Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Rosa E. Blanco"'
Autor:
Sarah Kim, Kathleen Ochoa, Sierra E. Melli, Fawad A. K. Yousufzai, Zerian D. Barrera, Aela A. Williams, Gianna McIntyre, Esteban Delgado, James N. Bolish, Collin M. Macleod, Mary Boghos, Hayden P. Lens, Alex G. Ramos, Vincent B. Wilson, Kelly Maloney, Zachary M. Padron, Amaal H. Khan, Rosa E. Blanco, Ileana Soto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Purkinje cell (PC) loss occurs at an early age in patients and animal models of Niemann-Pick Type C (NPC), a lysosomal storage disease caused by mutations in the Npc1 or Npc2 genes. Although degeneration of PCs occurs early in NPC, little is
Externí odkaz:
https://doaj.org/article/d70f062b7cf54c8cb4206aba4396c0fe
Autor:
Larisa Kavetsky, Kayla K. Green, Bridget R. Boyle, Fawad A. K. Yousufzai, Zachary M. Padron, Sierra E. Melli, Victoria L. Kuhnel, Harriet M. Jackson, Rosa E. Blanco, Gareth R. Howell, Ileana Soto
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Niemann Pick Type-C disease (NPC) is an inherited lysosomal storage disease (LSD) caused by pathogenic variants in the Npc1 or Npc2 genes that lead to the accumulation of cholesterol and lipids in lysosomes. NPC1 deficiency causes neurodegen
Externí odkaz:
https://doaj.org/article/0a3142fa18544a06af143d5a90ca39f0
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid (RA) plays major roles during nervous system development, and during regeneration of the adult nervous system. We have previously shown that components of the RA signaling pathway are upregulated after optic nerve injury, and that exoge
Externí odkaz:
https://doaj.org/article/522f80eb89dc46ebb4c2bd9b5016ca72
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162626 (2016)
After lesions to the mammalian optic nerve, the great majority of retinal ganglion cells (RGCs) die before their axons have even had a chance to regenerate. Frog RGCs, on the other hand, suffer only an approximately 50% cell loss, and we have previou
Externí odkaz:
https://doaj.org/article/0955dc6eb3274206851fca691f7c684b
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0255196 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0255196 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid (RA) plays major roles during nervous system development, and during regeneration of the adult nervous system. We have previously shown that components of the RA signaling pathway are upregulated after optic nerve injury, and that exoge
Publikováno v:
The FASEB Journal. 33
Autor:
Harriet M. Jackson, Zachary M. Padron, Ileana Soto, Bridget R. Boyle, Fawad A. K. Yousufzai, Kayla K. Green, Victoria L. Kuhnel, Gareth R. Howell, Sierra E. Melli, Larisa Kavetsky, Rosa E. Blanco
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Niemann Pick Type-C disease (NPC) is an inherited lysosomal storage disease (LSD) caused by pathogenic variants in the Npc1 or Npc2 genes that lead to the accumulation of cholesterol and lipids in lysosomes. NPC1 deficiency causes neurodegeneration,
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Giam S. Vega-Meléndez, Rosa E. Blanco, Jonathan M. Blagburn, Clarissa Del Cueto, Valeria De La Rosa-Reyes
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0209733 (2019)
PLoS ONE
PLoS ONE
We have previously shown that a single application of the growth factors ciliary neurotrophic factor (CNTF) or fibroblast growth factor 2 (FGF-2) to the crushed optic nerve of the frog, Rana pipiens, increases the numbers and elongation rate of regen
Publikováno v:
Journal of Neuroscience Research. 92:13-23
Neurotrophins such as ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) and growth factors such as fibroblast growth factor (FGF-2) play important roles in neuronal survival and in axonal outgrowth during development. Ho