Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Rory P. Remmel"'
Autor:
Xintian Lyu, BS, Sílvia M. Illamola, PharmD, PhD, Susan E. Marino, PhD, Ilo E. Leppik, MD, Stephen Dahmer, MD, Paloma Lehfeldt, MD, Jeannine M. Conway, PharmD, Rory P. Remmel, PhD, Kyle Kingsley, MD, Angela K. Birnbaum, PhD
Publikováno v:
Current Therapeutic Research, Vol 99, Iss , Pp 100709- (2023)
ABSTRACT: Background: Little is known about the distribution of cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) to patients participating in state medical cannabis programs. The Minnesota cannabis program requires third-party testing of products
Externí odkaz:
https://doaj.org/article/873d141727544d1ab98f223bb893dc11
Publikováno v:
Cell Transplantation, Vol 10 (2001)
Cytochrome P450 (CYP450) enzymes are essential for xenobiotic metabolism. Although CYP450s are found in many tissues, CYP2B1/2 are primarily expressed in the rat liver. The constitutive expression in vivo of CYP2B1/2 is low but it is induced in the p
Externí odkaz:
https://doaj.org/article/f1bdd0673a204fa695cd0be49785118c
Publikováno v:
Cell Transplantation, Vol 8 (1999)
Primary rat hepatocytes can self-assemble to form multicellular spheroids when plated onto Primaria petri dishes. Spheroids have been observed to exhibit enhanced liver-specific functions and differentiated ultrastructure compared to monolayer cultur
Externí odkaz:
https://doaj.org/article/5bd98762d82e43459274a7ea54e808e0
Autor:
Scott L. Nyberg, Ken Shirabe, Madhusudan V. Peshwa, Timothy D. Sielaff, Paul L. Crotty, Henry J. Mann, Rory P. Remmel, William D. Payne, Wei-Shou Hu, Frank B. Cerra M.D.
Publikováno v:
Cell Transplantation, Vol 2 (1993)
Metabolic activity of a gel-entrapment, hollow fiber, bioartificial liver was evaluated in vitro and during extracorporeal hemoperfusion in an anhepatic rabbit model. The bioartificial liver contained either 100 million rat hepatocytes (n = 12), fibr
Externí odkaz:
https://doaj.org/article/7cdc166c29d44087bc7f448ab05577a3
Autor:
Kevin A. Reininger, Guillaume Onyeaghala, Teresa Anderson‐Haag, David S. Schladt, Baolin Wu, Weihua Guan, Casey R. Dorr, Rory P. Remmel, Roslyn Mannon, Arthur J. Matas, William S. Oetting, Paul Stahler, Ajay K. Israni, Pamala A. Jacobson
Publikováno v:
Clinical transplantation.
Kidney transplant recipients carrying the CYP3A5*1 allele have lower tacrolimus troughs, and higher dose requirements compared to those with the CYP3A5*3/*3 genotype. However, data on the effect of CYP3A5 alleles on post-transplant tacrolimus managem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a84d5e55d2573b1fef047a101187e30
https://pubmed.ncbi.nlm.nih.gov/36571802
https://pubmed.ncbi.nlm.nih.gov/36571802
Autor:
Gen Investigators, Ajay K. Israni, Arthur J. Matas, Baolin Wu, David P. Schladt, Casey R. Dorr, Rory P. Remmel, DeKAF Genomics, Pamala A. Jacobson, David Ikle, William S. Oetting, Roslyn B. Mannon, Weihua Guan
Publikováno v:
Transplantation. 103:1591-1602
Background Identifying kidney allograft recipients who are predisposed to acute rejection (AR) could allow for optimization of clinical treatment to avoid rejection and prolong graft survival. It has been hypothesized that a part of this predispositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190df654f293c62c59781b970c020fc8
https://doi.org/10.1097/tp.0000000000002659
https://doi.org/10.1097/tp.0000000000002659
Autor:
Angela K. Birnbaum, Michaela J. Roslawski, Rory P. Remmel, Susan E. Marino, Ashwin Karanam, Ilo E. Leppik
Publikováno v:
Therapeutic Drug Monitoring. 41:357-370
A sensitive, robust method was developed and validated to quantitate 13 major natural cannabinoid parent and metabolite compounds in human plasma at or below 0.5 ng/mL.A liquid chromatography tandem mass spectrometry method was developed and validate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc39dc791a3dfb323fc495984b0a33f0
https://doi.org/10.1097/ftd.0000000000000583
https://doi.org/10.1097/ftd.0000000000000583
Autor:
David P. Schladt, Pamala A. Jacobson, Roslyn B. Mannon, Weihua Guan, Casey R. Dorr, Baolin Wu, Ajay K. Israni, William S. Oetting, Rory P. Remmel, Arthur J. Matas, Mahmoud Al-Kofahi
Publikováno v:
Journal of clinical pharmacologyReferences. 61(8)
Genetic variation in the CYP3A4 and CYP3A5 (CYP3A4/5) genes, which encode the key enzymes in tacrolimus metabolism, is associated with tacrolimus clearance and dose requirements. Tacrolimus has a narrow therapeutic index with high intra- and intersub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24916aa0012c918f7d71e2e4892b3ee
https://pubmed.ncbi.nlm.nih.gov/33512723
https://pubmed.ncbi.nlm.nih.gov/33512723
Autor:
Pamala A. Jacobson, Brendan J. Keating, Debra J. Skaar, Ajay K. Israni, Arthur J. Matas, Moataz E Mohamed, Danielle Berglund, Roslyn B. Mannon, Weihua Guan, Jessica van Setten, Rory P. Remmel, David P. Schladt, Rachael A. Pearson, Baolin Wu, Tam T Nguyen, William S. Oetting, Casey R. Dorr, Zachary Rivers
Publikováno v:
J Clin Pharm Ther
What is known and objective Pharmacogenomic biomarkers are now used in many clinical care settings and represent one of the successes of precision medicine. Genetic variants are associated with pharmacokinetic and pharmacodynamic changes leading to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c96010ff4edd7d55dacffdeeee4351f
https://europepmc.org/articles/PMC7719579/
https://europepmc.org/articles/PMC7719579/
Autor:
Russ B. Altman, Julia M. Barbarino, Taraswi Mitra-Ghosh, Samuel P. Callisto, Jatinder K. Lamba, Teri E. Klein, Rory P. Remmel, Angela K. Birnbaum
Publikováno v:
Pharmacogenet Genomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7248ddbafec97b191232eefd30d85801
https://pubmed.ncbi.nlm.nih.gov/32187155
https://pubmed.ncbi.nlm.nih.gov/32187155