Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rory J. Flinn"'
Publikováno v:
Nature Protocols. 9:182-192
Macropinocytosis serves as an internalization pathway for extracellular fluid and its contents. Macropinocytosis is upregulated in oncogene-expressing cells and, recently, we have revealed a functional role for macropinocytosis in fueling cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e4ee3b51c5f349ff35765d91410d6a
https://doi.org/10.1038/nprot.2014.004
https://doi.org/10.1038/nprot.2014.004
Autor:
Rory J. Flinn, Maria Pozzuto, Zhen Ni Zhou, Pamela Boimel, Tatiana Smirnova, John S. Condeelis, Jonathan M. Backer, Nancy E. Hynes, Jeffrey Wyckoff, Anne R. Bresnick, Jeffrey E. Segall, Salvatore J. Coniglio
Publikováno v:
Oncogene
Many malignancies show increased expression of the epidermal growth factor (EGF) receptor family member ErbB3 (HER3). ErbB3 binds heregulin β-1 (HRGβ1) and forms a heterodimer with other ErbB family members, such as ErbB2 (HER2) or EGF receptor (EG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db867f1ab3b37943f77f1a769903fa7
https://doi.org/10.1038/onc.2011.275
https://doi.org/10.1038/onc.2011.275
Autor:
Bijay S. Jaiswal, Jonathan M. Backer, Vasantharajan Janakiraman, Somasekar Seshagiri, Haiyan Wu, Mirvat El-Sibai, Gary J. Gerfen, K. Ilker Sen, Rory J. Flinn, S. Chandra Shekar, Mark E. Girvin
We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires ( i ) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and ( ii ) a contact between the p85 nSH2 and iSH2 domains th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb3442ab739de6f9af985344ade70ef
https://europepmc.org/articles/PMC2787125/
https://europepmc.org/articles/PMC2787125/
Publikováno v:
Biochemical Journal
The mammalian Class III PI3K (phosphoinositide 3-kinase), hVps34 [mammalian Vps (vacuolar protein sorting) 34 homologue], is an important regulator of vesicular trafficking, autophagy and nutrient sensing. In yeast, Vps34 is associated with a putativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7b2a29457b5fac2e0227c2f65b9f56
https://pubmed.ncbi.nlm.nih.gov/18957027
https://pubmed.ncbi.nlm.nih.gov/18957027
Autor:
Rory J. Flinn, Huan Pang, Jonathan M. Backer, John S. Condeelis, Peri Nalbant, Michael Cammer, Mirvat El-Sibai, Frank P. Macaluso, Klaus M. Hahn, Corina Sarmiento
Cdc42 plays a central role in regulating the actin cytoskeleton and maintaining cell polarity. Here, we show that Cdc42 is crucial for epidermal growth factor (EGF)-stimulated protrusion in MTLn3 carcinoma cells. When stimulated with EGF, carcinoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed4b52908f758b9e12d91ef94181dac
Autor:
Rory J. Flinn, Jonathan M. Backer
Publikováno v:
Cell Cycle. 9:1869-1870
The multi-component mTORC1 complex integrates growth factor and nutrient signals to positively regulate protein synthesis and cell growth through its two major substrates, S6K1 and 4EBP1.1,2 Growth factors, such as insulin, activate mTORC1 through a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38a4523622f6496c78f29b20a07c4c7
https://doi.org/10.4161/cc.9.10.11679
https://doi.org/10.4161/cc.9.10.11679
Publikováno v:
Biochemical Journal; 2009, Vol. 417 Issue 3, p747-755, 9p