A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage

Autor: Ayyalusamy Ramamoorthy, Samuel A. Kotler, Rosa Chillemi, Carmelo La Rosa, Jeffrey R. Brender, Danilo Milardi, Valentina Greco, Dong Kuk Lee, Sebastiano Sciuto, Michele Sciacca, Messineo Concetta Lucia

Publikováno v: Biochimica et biophysica acta. Biomembranes 1860 (2018): 1793–1802. doi:10.1016/j.bbamem.2018.03.012
info:cnr-pdr/source/autori:Sciacca, Michele F. M.; Chillemi, Rosa; Sciuto, Sebastiano; Greco, Valentina; Messineo, Concetta; Kotler, Samuel A.; Lee, Dong-Kuk; Brender, Jeffrey R.; Ramamoorthy, Ayyalusamy; La Rosa, Carmelo; Milardi, Danilo/titolo:A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage/doi:10.1016%2Fj.bbamem.2018.03.012/rivista:Biochimica et biophysica acta. Biomembranes/anno:2018/pagina_da:1793/pagina_a:1802/intervallo_pagine:1793–1802/volume:1860

Type II diabetes mellitus (T2DM) is characterized by the presence of amyloid deposits of the human islet amyloid polypeptide (hIAPP) in pancreatic beta-cells. A wealth of data supports the hypothesis that hIAPP's toxicity is related to an abnormal in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb5f263efa2ae101575292b1d0f37f9
https://doi.org/10.1016/j.bbamem.2018.03.012

Polyphenol-enriched fractions from Sicilian grape pomace: HPLC–DAD analysis and antioxidant activity

Autor: Rosa Chillemi, Vincenzo Amico, Corrado Tringali, S. Mangiafico, Carmela Spatafora

Publikováno v: Bioresource Technology. 99:5960-5966

On the basis of a preliminary screening of seven different samples of Sicilian grape pomace, the ‘Nerello Mascalese’ sample NM2 was selected for an ethanol preparative extraction. The defatted NM2 EtOH extract was subjected to DPPH and GAE assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030b6e090b166de4ddec360f3250fe68
https://doi.org/10.1016/j.biortech.2007.10.037

Synthesis of 3′(2′)-O-Lysophosphatidylnucleosides − a Further Application of a Chemoenzymatic Strategy

Autor: Danilo Aleo, Rosa Chillemi, Giuseppe Granata, Sebastiano Sciuto

Publikováno v: European Journal of Organic Chemistry. 2002:3622-3631

Mono[(2R)-2,3-dihydropropyl] esters of the four 3′-nucleotides of DNA, prepared from protected nucleoside phosphoramidites and [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol, were regioselectively acylated at the C-1 hydroxyl of the glycerol moiety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e0fdccecce3e83ef278cd4a6e3fce4d
https://doi.org/10.1002/1099-0690(200211)2002:21<3622::aid-ejoc3622>3.0.co

Oligonucleotides conjugated to natural lipids: synthesis of phosphatidyl-anchored antisense oligonucleotides

Autor: V. G. Nicoletti, Sebastiano Sciuto, Valentina Greco, Rosa Chillemi

Publikováno v: Bioconjugate chemistry. 24(4)

Antisense oligonucleotides are promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical in view of their clinical application. Despite the richness of synthetic strategies addressed to the lipophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02479dc1f7bd2671fec3e2c1383d9b52
https://pubmed.ncbi.nlm.nih.gov/23451795

Thermodynamic and NMR Study of Proton Complex Formation of 2′-Deoxyadenylyl-(3′→5′)-2′-Deoxyadenosine in Aqueous Solution

Autor: Vincenzo Cucinotta, Annalinda Contino, Rosa Chillemi, Sebastiano Sciuto

Publikováno v: Scopus-Elsevier

A thermodynamic and proton NMR study has been carried out in order to characterize the behaviour of 2′-deoxyadenylyl-(3′→5′)-2′-deoxyadenosine towards the protonation. Conformational changes occurring following two protonation steps are dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b717ff4be197973fc0c242988bbc95
https://doi.org/10.1080/15257779408011869