Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rosa, Cookson"'
Autor:
Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White
Publikováno v:
Journal of Medicinal Chemistry. 65:15174-15207
The bromodomain and extra terminal (BET) family of proteins are an integral part of human epigenome regulation, the dysregulation of which is implicated in multiple oncology and inflammatory diseases. Disrupting the BET family bromodomain acetyl-lysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c403b556d0cdc2a89bb75345904c1
https://doi.org/10.1021/acs.jmedchem.2c01102
https://doi.org/10.1021/acs.jmedchem.2c01102
Autor:
Rosa Cookson, Aini Vuorinen, Jonathan Pettinger, Cassandra R. Kennedy, Joanna M. Kirkpatrick, Rachel E. Peltier-Heap, Andrew Powell, Ambrosius P. Snijders, Mark Skehel, David House, Katrin Rittinger, Jacob T. Bush
SummaryChemoproteomics is a powerful method capable of detecting interactions between small molecules and the proteome, however its use as a high-throughput screening method for chemical libraries has so far been limited. To address this need, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff8aafd003a34329baeafd8d02f1023
https://doi.org/10.1101/2023.02.01.526632
https://doi.org/10.1101/2023.02.01.526632
Autor:
Christopher A Natale, Elizabeth K Duperret, Junqian Zhang, Rochelle Sadeghi, Ankit Dahal, Kevin Tyler O'Brien, Rosa Cookson, Jeffrey D Winkler, Todd W Ridky
Publikováno v:
eLife, Vol 5 (2016)
The association between pregnancy and altered cutaneous pigmentation has been documented for over two millennia, suggesting that sex hormones play a role in regulating epidermal melanocyte (MC) homeostasis. Here we show that physiologic estrogen (17
Externí odkaz:
https://doaj.org/article/5a94f997ed32420a82a0f13011bcb7fa
Autor:
Véronique Gouverneur, David C. Blakemore, Maxime Ghosez, Patrick G. Isenegger, Natan J. W. Straathof, Rosa Cookson, Paul G. Richardson, Robert Szpera
Publikováno v:
Organic Letters
Herein, we report a highly effective protocol for the cross-coupling of (hetero)aryl bromides with fluorinated alcohols using the commercially available precatalyst tBuBrettPhos Pd G3 and Cs2CO3 in toluene. This Pd-catalyzed coupling features a short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dce21552554ed845a46a7a5647b211
https://doi.org/10.1021/acs.orglett.0c02347
https://doi.org/10.1021/acs.orglett.0c02347
Autor:
Harley Green, Lydia Barnes, Jolyon Matthews-Wright, Rachel Szpara, Luke Francis, Nuria S. Lima, Hollie Blaber, Carrie K. W. Wong, Alexander Seal, Charlotte S. Payne, Matthew F. Meehan, C. Elizabeth Killalea, Rohan J. Trainor, Katherine Wood, Jack M. J. Grace, Oliver Williams, Liam Cochrane, Edmund J. P. Hogarth, Katherine Louise Jones, Zoe J. Lee, Shusha Mahdy, Anna Gruszka, Lisa Morrison, Freya Taday, Leyla Jusu, Oliver King, May-Li Mackinnon, Joe Stillibrand, Daniel Buckley, Edward Cooney, Z.A. Henley, Simon J. F. Macdonald, Christina L. Long, Daniel Fu He, Craig Pike, Zoe C. Byron, Keenan M. Smith, Ian Edward David Smith, Antony M. Threadgould, Lewis Byers, Kamile Stanelyte, Hal R. I. Parke, Nick Barton, Rosa Cookson, James E. Rowedder, Andrew Nortcliffe, Aaron J. Senior, Alan Nadin, Makenzie J. Millward, Joseph Lambert, Lawrence Payne, David T. K. Brooks, Christopher Merrett, Heather A. Damian, Jordan Waters, Richard G. Chilvers
Publikováno v:
Journal of Medicinal Chemistry. 62:10402-10422
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c565e07f6df53b788d687eb5d9b250
https://doi.org/10.1021/acs.jmedchem.9b01499
https://doi.org/10.1021/acs.jmedchem.9b01499
Autor:
Lydia, Barnes, Hollie, Blaber, David T K, Brooks, Lewis, Byers, Daniel, Buckley, Zoe C, Byron, Richard G, Chilvers, Liam, Cochrane, Edward, Cooney, Heather A, Damian, Luke, Francis, Daniel, Fu He, Jack M J, Grace, Harley J, Green, Edmund J P, Hogarth, Leyla, Jusu, C Elizabeth, Killalea, Oliver, King, Joseph, Lambert, Zoe J, Lee, Nuria S, Lima, Christina L, Long, May-Li, Mackinnon, Shusha, Mahdy, Jolyon, Matthews-Wright, Makenzie J, Millward, Matthew F, Meehan, Christopher, Merrett, Lisa, Morrison, Hal R I, Parke, Charlotte, Payne, Lawrence, Payne, Craig, Pike, Alexander, Seal, Aaron J, Senior, Keenan M, Smith, Kamile, Stanelyte, Joe, Stillibrand, Rachel, Szpara, Freya F H, Taday, Antony M, Threadgould, Rohan J, Trainor, Jordan, Waters, Oliver, Williams, Carrie K W, Wong, Katherine, Wood, Nick, Barton, Anna, Gruszka, Zoe, Henley, James E, Rowedder, Rosa, Cookson, Katherine L, Jones, Alan, Nadin, Ian E, Smith, Simon J F, Macdonald, Andrew, Nortcliffe
Publikováno v:
Journal of medicinal chemistry. 62(22)
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the thienopyrimidine scaffold, we have identified a liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fdc25e5b8f8a8c4bddd4753118b0c5e
https://pubmed.ncbi.nlm.nih.gov/31647659
https://pubmed.ncbi.nlm.nih.gov/31647659
Autor:
Philip J. Parsons, Daniel C. Elliott, Tsz-Kan Ma, Rosa Cookson, Aymane Selmani, Anthony G. M. Barrett
Publikováno v:
Organic Letters. 18:1800-1803
Trapping of the ketene generated from the thermolysis of 2-methyl-2-phenyl-1,3-dioxane-4,6-dione-keto-dioxinone at 50 °C with primary, secondary, or tertiary alcohols gave the corresponding dioxinone β-keto-esters in good yield under neutral condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c6dad626407663ca1c4a013854e83c
https://doi.org/10.1021/acs.orglett.6b00533
https://doi.org/10.1021/acs.orglett.6b00533
Publikováno v:
European Journal of Organic Chemistry. 2014:4523-4535
Studies towards the total synthesis of the natural product radicicol are described that employ a late-stage esterification and aromatization by trapping a ketene intermediate. The subsequent biomimetic aromatization of the resultant triketo ester gav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d6c5c31d8870cc9782ef3d2496386a
https://doi.org/10.1002/ejoc.201402205
https://doi.org/10.1002/ejoc.201402205
Autor:
Rosa Cookson, Philip J. Parsons, Daniel C. Elliott, Aymane Selmani, Anthony G. M. Barrett, Tsz-Kan Ma
Publikováno v:
ChemInform. 47
Trapping of the ketene generated from the thermolysis of 2-methyl-2-phenyl-1,3-dioxane-4,6-dione-keto-dioxinone at 50 °C with primary, secondary, or tertiary alcohols gave the corresponding dioxinone β-keto-esters in good yield under neutral condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32fe28c4ba4441f85fd2b6fe02197ba8
https://doi.org/10.1002/chin.201633161
https://doi.org/10.1002/chin.201633161
Autor:
Elizabeth K. Duperret, Junqian Zhang, Jeffrey D. Winkler, Todd W. Ridky, Ankit Dahal, Kevin O'Brien, Rochelle Sadeghi, Rosa Cookson, Christopher A. Natale
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
The association between pregnancy and altered cutaneous pigmentation has been documented for over two millennia, suggesting that sex hormones play a role in regulating epidermal melanocyte (MC) homeostasis. Here we show that physiologic estrogen (17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080b9d7e26d3574c9380065431ec5439
https://doi.org/10.7554/elife.15104
https://doi.org/10.7554/elife.15104