada de Juan Jimenez, Begoña Escutia Muñoz, Mercedes Rodríguez Serna, Victor Alegre de Miquel, Margarita Llavador Ros, Rosa Ballester Sánchez, Eduardo Nagore Enguídanos, Sarai Palanca Suela, Rafael Botella Estrada

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Molecular diagnostics are increasingly performed routinely in the diagnosis and management of patients with melanoma due to the development of novel therapies that target specific genetic mutations. The development of next-generation sequenc

Externí odkaz: https://doaj.org/article/e39afa7edb1547ada0b0f991d05e9aec

MiR-138-5p Suppresses Cell Growth and Migration in Melanoma by Targeting Telomerase Reverse Transcriptase

Autor: Rosa Murria Estal, Javier Simarro, Gema Pérez Simó, Antonio Sahuquillo Torralba, Rafael Botella Estrada, Estefanía Tarazón, Sarai Palanca Suela, Blanca de Unamuno Bustos

Publikováno v: Genes; Volume 12; Issue 12; Pages: 1931
Genes
Genes, Vol 12, Iss 1931, p 1931 (2021)

Recent evidence suggests the existence of a miRNA regulatory network involving human telomerase reverse transcriptase gene (hTERT), with miR-138-5p playing a central role in many types of cancers. However, little is known about the regulation of hTER

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a7c2cf7f22d988507c78991bf4ddfa

Lack of TERT promoter mutations in melanomas with extensive regression

Autor: Vicente Oliver Martínez, Blanca de Unamuno Bustos, Sarai Palanca Suela, Gema Pérez Simó, Margarita Ros, Rosa Murria Estal, Rafael Botella Estrada

Publikováno v: Journal of the American Academy of Dermatology. 74:570-572

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef15c333e1f3a01827eecce742446265
https://doi.org/10.1016/j.jaad.2015.10.003

MicroRNA signatures in hereditary breast cancer

Autor: Sarai Palanca Suela, María José Juan Fita, Rosa Murria Estal, Dolors Sánchez-Izquierdo, Pascual Bolufer Gilabert, Ángel Segura Huerta, Zaida García-Casado, Eva Barragán González, Marta Llop García, Inmaculada de Juan Jiménez, Isabel Chirivella González, Ana Beatriz Sánchez Heras, Cecilia Egoavil Rojas

Publikováno v: BREAST CANCER RESEARCH AND TREATMENT
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

This study aims to identify signatures of miR associated with hereditary, BRCA1 or BRCA2 mutation positive breast cancer (BC), and non-hereditary BC, either sporadic (SBC) or non-informative (BRCAX). Moreover, we search for signatures associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e349cabcd1e0d311600cbf999d9cae
https://doi.org/10.1007/s10549-013-2723-7

Elevated advanced oxidation protein products (AOPPs) indicate metabolic risk in severely obese children

Autor: Pilar Codoñer-Franch, Raquel Simó-Jordá, Eulalia Alonso-Iglesias, Sandra Tavárez-Alonso, Rosa Murria-Estal, Miguel Tortajada-Girbés

Publikováno v: Nutrition, metabolism, and cardiovascular diseases : NMCD. 22(3)

Background and aims The assessment of oxidative stress may aid in the identification of subsequent metabolic risk in obese children. The objective of this study was to determine whether the plasma level of advanced oxidation protein products, analyze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d91282e130c08092ff7713410c13b6
https://pubmed.ncbi.nlm.nih.gov/20708392