New drug target in protozoan parasites: the role of thioredoxin reductase

Autor: Rosa M. Andrade, Sharon L. Reed

Publikováno v: Frontiers in Microbiology, Vol 6 (2015)

Amebiasis causes approximately 70,000 deaths annually and is the third cause of death due to parasites worldwide. It is treated primarily with metronidazole, which has adverse side effects, is mutagenic and carcinogenic, and emergence of resistance i

Externí odkaz: https://doaj.org/article/38aa51567c68427bbf520cce1b2c9209

Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis

Autor: Juan D Chaparro, Uyen Phuong Tran, Grace Hwang, Ken Hirata, Rosa M. Andrade, Shara Cohn, James H. McKerrow, Sara B. T. Brenner, Timmy Cheng, Sharon L. Reed

Publikováno v: PLoS ONE
Chaparro, JD; Cheng, T; Tran, UP; Andrade, RM; Brenner, SBT; Hwang, G; et al.(2018). Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. PLOS ONE, 13(3). doi: 10.1371/journal.pone.0193982. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6jk468f6
PLoS ONE, Vol 13, Iss 3, p e0193982 (2018)
PloS one, vol 13, iss 3

Although toxoplasmosis is one of the most common parasitic infections worldwide, therapeutic options remain limited. Cathepsins, proteases that play key roles in the pathogenesis of toxoplasmosis and many other protozoan infections, are important pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f6e670ce929d34673e2304dd306824
http://europepmc.org/articles/PMC5863946

CD40-TRAF6 and Autophagy-Dependant Anti-Microbial Activity in Macrophages

Autor: Rosa M. Andrade, Carlos S. Subauste, Matthew Wessendarp

Publikováno v: Autophagy. 3:245-248

A fundamental question in host-pathogen interaction is to determine if the immune system activates fusion with the lysosomes to eradicate pathogens. We recently reported that this task is accomplished by the interaction between CD40 expressed on macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e5ba9298f85fd8147ac5abf2ed045d
https://doi.org/10.4161/auto.3717

New drug target in protozoan parasites: the role of thioredoxin reductase

Autor: Sharon L. Reed, Rosa M. Andrade

Publikováno v: Frontiers in Microbiology
Frontiers in microbiology, vol 6, iss SEP
Frontiers in Microbiology, Vol 6 (2015)
Andrade, RM; & Reed, SL. (2015). New drug target in protozoan parasites: The role of thioredoxin reductase. Frontiers in Microbiology, 6(SEP). doi: 10.3389/fmicb.2015.00975. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/41x555g0

© 2015 Andrade and Reed. Amebiasis causes approximately 70,000 deaths annually and is the third cause of death due to parasites worldwide. It is treated primarily with metronidazole, which has adverse side effects, is mutagenic and carcinogenic, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76777436f9dda041ce7b826ca981f803
http://europepmc.org/articles/PMC4588103

Antimalarials in systemic lupus erythematosus: benefits beyond disease activity

Autor: Rosa M. Andrade, Graciela S. Alarcón

Publikováno v: Future Rheumatology. 1:225-233

Antimalarials, particularly hydroxychloroquine, have proven beneficial effects beyond the control of disease activity among systemic lupus erythematosus patients. Indeed, recent data support the notion that prolonged treatment with hydroxychloroquine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e960aa85d5143d3a9248d213af23f61
https://doi.org/10.2217/17460816.1.2.225