Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Rosa Caputo"'
2
Treatment of triple negative breast cancer (TNBC): current options and future perspectives
Autor: Daniela Cianniello, S. De Placido, Brigida Stanzione, Saverio Cinieri, M. De Laurentiis, Vito Lorusso, Rosa Caputo, Grazia Arpino
Publikováno v: Cancer Treatment Reviews. 36:S80-S86
Breast cancer is not considered anymore a unique disease. Microarray gene expression analysis led to the identification of 4 major breast cancer "intrinsic" subtypes, including hormone receptor (HR)-positive luminal A and B, human epidermal growth re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de39f99553ef6038dbf8226e0275881
https://doi.org/10.1016/s0305-7372(10)70025-6
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3
A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action
Autor: Ekambar R. Kandimalla, Sudhir Agrawal, Teresa Gelardi, Giampaolo Tortora, Vincenzo Damiano, Rosa Caputo, Luigi Racioppi, Corrado Garbi, Roberto Bianco, Sonia Garofalo, G. Merola, Roberta De Rosa
Publikováno v: Clinical Cancer Research. 15:6921-6930
Purpose: Resistance to anti-HER2 monoclonal antibody trastuzumab is a relevant issue in breast cancer patients. Among the mechanisms implicated in trastuzumab resistance, increasing evidence supports a role of tumor microenvironment. We previously fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1573371c4c58ee6fcdd5c40948577de8
https://doi.org/10.1158/1078-0432.ccr-09-1599
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4
Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs
Autor: Teresa Gelardi, Roberto Bianco, Vincenzo Damiano, Stefano Pepe, Fortunato Ciardiello, Gennaro Daniele, Michael Lahn, Giampaolo Tortora, Rosa Caputo
Publikováno v: British Journal of Cancer
We investigated the antitumour effect and ability to overcome the resistance to anti-EGFR drugs of enzastaurin, an inhibitor of VEGFR-dependent PKCbeta signalling. Enzastaurin was evaluated alone and in combination with the EGFR inhibitor gefitinib,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4c76a020735457163e35e46ad1737a
https://doi.org/10.1038/sj.bjc.6604493
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5
TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts
Autor: Sabino De Placido, Roberta De Rosa, Ekambar R. Kandimalla, Sudhir Agrawal, Sonia Garofalo, Fortunato Ciardiello, Giampaolo Tortora, Vincenzo Damiano, Rosa Caputo, Luigi Racioppi, G. Merola, Roberto Bianco, Teresa Gelardi, Gabriella Fontanini
Publikováno v: Proceedings of the National Academy of Sciences. 104:12468-12473
Synthetic agonists of Toll-like receptor 9 (TLR9), a class of agents that induce specific immune response, exhibit antitumor activity and are currently being investigated in cancer patients. Intriguingly, their mechanisms of action on tumor growth an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5f8917e75c4d48b73c65c0ef0c4eff
https://doi.org/10.1073/pnas.0705226104
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6
Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors
Autor: Sudhir Agrawal, Francesco Paolo D'Armiento, Vincenzo Damiano, Sabino De Placido, Antonio Leonardi, A. Raffaele Bianco, Fortunato Ciardiello, Giampaolo Tortora, Rosa Caputo, Roberto Bianco
Publikováno v: Clinical Cancer Research. 12:577-583
Purpose: Immunostimulating Toll-like receptor 9 (TLR9) agonists cause antitumor activity interfering also with cancer proliferation and angiogenesis by mechanisms still incompletely understood. We hypothesized that modified TLR9 agonists could impair
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95f11f2ef703252447acf5f703e0f41
https://doi.org/10.1158/1078-0432.ccr-05-1943
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7
Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma
Autor: Gabriella Fontanini, David Raben, Davide Melisi, Anderson J. Ryan, Sabino De Placido, Giampaolo Tortora, Roberto Bianco, Rosa Caputo, Fortunato Ciardiello, Vincenzo Damiano, Cataldo Bianco, A. Raffaele Bianco
Publikováno v: Clinical Cancer Research. 11:5639-5644
Purpose: Glioblastoma multiforme is an aggressive disease in which vascular endothelial growth factor (VEGF) and the EGF receptor (EGFR) are implicated in tumor growth, relapse, and resistance to radiotherapy and chemotherapy. The VEGF receptors VEGF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5cc058c959d43fa81e0a8ad8beca14
https://doi.org/10.1158/1078-0432.ccr-05-0174
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10
Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer
Autor: Davide Melisi, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora, Fortunato Ciardiello, Rosa Caputo, Bianca Maria Veneziani, Vincenzo Damiano, Roberto Bianco
Publikováno v: Endocrine-related cancer. 12(4)
Biphosphonates (BPs) are widely used to inhibit osteoclastic activity in malignant diseases such as bone metastatic breast and prostate carcinoma. Recent studies reported that BPs could also cause a direct antitumor effect, probably due to their abil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aa8242a668adfd149b2cfdf6c0701e
https://pubmed.ncbi.nlm.nih.gov/16322342
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