Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rosa A. Gonzalez-Polo"'
Autor:
Eva Alegre-Cortés, Alicia Muriel-González, Saray Canales-Cortés, Elisabet Uribe-Carretero, Guadalupe Martínez-Chacón, Ana Aiastui, Adolfo López de Munain, Mireia Niso-Santano, Rosa A. Gonzalez-Polo, José M. Fuentes, Sokhna M. S. Yakhine-Diop
Publikováno v:
Antioxidants, Vol 9, Iss 6, p 524 (2020)
Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. This neuronal loss, inherent to age, is related to exposure to environmental toxins and/or a g
Externí odkaz:
https://doaj.org/article/6e53fef3a6924a62ab14c3353d974cab
Autor:
Guadalupe, Martínez-Chacón, Marta, Paredes-Barquero, Sokhna M S, Yakhine-Diop, Elisabet, Uribe-Carretero, Ariadna, Bargiela, María, Sabater-Arcis, José, Morales-García, Jesús, Alarcón-Gil, Eva, Alegre-Cortés, Saray, Canales-Cortés, Mario, Rodríguez-Arribas, Pedro Javier, Camello, José Manuel Bravo-San, Pedro, Ana, Perez-Castillo, Rubén, Artero, Rosa A, Gonzalez-Polo, José M, Fuentes, Mireia, Niso-Santano
Publikováno v:
Cell biology and toxicology.
Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75c87bc5b5cdb005c7e0990086f3ccca
https://pubmed.ncbi.nlm.nih.gov/34448959
https://pubmed.ncbi.nlm.nih.gov/34448959
Autor:
Guido Kroemer, Jean Feuillard, Didier Decaudin, Martine Raphael, Claire Fabre, Gabrielle Carvalho, Mojgan Djavaheri-Mergny, Nathanael Larochette, Thorsten Braun, Ibtissam Youlyouz-Marfak, Rosa-Ana Gonzalez-Polo, Patrice Codogno, Jean-Luc Perfettini
Publikováno v:
Oncogene. 24:7503-7513
1-(2-Chlorophenyl-N-methylpropyl)-3-isoquinolinecarboxamide (PK11195) is a prototypic ligand of the peripheral benzodiazepine receptor (PBR), a mitochondrial outer membrane protein. PK11195 can be used to chemosensitize tumor cells to a variety of ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21510fa5d5d7c9737e779dbc802a5965
https://doi.org/10.1038/sj.onc.1208907
https://doi.org/10.1038/sj.onc.1208907
Autor:
Eeva-Liisa Eskelinen, Paul Saftig, Abdelali Jalil, Anne-Laure Pauleau, Gérard Pierron, Rosa-Ana Gonzalez-Polo, Nathanael Larochette, Guido Kroemer, Sylvie Souquère, Patricia Boya
Publikováno v:
Journal of Cell Science. 118:3091-3102
Autophagic cell death is morphologically characterized by an accumulation of autophagic vacuoles. Here, we show that inactivation of LAMP2 by RNA interference or by homologous recombination leads to autophagic vacuolization in nutrient-depleted cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4685bcd0c1079153542696c4ecbc1cb
https://doi.org/10.1242/jcs.02447
https://doi.org/10.1242/jcs.02447
Autor:
Thomas Roumier, Jean-Luc Perfettini, Helena L. A. Vieira, Rosa-Ana Gonzalez-Polo, Delphine Poncet, Guido Kroemer, Karine Andreau, Patricia Boya
Publikováno v:
Oncogene. 22:3927-3936
Hydroxychloroquine (HCQ) is a lysosomotropic amine with cytotoxic properties. Here, we show that HCQ induces signs of lysosomal membrane permeabilization (LMP), such as the decrease in the lysosomal pH gradient and the release of cathepsin B from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2c6a5a171d74d32fa0b62a19deb01f
https://doi.org/10.1038/sj.onc.1206622
https://doi.org/10.1038/sj.onc.1206622
Autor:
Mercedes Blanco-Benítez, Ana Calderón-Fernández, Saray Canales-Cortés, Eva Alegre-Cortés, Elisabet Uribe-Carretero, Marta Paredes-Barquero, Alberto Gimenez-Bejarano, Gema Duque González, Patricia Gómez-Suaga, Juan Ortega-Vidal, Sofía Salido, Joaquín Altarejos, Guadalupe Martínez-Chacón, Mireia Niso-Santano, José M. Fuentes, Rosa A. González-Polo, Sokhna M. S. Yakhine-Diop
Publikováno v:
Molecular & Cellular Oncology, Vol 9, Iss 1 (2022)
Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in oxidative ca
Externí odkaz:
https://doaj.org/article/9687ece4146f48c7af61cb3d204be370
Autor:
Yaiza Corral Nieto, Sokhna M. S. Yakhine-Diop, Paula Moreno-Cruz, Laura Manrique García, Amanda Gabrielly Pereira, José A. Morales-García, Mireia Niso-Santano, Rosa A. González-Polo, Elisabet Uribe-Carretero, Sylvère Durand, Maria Chiara Maiuri, Marta Paredes-Barquero, Eva Alegre-Cortés, Saray Canales-Cortés, Adolfo López de Munain, Jordi Pérez-Tur, Ana Pérez-Castillo, Guido Kroemer, José M. Fuentes, José M. Bravo-San Pedro
Publikováno v:
Cells, Vol 12, Iss 5, p 806 (2023)
The identification of Parkinson’s disease (PD) biomarkers has become a main goal for the diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to neurological problems, but also to a series of alterations in perip
Externí odkaz:
https://doaj.org/article/917e21376071483687b2b7925531f170
Autor:
Noelia Casares, Guido Kroemer, Patricia Boya, Tamotsu Yoshimori, Rosa-Ana Gonzalez-Polo, Patrice Codogno, Daniel Meley, Sylvie Souquère, Gérard Pierron, Nathanael Larochette, Philippe Dessen, Didier Métivier, Jean-Luc Perfettini
Mammalian cells were observed to die under conditions in which nutrients were depleted and, simultaneously, macroautophagy was inhibited either genetically (by a small interfering RNA targeting Atg5, Atg6/Beclin 1-1, Atg10, or Atg12) or pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be19d408b1aab22a77f760d60297c251
https://europepmc.org/articles/PMC543994/
https://europepmc.org/articles/PMC543994/
Autor:
Naoufal Zamzami, Delphine Poncet, Rosa-Ana Gonzalez-Polo, Anne-Laure Pauleau, Patricia Boya, Guido Kroemer
Publikováno v:
Biochimica et biophysica acta. 1659(2-3)
Mitochondrial membrane permeabilization (MMP) is a critical step regulating apoptosis. Viruses have evolved multiple strategies to modulate apoptosis for their own benefit. Thus, many viruses code for proteins that act on mitochondria and control apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e2d6e677cbfc796b6516d02f35a5eb
https://pubmed.ncbi.nlm.nih.gov/15576050
https://pubmed.ncbi.nlm.nih.gov/15576050
Autor:
Guido Kroemer, Nathanael Larochette, Jean-Luc Perfettini, Aintzane Asumendi, Rosa-Ana Gonzalez-Polo, Patricia Boya, Catherine Brenner, Remy Fagard, Martine Raphael, Aurélien Deniaud, Fanny Baran-Marszak, Jean Feuillard, Bernard Pau, Isabelle Gourdier, Maria Celia Morales, Karine Andreau
Publikováno v:
Oncogene. 22(40)
N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a potent chemopreventive agent whose effect has been suggested to involve apoptosis induction. 4-HPR induces a loss of the mitochondrial transmembrane potential and the mitochondrial release of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65af22a32077c24549b92eb29a3d1cf2
https://pubmed.ncbi.nlm.nih.gov/13679861
https://pubmed.ncbi.nlm.nih.gov/13679861