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pro vyhledávání: '"Rory A. Hills"'
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
Autor:
Kuan-Ying A. Huang, Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Susan K. Vester, Rory A. Hills, Mark Howarth, Jennifer R. Keeffe, Alexander A. Cohen, Leesa M. Kakutani, Yi-Min Wu, Md Shahed-Al-Mahmud, Yu-Chi Chou, Pamela J. Bjorkman, Alain R. Townsend, Che Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
An antibody, IY-2A, identified from a panel of class-4 SARS-CoV-2-neutralizing antibodies isolated from convalescent and vaccinated individuals, targets and induces partial unfolding of a conserved epitope within the RBD. IY-2A retains activity again
Externí odkaz:
https://doaj.org/article/4fd4ed3b1b214dcab49cfc9d3f96eda6
Autor:
Susan K. Vester, Rolle Rahikainen, Irsyad N. A. Khairil Anuar, Rory A. Hills, Tiong Kit Tan, Mark Howarth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The SpyCatcher-SpyTag system allows protein anchoring and nanoassembly. Here, the authors engineer SpySwitch, a dually switchable Catcher which allows gentle purification of SpyTagged proteins prior to downstream applications such as the assembly of
Externí odkaz:
https://doaj.org/article/bdaf544209824dad9f2d175eff328eec
Autor:
Rory A. Hills, Tiong Kit Tan, Alexander A. Cohen, Jennifer R. Keeffe, Anthony H. Keeble, Priyanthi N.P. Gnanapragasam, Kaya N. Storm, Michelle L. Hill, Sai Liu, Javier Gilbert-Jaramillo, Madeeha Afzal, Amy Napier, William S. James, Pamela J. Bjorkman, Alain R. Townsend, Mark Howarth
Defending against future pandemics may require vaccine platforms that protect across a range of related pathogens. The presentation of multiple receptor-binding domains (RBDs) from evolutionarily-related viruses on a nanoparticle scaffold elicits a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e857811f0ce869e16ac1c9c48ca3bee6
https://doi.org/10.1101/2023.02.24.529520
https://doi.org/10.1101/2023.02.24.529520
Autor:
Mark Howarth, Rory A Hills
Publikováno v:
Current Opinion in Biotechnology
Graphical abstract
Virus-like particles (VLPs) can play important roles in prevention and therapy for infectious diseases and cancer. Here we describe recent advances in rational construction of VLP assemblies, as well as new approaches to enhan
Virus-like particles (VLPs) can play important roles in prevention and therapy for infectious diseases and cancer. Here we describe recent advances in rational construction of VLP assemblies, as well as new approaches to enhan