Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Rosa M. Tolón"'
Autor:
Gonzalo Ruiz-Pérez, Samuel Ruiz de Martín Esteban, Sharai Marqués, Noelia Aparicio, M. Teresa Grande, Irene Benito-Cuesta, Ana M. Martínez-Relimpio, M. Andrea Arnanz, Rosa M. Tolón, María Posada-Ayala, Benjamin F. Cravatt, José A. Esteban, Julián Romero, Rocío Palenzuela
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background The complex pathophysiology of Alzheimer’s disease (AD) hampers the development of effective treatments. Attempts to prevent neurodegeneration in AD have failed so far, highlighting the need for further clarification of the unde
Externí odkaz:
https://doaj.org/article/04889a4e705342f5872aede81d9dbb99
Autor:
Alicia López, Noelia Aparicio, M. Ruth Pazos, M. Teresa Grande, M. Asunción Barreda-Manso, Irene Benito-Cuesta, Carmen Vázquez, Mario Amores, Gonzalo Ruiz-Pérez, Elena García-García, Margaret Beatka, Rosa M. Tolón, Bonnie N. Dittel, Cecilia J. Hillard, Julián Romero
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in the brain. This receptor is especially relevant in the context
Externí odkaz:
https://doaj.org/article/1c0c192ba5124243a8c6c06f7122bce8
Autor:
Vivian X. Zhou, William R. Drobyski, Garrett Sauber, Todd M. Stollenwerk, Alicia Tapia López, Rosa M. Tolón, Julián Romero, Cecilia J. Hillard, Cheng Yin Yuan, Richard A. Komorowski
Publikováno v:
Blood
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Graft versus host disease (GVHD) pathophysiology is a complex interplay between cells that comprise the adaptive and innate arms of the immune system. Effective prophylactic strategies are therefore contingent upon approaches that address contributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4087731083052579244d6df16be5bd4
https://doi.org/10.1182/blood.2020004871
https://doi.org/10.1182/blood.2020004871
Autor:
Irene Benito-Cuesta, Rocío Palenzuela, Noelia Aparicio, Rosa M. Tolón, Gonzalo Ruiz-Pérez, Samuel Ruiz de Martín Esteban, Ana M. Martínez-Relimpio, José A. Esteban, M. Teresa Grande, María Posada-Ayala, Julián Romero, Sharai Marqués, M Andrea Arnanz, Benjamin F. Cravatt
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Background: The complex pathophysiology of Alzheimer’s disease (AD) hampers the development of effective treatments. Attempts to prevent neurodegeneration in AD have failed so far, highlighting the need for further clarification of the underlying c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6eb699ba543a3c7bbf74c6c2f49b07
http://hdl.handle.net/10261/268096
http://hdl.handle.net/10261/268096
Autor:
Rosa M. Tolón, Silvia Ortega-Gutiérrez, M. A. Alonso Alonso Arias, Javier Ruiz, Ismael Galve-Roperh, María Laura García-Bermejo, Carolina Ruiz Romero, María Jesús García de Yébenes, Sara Valdeolivas, Guillermo García Ribas, Eva Resel, Manuel Guzmán, Justo García de Yébenes Prous, Patricia Trigo Cubillo, Jose Luis López-Sendón Moreno, Onintza Sagredo, Juan García Caldentey
Publikováno v:
Journal of Neurology. 263:1390-1400
Huntington's disease (HD) is a neurodegenerative disease for which there is no curative treatment available. Given that the endocannabinoid system is involved in the pathogenesis of HD mouse models, stimulation of specific targets within this signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f57cd82240c08c9eb83dda805011e80
https://doi.org/10.1007/s00415-016-8145-9
https://doi.org/10.1007/s00415-016-8145-9
Autor:
Gonzalo Ruiz-Pérez, M. Ruth Pazos, Alicia Tapia López, Rosa M. Tolón, M. Teresa Grande, Ana M. Martínez-Relimpio, Mario Amores, Julián Romero, Samuel Ruiz de Martín Esteban, Noelia Aparicio, Carmen Vázquez, Benjamin F. Cravatt
Publikováno v:
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
The search for novel therapies for the treatment of Alzheimer’s disease is an urgent need, due to the current paucity of available pharmacological tools and the recent failures obtained in clinical trials. Among other strategies, the modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddde8de438a28d58635a6caeb9eb5e64
http://hdl.handle.net/10641/2184
http://hdl.handle.net/10641/2184
Autor:
Marta Moreno, Cecilia J. Hillard, Carmen Vázquez, Erin C. Koester, Julián Romero, María Ruth Pazos, Rosa M. Tolón, Benjamin F. Cravatt
Publikováno v:
Neurobiology of Disease, Vol 79, Iss, Pp 41-50 (2015)
Anandamide (AEA) is an endocannabinoid (EC) that modulates multiple functions in the CNS and that is released in areas of injury, exerting putative neuroprotective actions. In the present study, we have used intravital microscopy to analyze the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3179f371fce6e9702c37f45a745b50a
https://doi.org/10.1016/j.nbd.2015.04.005
https://doi.org/10.1016/j.nbd.2015.04.005
Autor:
Ana Isabel Castillo, José Martínez-Orgado, Lourdes Ruiz-Valdepeñas, Rosa M. Tolón, Francisco Javier Fernández-Sánchez, Benjamin F. Cravatt, Carmen Vázquez, Julián Romero, Cristina Benito
Publikováno v:
British Journal of Pharmacology. 166:1474-1489
BACKGROUND AND PURPOSE The endocannabinoid system may regulate glial cell functions and their responses to pathological stimuli, specifically, Alzheimer's disease. One experimental approach is the enhancement of endocannabinoid tone by blocking the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac80532a5f6465d38ffd251c3e83ec9
https://doi.org/10.1111/j.1476-5381.2012.01889.x
https://doi.org/10.1111/j.1476-5381.2012.01889.x
Autor:
Ilia Aroyo, Onintza Sagredo, Juan Pablo Romero, Javier Fernández-Ruiz, Isabel Lastres-Becker, María Ruth Pazos, Rosa M. Tolón, Emmanuel Brouillet, Cristina Benito, Sara González, Raphael Mechoulam, Julián Romero
Publikováno v:
Glia. 57:1154-1167
Cannabinoid agonists might serve as neuroprotective agents in neurodegenerative disorders. Here, we examined this hypothesis in a rat model of Huntington's disease (HD) generated by intrastriatal injection of the mitochondrial complex II inhibitor ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965414a1def5c19f6159e8eb95f86450
https://doi.org/10.1002/glia.20838
https://doi.org/10.1002/glia.20838
Autor:
María Teresa Pérez Fernández, J.J. Fernández-Ruiz, Julián Romero, Francisco Arias, Cristina Benito, Francisca Almodóvar, María Ruth Pazos, Sara González, Mariano Álvarez, Rosa M. Tolón, Juan José Gorgojo, Conrado Fernández Rodríguez, J. L. Lledó, Manuel Nevado
Publikováno v:
Journal of Histochemistry & Cytochemistry. 56:511-516
Experimental data suggest that the endogenous cannabinoid system is involved in gastric function in different animal species. In most of them, CB1 receptors have been localized on vagal terminals innervating the external wall of the stomach. We aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42e078daa2a1a519f699417f20cb62
https://doi.org/10.1369/jhc.2008.950741
https://doi.org/10.1369/jhc.2008.950741