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Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder

Autor: Flavia Venetucci Gouveia, Jürgen Germann, Gabriel A. Devenyi, Rosa M. C. B. Morais, Ana Paula M. Santos, Erich T. Fonoff, Clement Hamani, Helena Brentani, M. Mallar Chakravarty, Raquel C. R. Martinez

Publikováno v: BJPsych Open, Vol 6 (2020)

Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated

Externí odkaz: https://doaj.org/article/fbd2039130c74d1a9d6bf87aef52fafc

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Autor: Anthony D. Garcia, Kim T. Tran, Lars Jakobsen Høj, Jakob S. Pallesen, Tommy N. Johansen, Giuseppe Marseglia, Michael Gajhede, Federico Munafò, Michael Sattler, Grzegorz M Popowicz, Haritha L. Desu, Dilip Narayanan, Sara Marie Øie Solbak, Anders Bach, Louis M.E. Sørensen, Rosa M. C. Carmona, Roberta Brambilla

Publikováno v: Pallesen, J S, Narayanan, D, Tran, K T, Solbak, S M Ø, Marseglia, G, Sørensen, L M E, Høj, L J, Munafò, F, Carmona, R M C, Garcia, A D, Desu, H L, Brambilla, R, Johansen, T N, Popowicz, G M, Sattler, M, Gajhede, M & Bach, A 2021, ' Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds ', Journal of Medicinal Chemistry, vol. 64, no. 8, pp. 4623-4661 . https://doi.org/10.1021/acs.jmedchem.0c02094
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
J. Med. Chem. 64, 4623-4661 (2021)
Journal of Medicinal Chemistry, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
Pallesen, J S, Narayanan, D, Tran, K T, Solbak, S M Ø, Marseglia, G, Sørensen, L M E, Høj, L J, Munafò, F, Carmona, R M C, Garcia, A D, Desu, H L, Brambilla, R, Johansen, T N, Popowicz, G M, Sattler, M, Gajhede, M & Bach, A 2021, ' Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds ', Journal of Medicinal Chemistry, vol. 64, no. 8, pp. 4623–4661 . https://doi.org/10.1021/acs.jmedchem.0c02094

Targeting the protein–protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be38b6b6fe59378aedc77f3f260f9ff0
https://pubmed.ncbi.nlm.nih.gov/33818106

Clonagem e expressão de quimera contendo a proteína ROP2 de Neospora caninum fusionada a lipoproteína OprI de Pseudomonas aeruginosa

Autor: ROSA. M. C. DA, SANTOS, F. D. S., CONRAD, N. L., PIRAINE, R. E. A., GONÇALVES, V. S., CUNHA, R. C., ANDREOTTI, R.

Publikováno v: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA

Made available in DSpace on 2021-07-09T02:19:53Z (GMT). No. of bitstreams: 1 Matheus-BJD.pdf: 271500 bytes, checksum: 63243c674bb9c01014d1e06e3da973d6 (MD5) Previous issue date: 2021

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::bb3bc964c207970f18e64b11b2641091
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1132882