Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rory L. Williams"'
Autor:
Rory L. Williams, Richard M. Murray
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Improving evolution stability of engineered functions is important for bioproduction and synthetic biology. Here, the authors developed an integrase-recombination-based terminal differentiation gene circuit in E. coli to improve the evolutionary stab
Externí odkaz:
https://doaj.org/article/cb8e54c1df76429c9e8de38135752e16
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebcfc7720d1848ea19440c3e7a8f431f
https://doi.org/10.1158/0008-5472.c.6511413.v1
https://doi.org/10.1158/0008-5472.c.6511413.v1
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Figure S4. Shows ARHGAP36 expression in mouse and human neural tissue. Figure S5. Shows characterization of ARHGAP36 and Megf10 in C17.2 cells Figures S6-S7 show mechanistic analysis of FOXR2 in C17.2 and HSC1L cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c88fb8090e9d0f93c8d64bec0f20df6
https://doi.org/10.1158/0008-5472.22423053
https://doi.org/10.1158/0008-5472.22423053
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Characterization of SB-induced medulloblastomas and CNS-PNETs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcf71417a72492031f7dbb0484851a0
https://doi.org/10.1158/0008-5472.22423056.v1
https://doi.org/10.1158/0008-5472.22423056.v1
Autor:
Michelle M. Frees, George Maxwell Otto, Sandra Wagner, David J. Odde, David A. Largaespada, Paramita Das, Pauline J. Beckmann, Rory L. Williams, Barbara R. Tschida, Robert B. Jenkins, Alex T. Larsson, Stephen C Schmechel, Quincy Rosemarie, Jon D. Larson, Charles G. Eberhart, Fausto J. Rodriguez, Eric P. Rahrmann, Xiaochong Wu, Jason Ostergaard, Jun Wang, Addison M. Demer, Michael D. Taylor, Daniel Picard, Adrian M. Dubuc, Ryan D Krebs, Catherine Lee, Annie Huang, Aaron L. Sarver, Robert J. Wechsler-Reya, Branden S. Moriarity, Anthony E. Rizzardi, Amy M. Molan, Ghaidan Shamsan
Publikováno v:
Cancer Research. 79:905-917
Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40f8f826ae2377aa0bdaea941a7d85f
https://doi.org/10.1158/0008-5472.can-18-1261
https://doi.org/10.1158/0008-5472.can-18-1261
Autor:
Christopher S. Henry, Rory L. Williams, Said R. Bogatyrev, Tahmineh Khazaei, Rustem F. Ismagilov, John Doyle
Changes in the composition of the human microbiome are associated with health and disease. Some microbiome states persist in seemingly unfavorable conditions, e.g., the proliferation of aerobe-anaerobe communities in oxygen-exposed environments in wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb0c2617c417166da26fc986954b60f
Autor:
Andrew Morin, Kyle A. Williams, Shadi Zahedi, Eliza Baird-Daniel, Jean Mulcahy-Levy, Rajeev Vibhakar, Nicholas K. Foreman, Rory L. Williams, Michelle Desmarais
Publikováno v:
Neuro-Oncology
Background Autophagy inhibition is a potential treatment for central nervous system (CNS) tumors. Autophagy, a heavily regulated process by which cellular waste is transferred to lysosomes for degradation and processing, is an integral part of tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f613959826a2b37aa07e145867ebed8e
https://doi.org/10.1093/neuonc/noab090.179
https://doi.org/10.1093/neuonc/noab090.179
Autor:
Said R. Bogatyrev, Tahmineh Khazaei, John Doyle, Rustem F. Ismagilov, Rory L. Williams, Christopher S. Henry
Publikováno v:
Science Advances
Multistability and hysteresis is a potential mechanism to describe shifts to and persistence of aerobe-anaerobe communities.
Major changes in the microbiome are associated with health and disease. Some microbiome states persist despite seemingly
Major changes in the microbiome are associated with health and disease. Some microbiome states persist despite seemingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f80f768bc46aa3a135dc37e7f845b94
https://pubmed.ncbi.nlm.nih.gov/32851161
https://pubmed.ncbi.nlm.nih.gov/32851161
Autor:
Katherine E. Chaney, Rory L. Williams, Mohammad Azam, David A. Largaespada, Kwangmin Choi, Annmarie Ramkissoon, David Milewski, Sara Szabo, Nancy Ratner, Tanya V. Kalin, Joseph G. Pressey, Adam Miller, Kyle B. Williams
Publikováno v:
Clin Cancer Res
Purpose: In neurofibromatosis type 1 (NF1) and in highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), constitutively active RAS-GTP and increased MAPK signaling are important in tumorigenesis. Dual specificity phosphatases (DUSPs) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247f1f25ef16a41a6e1d69822b7d7a5c
https://europepmc.org/articles/PMC6606396/
https://europepmc.org/articles/PMC6606396/
Publikováno v:
Molecular Cancer Therapeutics. 16:A37-A37
Neurofibromatosis Type 1 (NF1) is a common (1:2500 births) genetic disorder and cancer predisposition syndrome, caused by mutations in the tumor suppressor gene NF1. One of the known functions of the protein encoded by NF1 (neurofibromin) is that of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f245d1927498d589fcd65dca95980eb5
https://doi.org/10.1158/1538-8514.synthleth-a37
https://doi.org/10.1158/1538-8514.synthleth-a37