Výsledky vyhledávání - "Rory Pritchard"

Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A

Autor: Linda S. Sorkin, Fred J. Koehrn, Adam R. Ferguson, John H. Weiss, Richard L. Huganir, Wen Hua Xiao, Mathias Leinders, Rory Pritchard, Gary J. Bennett, Gustaf Wigerblad, Camilla I. Svensson, J.R. Huie, Hong Zhen Yin

Publikováno v: Experimental Neurology. 293:144-158

Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca2+ permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e0610c4b3ffff592724c936c9d10d5
https://doi.org/10.1016/j.expneurol.2017.04.004

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Photoperiod-induced neurotransmitter plasticity declines with aging: An epigenetic regulation?

Autor: Rory Pritchard, Davide Dulcis, Ben Romoli, Nicholas C. Spitzer, Helene Chen

Publikováno v: The Journal of comparative neurology, vol 528, iss 2

Neuroplasticity has classically been understood to arise through changes in synaptic strength or synaptic connectivity. A newly discovered form of neuroplasticity, neurotransmitter switching, involves changes in neurotransmitter identity. Chronic exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ef39a907639564c872d73bd13bb219
https://pubmed.ncbi.nlm.nih.gov/31343079

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Increased miR-132-3p expression is associated with chronic neuropathic pain

Autor: Claudia Sommer, Rory Pritchard, Nurcan Üçeyler, Mathias Leinders, Linda S. Sorkin

Publikováno v: Experimental neurology, vol 283, iss Pt A

Alterations in the neuro-immune balance play a major role in the pathophysiology of chronic neuropathic pain. MicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and mainte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73790722a6daa7ab5fec653b0b7ece83
https://doi.org/10.1016/j.expneurol.2016.06.025

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Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation

Autor: Rory Pritchard, Linda S. Sorkin, Mathilda Larsson, Mathias Leinders, Lovissa Falk

Publikováno v: Pain

PI3K-α, -δ, and -γ all participate in inflammation induction. Antagonism of only PI3K-γ blocks nociception, which is indicative of a role for this isoform within the afferent.
Phosphoinositide 3-kinases (PI3Ks) participate in signal transduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a760abb330b3341fc57fdbce270c2e88
https://opus.bibliothek.uni-wuerzburg.de/files/15024/132_Pritchard_Pain.pdf

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