Výsledky vyhledávání - "Rosa Anna DeFilippis"

Akademický článek

Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics

Autor: Nancy Dumont, Bob Liu, Rosa Anna DeFilippis, Hang Chang, Joseph T. Rabban, Anthony N. Karnezis, Judy A. Tjoe, James Marx, Bahram Parvin, Thea D. Tlsty

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 3, Pp 249-262 (2013)

A wealth of evidence has now demonstrated that the microenvironment in which a tumorigenic cell evolves is as critical to its evolution as the genetic mutations it accrues. However, there is still relatively little known about how signals from the mi

Externí odkaz: https://doaj.org/article/ba9d2488c69d4b488322625cb0b2c810

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Supplementary Figures 1-8 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

Autor: Thea D. Tlsty, Bahram Parvin, Karla Kerlikowske, Maria Febbraio, Elad Ziv, Judy A. Tjoe, James J. Marx, Donglei Hu, Jianxin Zhao, Mona L. Gauthier, Hal K. Berman, Gerald V. Fontenay, Yunn-Yi Chen, Joseph T. Rabban, Nancy Dumont, Hang Chang, Rosa Anna DeFilippis

PDF file - 1.1MB, Figure S1: Image quantitation Figure S2: Histograms of Oil Red O quantitation in LDAFs and HDAFs Figure S3: Matrix protein immunofluorescent images of LDAFs and HDAFs Figure S4: Increased and decreased expression of CD36 in HMFs Fig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abc633ea446f50dfe5da12bebda0aaf
https://doi.org/10.1158/2159-8290.22529385.v1

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Supplementary Tables 1-9 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

PDF file - 392K, Tables S1, S2, S5, S6, S7 and S8: Patient information Table S3: LDAFs vs HDAFs microarray analysis Table S4: CD36 expression in published microarrays Table S9: Association of CD36 levels with tumor characteristics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cefea6cccbd7aabd014cbfe76b133c
https://doi.org/10.1158/2159-8290.22529379.v1

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Supplementary Figures Legends 1-8, Table Legends 1-9, Methods from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

PDF file - 131K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5905188d98788140576be1c08e186f3e
https://doi.org/10.1158/2159-8290.22529382.v1

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Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models

Autor: Raghuveer Singh Mali, Neil P. Shah, Qi Zhang, Edna F. Choo, Jayant Raman, Vinitha Mary Kuruvilla, Elisabeth A. Lasater, Monique Dail, Marina Konopleva, Rosa Anna DeFilippis, Antonio Cavazos, Vidhi Mody, Deepak Sampath

Publikováno v: Haematologica

FLT3 internal tandem duplication (FLT3-ITD) mutations account for ~25% of adult acute myeloid leukemia cases and are associated with poor prognosis. Venetoclax, a selective BCL-2 inhibitor, has limited monotherapy activity in relapsed/refractory acut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ecaac07d56ded47e2945dd25cf2270
https://pubmed.ncbi.nlm.nih.gov/32414851

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Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

Publikováno v: Cancer discovery. 9(8)

Gilteritinib is a potent and selective FLT3 kinase inhibitor with single-agent clinical efficacy in relapsed/refractory FLT3-mutated acute myeloid leukemia (AML). In this context, however, gilteritinib is not curative, and response duration is limite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b58f7de85fef24c4cc84e4d0b9d7ec7
https://pubmed.ncbi.nlm.nih.gov/31371322

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Stress Signaling from Human Mammary Epithelial Cells Contributes to Phenotypes of Mammographic Density

Autor: Rosa Anna DeFilippis, Gerald V. Fontenay, Jianxin Zhao, Bahram Parvin, Thea D. Tlsty, Karla Kerlikowske, Kelley T. Patten, Hang Chang, Colleen A. Fordyce

Publikováno v: Cancer Research. 74:5032-5044

Telomere malfunction and other types of DNA damage induce an activin A–dependent stress response in mortal nontumorigenic human mammary epithelial cells that subsequently induces desmoplastic-like phenotypes in neighboring fibroblasts. Some charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075d8ac7df197794874856ff8198d5bb
https://doi.org/10.1158/0008-5472.can-13-3390

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Graphical methods for quantifying macromolecules through bright field imaging

Autor: Rosa Anna DeFilippis, Bahram Parvin, Hang Chang, Thea D. Tlsty

Publikováno v: Bioinformatics

Bright field imaging of biological samples stained with antibodies and/or special stains provides a rapid protocol for visualizing various macromolecules. However, this method of sample staining and imaging is rarely employed for direct quantitative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a0dce13d90cf2d80a1c2c4abe25039
http://europepmc.org/articles/PMC2666809

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Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma Cells

Autor: Lingling Wu, Edward C. Goodwin, Daniel DiMaio, Rosa Anna DeFilippis

Publikováno v: Journal of Virology. 77:1551-1563

Cervical cancer cells express high-risk human papillomavirus (HPV) E6 and E7 proteins, and repression of HPV gene expression causes the cells to cease proliferation and undergo senescence. However, it is not known whether both HPV proteins are requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6213a6721d51f191f5e2891b120e9c84
https://doi.org/10.1128/jvi.77.2.1551-1563.2003

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Hello out there...is anybody listening?

Autor: Rosa Anna DeFilippis, Thea D. Tlsty

Publikováno v: Cancer discovery. 2(12)

Breast cancer recurrence rates vary following treatment, suggesting that tumor cells disseminate early from primary sites but remain indolent indefinitely before progressing to symptomatic disease. The reasons why some indolent disseminated tumors er

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5c653451b9fde1cb08c77108df19a5
https://pubmed.ncbi.nlm.nih.gov/22896036

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