Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Rosa Maria Borzì"'
Autor:
Eleonora Olivotto, Manuela Minguzzi, Stefania D’Adamo, Annalisa Astolfi, Spartaco Santi, Mariagrazia Uguccioni, Kenneth B. Marcu, Rosa Maria Borzì
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract IKKα and IKKβ are essential kinases for activating NF-κB transcription factors that regulate cellular differentiation and inflammation. By virtue of their small size, chemokines support the crosstalk between cartilage and other joint comp
Externí odkaz:
https://doaj.org/article/00c09dde5874444aa957f124a45639f9
Autor:
Veronica Panichi, Irene Bissoli, Stefania D’Adamo, Flavio Flamigni, Silvia Cetrullo, Rosa Maria Borzì
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5830 (2023)
Osteoarthritis (OA) is the most common joint disease, but no effective and safe disease-modifying treatment is available. Risk factors such as age, sex, genetics, injuries and obesity can concur to the onset of the disease, variably triggering the lo
Externí odkaz:
https://doaj.org/article/d21b52781637410d961035e316a7dd3f
Autor:
Carola Cavallo, Giulia Merli, Rosa Maria Borzì, Nicoletta Zini, Stefania D’Adamo, Michele Guescini, Brunella Grigolo, Alessandro Di Martino, Spartaco Santi, Giuseppe Filardo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The therapeutic ability of Mesenchymal Stem/Stromal Cells to address osteoarthritis (OA) is mainly related to the secretion of biologically active factors, which can be found within their secreted Extracellular Vesicles including small Extra
Externí odkaz:
https://doaj.org/article/2b712d007ba24e85b83dc5651925f594
Autor:
Carola Cavallo, Giulia Merli, Nicoletta Zini, Stefania D’Adamo, Luca Cattini, Michele Guescini, Brunella Grigolo, Alessandro Di Martino, Spartaco Santi, Rosa Maria Borzì, Giuseppe Filardo
Publikováno v:
Stem Cells International, Vol 2022 (2022)
The last decade has seen exponentially growing efforts to exploit the effects of adipose derived stromal cells (ADSC) in the treatment of a wide range of chronic degenerative diseases, including osteoarthritis (OA), the most prevalent joint disorder.
Externí odkaz:
https://doaj.org/article/7e79d240fb6f4c7f83adf04f89ddac4a
Autor:
Manuela Minguzzi, Veronica Panichi, Stefania D’Adamo, Silvia Cetrullo, Luca Cattini, Flavio Flamigni, Erminia Mariani, Rosa Maria Borzì
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 12012 (2021)
Notch signaling has been identified as a critical regulator of cartilage development and homeostasis. Its pivotal role was established by both several joint specific Notch signaling loss of function mouse models and transient or sustained overexpress
Externí odkaz:
https://doaj.org/article/5a358195dec846698abc8316bc227970
Autor:
Stefania D’Adamo, Silvia Cetrullo, Veronica Panichi, Erminia Mariani, Flavio Flamigni, Rosa Maria Borzì
Publikováno v:
Cells, Vol 9, Iss 5, p 1232 (2020)
Osteoarthritis (OA) is a disease associated to age or conditions that precipitate aging of articular cartilage, a post-mitotic tissue that remains functional until the failure of major homeostatic mechanisms. OA severely impacts the national health s
Externí odkaz:
https://doaj.org/article/824cf23d7dc84663bf1d790efb076065
Autor:
Simona Neri, Rosa Maria Borzì
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 340 (2020)
Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have also emerged in the last years as extremely promising therapeutic agents
Externí odkaz:
https://doaj.org/article/13ca9f52082a4d7caf70208317e8dccb
Autor:
Silvia Cetrullo, Stefania D’Adamo, Veronica Panichi, Rosa Maria Borzì, Carla Pignatti, Flavio Flamigni
Publikováno v:
Cells, Vol 9, Iss 3, p 537 (2020)
While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are
Externí odkaz:
https://doaj.org/article/13bd2dbaf2074b669b4247a316174547
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 3, Pp 1-2 (2019)
Externí odkaz:
https://doaj.org/article/4127b738b3e6440db9ac9809874c649b
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 636 (2019)
The perspectives of regenerative medicine are still severely hampered by the host response to biomaterial implantation, despite the robustness of technologies that hold the promise to recover the functionality of damaged organs and tissues. In this s
Externí odkaz:
https://doaj.org/article/f8a144f55d7640c3b6cde5f57cdf43ad