PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes

Autor: Jesús Ogando, María Eugenia Sáez, Javier Santos, Cristina Nuevo-Tapioles, Marta Gut, Anna Esteve-Codina, Simon Heath, Antonio González-Pérez, José M. Cuezva, Rosa Ana Lacalle, Santos Mañes

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)

Abstract Background Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer treatment, yet the inhib

Externí odkaz: https://doaj.org/article/bf07bf307d7e439992d5b6c5761a4ede

A flow cytometry-based method to screen for modulators of tumor-specific T cell cytotoxicity

Autor: Javier, Santos, Jesús, Ogando, Rosa Ana, Lacalle, Santos, Mañes

Publikováno v: Methods in enzymology. 631

Cancer immunotherapy relies on the ability of immune cells to kill malignant cells. The cytotoxic T lymphocyte (CTL) response is perhaps the functional measure that best reflects cell-mediated immunity against cancer. Straightforward methods that fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e33eab4f4c89749fccf2ae3f41332d4c
https://pubmed.ncbi.nlm.nih.gov/31948564

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

Autor: Manuel Tardaguila, Emilia Mira, María Jesús Fernández-Aceñero, Tim D. Oury, Ignacio Heras-Murillo, Rosa Ana Lacalle, Eduardo Díaz-Rubio, Silvia Martin-Puig, Paula Martin-Gonzalez, Beatriz Perez-Villamil, Lorena Carmona-Rodríguez, Santos Mañes, Mateo Paz-Cabezas, Diego Martínez-Rey, Josefina Casas, Gemma Fabriàs

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

One drawback of chemotherapy is poor drug delivery to tumor cells, due in part to hyperpermeability of the tumor vasculature. Extracellular superoxide dismutase (SOD3) is an antioxidant enzyme usually repressed in the tumor milieu. Here we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5251749380f7338ecfb962e7f34e954
http://hdl.handle.net/10261/173892

Type I phosphatidylinositol 4‐phosphate 5‐kinase homo‐ and heterodimerization determines its membrane localization and activity

Autor: Mario Mellado, Juan C. de Karam, Félix M. Goñi, Rosa Ana Lacalle, Ibai Artetxe, Jesús Sot, Ana M. Rojas, Laura Martínez-Muñoz, Rosa M. Peregil, Santos Mañes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Type I phosphatidylinositol 4-phosphate 5-kinases (PIP5KIs; α, β, and γ) are a family of isoenzymes that produce phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] using phosphatidylinositol 4-phosphate as substrate. Their structural homology with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac3d402ebf7680ff1f1b8a27732f41e
https://doi.org/10.1096/fj.14-264606

Orchestration of lymphocyte chemotaxis by mitochondrial dynamics

Autor: Luca Scorrano, Antonella Viola, Silvia Campello, Monica Bettella, Santos Mañes, Rosa Ana Lacalle

Publikováno v: The Journal of Experimental Medicine

Lymphocyte traffic is required to maintain homeostasis and perform appropriate immunological reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial and functional asymmetries. Mitochondria are highly dynamic organelles that dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c31e777ff3f1fdd262d3a4fe777c8d
http://europepmc.org/articles/PMC2118173