Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rory W. Blackler"'
Autor:
Giada De Palma, Rory W. Blackler, Gabriela Jorge Da Silva, Michael G. Surette, Kyle L. Flannigan, Anna Manko, Premysl Bercik, Andre G. Buret, John L. Wallace
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G994-G1003
The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria, and enterohepatic circulatio
Autor:
Premysl Bercik, Michael G. Surette, Matthew L. Workentine, Jean-Paul Motta, Anna Manko, Rory W. Blackler, John L. Wallace
Publikováno v:
British Journal of Pharmacology. 172:992-1004
Background and Purpose Hydrogen sulphide is an important mediator of gastrointestinal mucosal defence. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is significantly limited by their toxicity in the gastrointestinal tract. Particularly co
Autor:
Jose G. Ferraz, John L. Wallace, Kyle L. Flannigan, Rory W. Blackler, Terence A. Agbor, Waliul I. Khan, Janice J. Kim, Elena F. Verdu
Publikováno v:
Proceedings of the National Academy of Sciences. 111:13559-13564
Vitamin B deficiencies, which can lead to hyperhomocysteinemia (Hhcy), are commonly reported in patients with inflammatory bowel disease (IBD) and may be a causative underlying factor. However, the mechanism for this effect is not known. Hydrogen sul
Autor:
Iulia Gamaniek, Rory W. Blackler, Kyle L. Flannigan, Gabriela Jorge Da Silva, Andre G. Buret, John L. Wallace, Lu Wang, Jean-Paul Motta, Melissa V. Chan, Anna Manko, Wagdi Elsheikh
Significance: There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair. There is also growing evidence that H2S can be successfully exploite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84239341b2ab62298682e9c0a72f4a8a
Autor:
Jennifer K. Beatty, Kyle L. Flannigan, Gabriela Jorge Da Silva, Matthew L. Workentine, Andre G. Buret, Rory W. Blackler, Rui Wang, Terence A. Agbor, Jean-Paul Motta, John L. Wallace
Publikováno v:
Inflammatory bowel diseases. 21(5)
Microbiota dysbiosis and impaired barrier function are among the most prominent features of inflammatory bowel disease. In the gastrointestinal tract, hydrogen sulfide (H(2)S) is an important regulator of mucosal homeostasis. We hypothesized that H(2
Autor:
Stephanie D. Syer, Anne Aucouturier, Michael G. Surette, Giada De Palma, Premek Bercik, Philippe Langella, John L. Wallace, Rory W. Blackler, Elena F. Verdu, Rebeca Martín, Laura Rossi
Publikováno v:
Journal of Gastroenterology
Journal of Gastroenterology, Springer Verlag, 2015, 50 (4), pp.387-393. ⟨10.1007/s00535-014-1032-1⟩
Journal of Gastroenterology, Springer Verlag, 2015, 50 (4), pp.387-393. ⟨10.1007/s00535-014-1032-1⟩
The clinical significance of small intestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains under-appreciated. It occurs with greater frequency than the damage caused by these drugs in the upper gastrointestinal tract, but is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4283bb34cd33d96144542d92907b40b
https://hal.archives-ouvertes.fr/hal-01536449
https://hal.archives-ouvertes.fr/hal-01536449
Autor:
Rory W, Blackler, Jean-Paul, Motta, Anna, Manko, Matthew, Workentine, Premysl, Bercik, Michael G, Surette, John L, Wallace
Publikováno v:
British journal of pharmacology. 172(4)
Hydrogen sulphide is an important mediator of gastrointestinal mucosal defence. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is significantly limited by their toxicity in the gastrointestinal tract. Particularly concerning is the lack of
Publikováno v:
Current opinion in pharmacology. 19
Nonsteroidal anti-inflammatory drugs (NSAIDs) remain among the most commonly used medications because of their effectiveness in reducing pain and inflammation. Inhibitors of gastric acid secretion can substantially reduce the damaging effects of NSAI
Autor:
Jean-Paul Motta, Rory W. Blackler, Andre G. Buret, Terence A. Agbor, Matt Workentine, John L. Wallace, Gabriela Jorge Da Silva, Kyle L. Flannigan
Publikováno v:
The FASEB Journal. 28
We hypothesised that hydrogen sulfide (H2S) modifies gut microbiota and resolves intestinal inflammation. Rats were gavaged with diallyl disulfide (DADs), and colitis was induced by dinitrobenzene sulfonic acid (DNBS). Colitis severity was assessed b
Publikováno v:
Nitric Oxide. 27:S15
Background The gastrointestinal (GI) ulceration and bleeding caused by non-steroidal anti-inflammatory drugs (NSAIDs) is particularly prevalent in older patients with various co-morbidities. Hydrogen sulfide (H2S) has been shown to increase mucosal r