Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rosa, Scala"'
Autor:
Rosa Scala, Fatima Maqoud, Marina Antonacci, Jacopo Raffaele Dibenedetto, Maria Grazia Perrone, Antonio Scilimati, Karen Castillo, Ramón Latorre, Diana Conte, Saïd Bendahhou, Domenico Tricarico
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Bisphosphonates (BPs) are the most used bone-specific anti-resorptive agents, often chosen as first-line therapy in several bone diseases characterized by an imbalance between osteoblast-mediated bone production and osteoclast-mediated bone resorptio
Externí odkaz:
https://doaj.org/article/6a7e62c742264dd39d93dba1e6bff02b
Autor:
Rosa Scala, Fatima Maqoud, Conor McClenaghan, Theresa M. Harter, Maria Grazia Perrone, Antonio Scilimati, Colin G. Nichols, Domenico Tricarico
Publikováno v:
Cells, Vol 12, Iss 6, p 928 (2023)
Cantú syndrome (CS) is caused by the gain of function mutations in the ABCC9 and KCNJ8 genes encoding, respectively, for the sulfonylureas receptor type 2 (SUR2) and the inwardly rectifier potassium channel 6.1 (Kir6.1) of the ATP-sensitive potassiu
Externí odkaz:
https://doaj.org/article/6ee79164735747b6aa9bf1c7ad8fb9db
Autor:
Charline Fagnen, Ludovic Bannwarth, Dania Zuniga, Iman Oubella, Rita De Zorzi, Eric Forest, Rosa Scala, Samuel Guilbault, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open conf
Externí odkaz:
https://doaj.org/article/ef606afc0a8f4ef69edb9105d4e9fe2c
Autor:
Rosa Scala, Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Giulia Maria Camerino, Francesco Alfredo Zito, Girolamo Ranieri, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Cantù syndrome (CS) arises from mutations in ABCC9 and KCNJ8 genes that lead to gain of function (GOF) of ATP-sensitive potassium (KATP) channels containing SUR2A and Kir6.1 subunits, respectively, of KATP channels. Pathological consequences of CS h
Externí odkaz:
https://doaj.org/article/5c7ee5dad2c14dfc898790e7ecfcfa53
Autor:
Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Nunzio Denora, Giuseppe Passantino, Rosa Scala, Annalisa Cutrignelli, Antonella Tinelli, Valentino Laquintana, Flavia laForgia, Sergio Fontana, Massimo Franco, Angela Assunta Lopedota, Domenico Tricarico
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract The efficacy of minoxidil (MXD) ethanolic solutions (1%‐5% w/v) in the treatment of androgenetic alopecia is limited by adverse reactions. The toxicological effects of repeated topical applications of escalating dose (0.035%‐3.5% w/v) an
Externí odkaz:
https://doaj.org/article/2b598d239ed24be79ab832f29cc8f374
Autor:
Fatima Maqoud, Rosa Scala, Vincenzo Tragni, Ciro Leonardo Pierri, Maria Grazia Perrone, Antonio Scilimati, Domenico Tricarico
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1350 (2021)
Zoledronic acid (ZOL) is used as a bone-specific antiresorptive drug with antimyeloma effects. Adverse drug reactions (A.D.R.) are associated with ZOL-therapy, whose mechanics are unknown. ZOL is a nitrogen-containing molecule whose structure shows s
Externí odkaz:
https://doaj.org/article/3a8188d12637448b97ddb88fa32062c8
Autor:
Rosa Scala, Fatima Maqoud, Nicola Zizzo, Giuseppe Passantino, Antonietta Mele, Giulia Maria Camerino, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico
Publikováno v:
Cells, Vol 10, Iss 7, p 1791 (2021)
(1) Background: Cantu syndrome (CS) arises from gain-of-function (GOF) mutations in the ABCC9 and KCNJ8 genes, which encode ATP-sensitive K+ (KATP) channel subunits SUR2 and Kir6.1, respectively. Most CS patients have mutations in SUR2, the major com
Externí odkaz:
https://doaj.org/article/285fd30aa5364e8a9e76224eb4ad1228
Autor:
Nicola Zizzo, Giuseppe Passantino, Roberta Maria D'alessio, Antonella Tinelli, Giuseppe Lopresti, Rosa Patruno, Domenico Tricarico, Fatima Maqoud, Rosa Scala, Francesco Alfredo Zito, Girolamo Ranieri
Publikováno v:
Frontiers in Veterinary Science, Vol 6 (2019)
Purpose: The thymidine phosphorylase (TP) is a key enzyme involved in the metabolism of pyrimidines. Inhibition or downregulation of this enzyme causes accumulation of metabolites with consequences in DNA replication. TP regulates angiogenesis and ch
Externí odkaz:
https://doaj.org/article/9b5ae6ac721c4feaa0ef7139b5011c83
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 21:130-149
Arachidonic acids and its metabolites modulate plenty of ligand-gated, voltage-dependent ion channels, and metabolically regulated potassium channels including ATP-sensitive potassium channels (KATP). KATP channels are hetero-multimeric complexes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e68910a045f058fcf5762ac130e1cb
https://doi.org/10.2174/1871527320666210119095626
https://doi.org/10.2174/1871527320666210119095626
Autor:
Carlos A. H. Fernandes, Dania Zuniga, Charline Fagnen, Valérie Kugler, Rosa Scala, Gérard Péhau-Arnaudet, Renaud Wagner, David Perahia, Saïd Bendahhou, Catherine Vénien-Bryan
Publikováno v:
Science Advances
Science Advances, 2022, 8 (38), ⟨10.1126/sciadv.abq8489⟩
Science Advances, 2022, 8 (38), ⟨10.1126/sciadv.abq8489⟩
We present the first structure of the human Kir2.1 channel containing both transmembrane domain (TMD) and cytoplasmic domain (CTD). Kir2.1 channels are strongly inward-rectifying potassium channels that play a key role in maintaining resting membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49e7b89a9fc58bd0f49b5c51be4af22
https://hal.sorbonne-universite.fr/hal-03946508/document
https://hal.sorbonne-universite.fr/hal-03946508/document
