Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rosa L. Moreno"'
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199233 (2018)
Zebrafish primary motor neurons differ from each other with respect to morphology, muscle targets and electrophysiological properties. For example, CaP has 2-3-fold larger densities of both inward and outward currents than do other motor neurons. We
Externí odkaz:
https://doaj.org/article/f05418fe538b4696bf40c972fef49eaf
Publikováno v:
eLife, Vol 4 (2015)
Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous ani
Externí odkaz:
https://doaj.org/article/9743179c702a4abd8f678b58ef8d1e1f
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199233 (2018)
PLoS ONE
PLoS ONE
Zebrafish primary motor neurons differ from each other with respect to morphology, muscle targets and electrophysiological properties. For example, CaP has 2-3-fold larger densities of both inward and outward currents than do other motor neurons. We
Publikováno v:
Journal of Visualized Experiments.
Zebrafish, first introduced as a developmental model, have gained popularity in many other fields. The ease of rearing large numbers of rapidly developing organisms, combined with the embryonic optical clarity, served as initial compelling attributes
Autor:
Wolfgang Kruse, Davina V. Gutierrez, Robert A. Hyde, Stefan Herlitze, Melanie D. Mark, Takashi Maejima, Viral Shah, Jeffrey L. Noebels, Denise Kuckelsberg, Rosa L. Moreno, Jong W. Yoo
Publikováno v:
The Journal of Neuroscience. 31:4311-4326
Inherited loss of P/Q-type calcium channel function causes human absence epilepsy, episodic dyskinesia, and ataxia, but the molecular “birthdate” of the neurological syndrome and its dependence on prenatal pathophysiology is unknown. Since these
Autor:
Angeles B. Ribera, Rosa L. Moreno
Publikováno v:
Annals of the New York Academy of Sciences. 1198:201-207
At early embryonic stages, zebrafish spinal neuron subtypes can be distinguished and accessed for physiological studies. This provides the opportunity to determine electrophysiological properties of different spinal motor neuron subtypes. Such differ
Autor:
Jing Han, Matthias Buck, Mian Xie, Rosa L. Moreno, Stefan Herlitze, Xiang Li, Alexander Hümmer, Katya Verushka Melnik-Martinez, Melanie D. Mark
Publikováno v:
Journal of Biological Chemistry. 280:23945-23959
Voltage-gated Ca2+ channels of the N-, P/Q-, and R-type and G protein inwardly rectifying K+ channels (GIRK) are modulated via direct binding of G proteins. The modulation is mediated by G protein βγ subunits. By using electrophysiological recordin
Autor:
Rosa L. Moreno, Stefan Herlitze, Melanie D. Mark, Alexander Hümmer, Oliver Delzeith, Shannon R. Gomez
Publikováno v:
Journal of Biological Chemistry. 278:49386-49400
Presynaptic Ca2+ channels are inhibited by metabotropic receptors. A possible mechanism for this inhibition is that G protein betagamma subunits modulate the binding of the Ca2+ channel beta subunit on the Ca2+ channel complex and induce a conformati
Autor:
Jing Han, Rosa L. Moreno, Mian Xie, Alexander Hümmer, Melanie D. Mark, Katya Verushka Melnik-Martinez, Stefan Herlitze
Publikováno v:
Journal of Bioenergetics and Biomembranes. 35:621-637
Functional voltage-dependent Ca2+ channel complexes are assembled by three to four subunits: alpha1, beta, alpha2delta subunits (C. Leveque et al., 1994, J. Biol Chem. 269, 6306-6312; M. W. McEnery et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88, 1109