Výsledky vyhledávání - "Rosa G. M. Lammerts"

Akademický článek

Renal Endothelial Cytotoxicity Assay to Diagnose and Monitor Renal Transplant Recipients for Anti-Endothelial Antibodies

Autor: Rosa G. M. Lammerts, Jacob van den Born, Magdalena Huberts-Kregel, Antonio W. Gomes-Neto, Mohammed R. Daha, Bouke G. Hepkema, Jan-Stephan Sanders, Robert A. Pol, Arjan Diepstra, Stefan P. Berger

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Tissue-specific nonhuman leukocyte antigen (HLA) antigens can play crucial roles in allograft immunity and have been shown to trigger humoral responses leading to rejection of HLA-matched kidney allografts. Interest in the role of endothelial-specifi

Externí odkaz: https://doaj.org/article/d942e9979e43454f80db53185f9d4f4a

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Akademický článek

Antigen and Cell-Based Assays for the Detection of Non-HLA Antibodies

Autor: Rosa G. M. Lammerts, Dania Altulea, Bouke G. Hepkema, Jan-Stephan Sanders, Jacob van den Born, Stefan P. Berger

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

To date, human leukocyte antigens (HLA) have been the major focus in the approach to acute and chronic antibody-mediated rejection (AMBR) in solid-organ transplantation. However, evidence from the clinic and published studies has shown that non-HLA a

Externí odkaz: https://doaj.org/article/29424344f24641f5939ddf0a8fd78fb1

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Akademický článek

Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney

Autor: Gesa Tiller, Rosa G. M. Lammerts, Jessy J. Karijosemito, Firas F. Alkaff, Arjan Diepstra, Robert A. Pol, Anita H. Meter-Arkema, Marc. A. Seelen, Marius C. van den Heuvel, Bouke G. Hepkema, Mohamed R. Daha, Jacob van den Born, Stefan P. Berger

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundThe role of the complement system in antibody-mediated rejection (ABMR) is insufficiently understood. We aimed to investigate the role of local and systemic complement activation in active (aABMR). We quantified complement activation marker

Externí odkaz: https://doaj.org/article/0374bcdd6fcd4646a75af8dead091dd3

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Akademický článek

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Autor: Rosa G. M. Lammerts, Ditmer T. Talsma, Wendy A. Dam, Mohamed R. Daha, Marc A. J. Seelen, Stefan P. Berger, Jacob van den Born

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and

Externí odkaz: https://doaj.org/article/2f72def49d57400aad737f1e29f2343c

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Akademický článek

Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients

Autor: Rosa G. M. Lammerts, Michele F. Eisenga, Mohammed Alyami, Mohamed R. Daha, Marc A. Seelen, Robert A. Pol, Jacob van den Born, Jan-Stephan Sanders, Stephan J. L. Bakker, Stefan P. Berger

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation. This study aimed to

Externí odkaz: https://doaj.org/article/c6fe8a66defa44a5b7f38bfb08c226e4

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